scholarly journals Primary activity standardization of 177Lu for calibrating commercial dose calibrator

2020 ◽  
Vol 1505 ◽  
pp. 012023
Author(s):  
Agung Agusbudiman ◽  
Nur Rahmah Hidayati ◽  
Martalena Ramli ◽  
Holnisar
2009 ◽  
Vol 67 (10) ◽  
pp. 1887-1891 ◽  
Author(s):  
A. Iwahara ◽  
R. Poledna ◽  
C.J. da Silva ◽  
L. Tauhata

2014 ◽  
Vol 87 ◽  
pp. 175-178 ◽  
Author(s):  
Paulo A.L. da Cruz ◽  
Carlos J. da Silva ◽  
Denise S. Moreira ◽  
Akira Iwahara ◽  
Luiz Tauhata ◽  
...  

2017 ◽  
Vol 314 (2) ◽  
pp. 545-553 ◽  
Author(s):  
Karsten Kossert ◽  
Justyna Marganiec-Gałązka ◽  
Ole J. Nähle

2020 ◽  
Vol 27 (5) ◽  
pp. 400-410
Author(s):  
Valentina De Luca ◽  
Luigi Mandrich

: Enzymes are among the most studied biological molecules because better understanding enzymes structure and activity will shed more light on their biological processes and regulation; from a biotechnological point of view there are many examples of enzymes used with the aim to obtain new products and/or to make industrial processes less invasive towards the environment. Enzymes are known for their high specificity in the recognition of a substrate but considering the particular features of an increasing number of enzymes this is not completely true, in fact, many enzymes are active on different substrates: this ability is called enzyme promiscuity. Usually, promiscuous activities have significantly lower kinetic parameters than to that of primary activity, but they have a crucial role in gene evolution. It is accepted that gene duplication followed by sequence divergence is considered a key evolutionary mechanism to generate new enzyme functions. In this way, promiscuous activities are the starting point to increase a secondary activity in the main activity and then get a new enzyme. The primary activity can be lost or reduced to a promiscuous activity. In this review we describe the differences between substrate and enzyme promiscuity, and its rule in gene evolution. From a practical point of view the knowledge of promiscuity can facilitate the in vitro progress of proteins engineering, both for biomedical and industrial applications. In particular, we report cases regarding esterases, phosphotriesterases and cytochrome P450.


Religions ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 533
Author(s):  
Daniel Porubec

P. A. Florensky dedicated nine writings of his rich interdisciplinary work to the phenomenon of cult, which were first published in a censored form in 1977. We turn our attention to one of these writings called Cult, Religion and Culture, published under the common title Philosophy of Cult, in which the author elaborates a distinctive concept of the cult as the primary activity of man and at the same time as the gift offered to him for his own sanctification. It is the sacred cult—sacra from where, according to the author, two other human activities originate: namely, the ability to create tools—instrumenta—and the ability to create abstract concepts—notiones. However, both human activities have to be understood as a process of disintegration of the cult—sacra. Thus, by prioritizing one of the three human activities mentioned above, we can recognize three historical periods in history. According to Florensky, the human ability to create tools corresponds to the era of historical materialism, the ability to create concepts corresponds to the era of ideologism, and ultimately, the primary human activity—the life of man in the cult and its culture corresponds to the sacral materialism or concrete idealism.


Author(s):  
Jiajia Mou ◽  
Shuang Qiu ◽  
Danghui Chen ◽  
Yanru Deng ◽  
Teka Tekleab

2021 ◽  
pp. 152660282199671
Author(s):  
Robert Drescher ◽  
Philipp Seifert ◽  
Falk Gühne ◽  
René Aschenbach ◽  
Christian Kühnel ◽  
...  

Purpose: To evaluate the microsphere outflow dynamics and residual Ho-166 activity during and after transarterial radioembolization planning and treatment procedures, and to assess the distribution and predilection sites of residual activity in the proprietary delivery set and the microcatheter. Materials and Methods: Fifteen planning and 12 therapeutic radioembolization procedures were performed with poly-l-lactic acid microspheres loaded with Ho-166. The amount and distribution of residual activity was assessed by dose calibrator measurements and SPECT imaging. The activity flow profile from the microcatheter was assessed dynamically. For planning procedures, different injection methods were evaluated in order to attempt to decrease the residual activity. Results: The median residual activities for planning and treatment procedures using standard injection methods were 31.2% (range 17.3%–44.1%) and 4.3% (range 3.5%–6.9%), respectively. Planning residual activities could be decreased significantly with 2 injection methods similar to treatment procedures, to 17.5% and 10.9%, respectively ( P = 0.002). Main predilection sites of residual microspheres were the 3-way stopcock and the outflow needle connector. During treatment procedures, more than 80% of the injected activity is transferred during the first 3 injection cycles. Conclusion: After treatment procedures with holmium-loaded microspheres, mean residual activity in the delivery set is reproducibly low and between reported values for glass and resin microspheres. The majority of microspheres is transferred to the patient during the second and third injection cycle. An estimated residual waste of 3% to 4% may be included in the treatment activity calculation. For planning procedures, a modified injection technique should be used to avoid high residual activities.


2004 ◽  
Vol 16 (1) ◽  
Author(s):  
Retno Woro Kaeksi ◽  
Umrotun Umrotun ◽  
Susanto Susanto ◽  
Triana Nur Handayani ◽  
Satriyo Nugroho

The research is carried out in Surakarta. The goal of the study is to know: the characteristic of the homeless, the factors that cause them to he the homeless and the strategis of the homeless to survive in Surakarta. The research uses survey method, while its area is chosen purposively. The research also uses primary and secondary data. The primary data is obtained by interviewing the respondents with questionnaire, while secondary data is based on the information got from the relevant institution.The resjoondents are taken 10 % randomly from all the population. The results of the rsearch show that the homeless are 11-8 years old (96.66%), most of them are boys (91.11%). The majority of the respondents did graduate from the Lower Secondary School (55.56%); most of them come from outside of Surakarta (62%). Their primary activity is as singing beggars (62,22 %) and their daily income is about RP 10. 000 RP 14. 000 (60.00%). Their parents are uneducated people. They are only graduated from Elementary School (7S.56%).The factors that cause them to he homeless are the economic factor 77.78%, lack of family attention (13.33%) and the willingness to he independent (80.89%). Based on the  result this research, we know that the poverty has made the children become homeless. The strategis to survive are: they are thrif (40%), add their time to work (13.13%), move to other place (11.11%) and save their money (15.56%).


2019 ◽  
Vol 1 (40) ◽  
Author(s):  
Njegoslav Jović

In this paper, the author analyzes the benefits and limitationsof international arbitration in disputes that are subject to intellectual propertyrights. Intellectual property law disputes have special characteristics. In theevent of a dispute with an international element, there is a problem with thejurisdiction of state courts due to the principle of the territoriality of intellectualproperty rights. The titular of the right must initiate court proceedings in allcountries individually, leading to delays in procedures, multiplication of costsand uneven judicial practice. For these reasons, the author analyzes alternativedispute resolution through arbitration to determine whether this method ofdispute resolution is more acceptable to foreign courts.The author particularly pays attention to the WIPO Center for Arbitrationand Mediation as a permanent arbitration institution whose primary activity isthe resolution of disputes in the field of intellectual property rights.


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