Synthesis of steroid bearing heterocyclic derivatives and biological activity. Review 2014-2020

This research includes synthesis of new seventh-membered heterocyclic derivatives as 1,3-oxazepine-dione derived from azomethine compounds. Azomethine compounds R1-R4 were synthesized by the reaction of aromatic aldehydes with primary aromatic amines. The novel of 1,3-oxazepine-dione derivatives R5-R9 were obtained from the treatment of azomethine compounds with anhydrides. The synthesized compounds were checked by TLC technique, spectral methods (FT-IR, H1-NMR) and measurements of some its physical properties. The biological activity of the heterocyclic derivatives was investigated against bacteria and fungi in vitro.

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Synthesis, Identification and Studying Biological Activity of Some Heterocyclic Derivatives from 3, 5-Dinitrosalicylic Acid

Journal of Physics Conference Series ◽

10.1088/1742-6596/1234/1/012091 ◽

2019 ◽

Vol 1234 ◽

pp. 012091 ◽

Cited By ~ 2

Author(s):

R Kais ◽

S Adnan

Keyword(s):

Biological Activity ◽

Heterocyclic Derivatives

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Synthesis and Characterization of Some New Heterocyclic Derivatives and Studying of their Biological Activity (Anti-Bacteria)

International Journal of Pharmaceutical Quality Assurance ◽

10.25258/ijpqa.11.1.6 ◽

2020 ◽

Vol 11 (01) ◽

pp. 38-44

Author(s):

Shaimaa A. Behjet ◽

Zahraa F. Khudair

Keyword(s):

Biological Activity ◽

Schiff Base ◽

Thioglycolic Acid ◽

Diazonium Salt ◽

Synthesis And Characterization ◽

Second Step ◽

Aminobenzoic Acid ◽

Schiff Base Derivatives ◽

Heterocyclic Derivatives

Introduction: In this work synthesis, many kinds of heterocyclic derivatives by many steps, the first we preparation 1-(4-((1H-imidazol_2-yl-) diazenyl) phenyl) ethan-1_one. (1) by coupling of diazonium salt of p-amino acetophenone with imidazole in alkaline alcoholic media, the second step include react (1) with 2_amino_6_methylpyrimidin _4_ol in acid medium to get Schiff base derivatives(2)the last step include react(2) with (sodium azide, thioglycolic acid, glycine, alanine, Tryptophan, (2 aminobenzoic acid), (2-mercaptobenzoic acid) to give (tetrazole(3), thiazolidine(4), imidazolidine(5-7), Thiazinie(8), Quinazoline (9) derivatives, respectively. All these derivatives Characterization by FTIR, 1HNMR, 13C-NMR, After that we studied the biological activity for all derivatives for all derivatives studied the anticancer for (2).

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Synthesis of New Heterocyclic Compounds Derived from Anthrone and Evaluation of Their Biological Activity

Baghdad Science Journal ◽

10.21123/bsj.5.4.627-637 ◽

2008 ◽

Vol 5 (4) ◽

pp. 627-637

Author(s):

Baghdad Science Journal

Keyword(s):

Escherichia Coli ◽

Staphylococcus Aureus ◽

Biological Activity ◽

Heterocyclic Compounds ◽

Heterocyclic Amines ◽

Pathogenic Microorganism ◽

Standard Strain ◽

Chemical Structures ◽

Heterocyclic Derivatives

In this research, Schiff bases derived from the reaction of anthrone with different heterocyclic amines have been described. The resulted Schiff base compounds were reacted with various nucleophiles in order to obtain new heterocyclic derivatives. Chemical structures of all products were confirmed by IR, 1H-, 13C-NMR spectral data and elemental analysis. All synthesized compounds were in vitro tested against a standard strain of pathogenic microorganism including Gram +ve bacteria (Staphylococcus aureus), Gram –ve bacteria (Escherichia coli), and fungi (Candida albicans).

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