scholarly journals Effect of Adding Titania and Alumina on the Bioactivity Properties of Porous Hydroxyapatite via Replication Method for Bone Reconstruction

2021 ◽  
Vol 1963 (1) ◽  
pp. 012032
Author(s):  
Sara H. Shahatha ◽  
Mudhafar A. Mohammed ◽  
Safa H. Mohammed ◽  
Lina Mohammed Jaffer
Keyword(s):  
Bone Reconstruction ◽  
Porous Hydroxyapatite ◽  
Replication Method

scholarly journals PENGARUH VARIASI WAKTU TAHAN SINTERING TERHADAP HIDROKSIAPATIT BERPORI DARI TULANG IKAN TENGGIRI (Scomberomorus guttatus)

2020 ◽  
Vol 5 (1) ◽  
pp. 54
Author(s):  
Lia Anggresani ◽  
Rizka Afrina ◽  
Armini Hadriyati ◽  
Rahmadevi Rahmadevi ◽  
Mukhlis Sanuddin
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Deposition Time ◽  
Holding Time ◽  
Bone Reconstruction ◽  
Porous Hydroxyapatite ◽  
Hardness Tester ◽  
Fish Bones ◽  
Calcium And Phosphorus

<p><em>Tulang ikan tenggiri memiliki kandungan  kalsium dan fosfor. Sehingga tulang ikan dapat dibuat biomaterial hydroxyapatite berpori, Hydroxyapatite berpori  cocok untuk merekontruksi tulang.  pori yang terbentuk berfungsi sebagai media pembentukan jaringan sel tulang yang tumbuh untuk meningkatkan regenerasi tulang. Penelitian ini bertujuan melihat pengaruh variasi waktu tahan sintering dari hydroxyapatite berpori pada tulang ikan tenggiri. Bubuk CaO dibuat dari tulang ikan yang di rendam menggunakan NaOH dan aseton lalu difurnace 800°C. Bubuk CaO ditambahkan H</em><em><sub>3</sub>PO<sub>4.</sub> Atur pH hingga 10 dengan menambahkan NaOH lalu difurnace  900<sup>o</sup>C dengan lama pengendapan 12 dan 24 jam lalu dianalisa XRD. Hydroxyapatite yang didapatkan ditambahkan Polimer kitosan. selanjutnya dianalisa dengan SEM,PSA dan Hardness tester. Hasil Analisa XRF didapatkan CaO  50,814%. Hasil XRD pada pengendapan 12jam terbentuk senyawa hydroxyapatite dan trikalsium bis(phosphate(V)Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>), sedangkan pengendapan 24jam terbentuk senyawa hydroxyapatite (Ca<sub>5</sub>(PO<sub>4</sub>)<sub>3</sub>(OH) murni. Analisa SEM dilakukan pada variasi waktu sintering 4,5 dan 6 jam didapatkan morfologi yang tidak seragam. Hasil PSA pada waktu 4jam 0,873μm, 5jam 0,808μm dan 6jam 1,123μm. Uji Hardness Tester pada waktu 4jam 50 N, 5jam 54,1 N dan 6 jam 32,6 N. Dapat disimpulkan bahwa variasi waktu tahan sintering mempengaruhi sifat mekanik dan pada variasi lama pengendapan akan mempengaruhi pembentukan senyawa hydroksiapatite.</em></p><p><em><br /></em></p><p><em>Mackerel fish bones contain calcium and phosphorus. So that fish bones can be made porous hydroxyapatite biomaterial, porous Hydroxyapatite is suitable for bone reconstruction. The pore formed functions as a medium for the formation of bone tissue that grows to increase bone regeneration. This study aims to look at the effect of variations in the sintering resistant time of porous hydroxyapatite on mackerel fish bones. CaO powder is made from fish bones soaked using NaOH and acetone and then mixed with 800 ° C. CaO powder added H<sub>3</sub>PO<sub>4</sub>. Set the pH to 10 by adding NaOH then 900<sup>o</sup>C refined with a deposition time of 12 and 24 hours and then analyzed by XRD. Hydroxyapatite obtained was added with chitosan polymer. then analyzed with SEM, PSA and Hardness tester. XRF analysis results obtained CaO 50,814%. XRD results on 12 hours deposition of pure hydroxyapatite and tricalcium bis (phosphate (V)Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>) compounds, while 24 hours deposition of pure hydroxyapatite (Ca<sub>5</sub>(PO4)<sub>3</sub>(OH) compounds were formed. and 6 hours obtained non-uniform morphology, PSA results at 4 hours 0.873μm, 5 hours 0.808μm and 6 hours 1.123μm Hardness Tester test at 4 hours 50 N, 5 hours 54.1 N and 6 hours 32.6 N. It can be concluded that variation of sintering holding time affects the mechanical properties and the variation of the depositional time will affect the formation of hydroxyapatite compounds.</em></p><p><em><br /></em></p>

scholarly journals An Experimental Study of Porous Hydroxyapatite Scaffold Bioactivity in Biomedical Applications

2021 ◽  
Vol 39 (6) ◽  
pp. 977-985
Author(s):  
Auday A. Mehatlaf ◽  
Alaa A. Atiyah ◽  
Saad B. H. Farid
Keyword(s):  
Xrd Analysis ◽  
Porous Scaffolds ◽  
Dense Layer ◽  
X Ray Diffraction ◽  
Bioactive Materials ◽  
Porous Hydroxyapatite ◽  
Replication Method ◽  
Materials Used ◽  
Hydroxyapatite Scaffold ◽  
Interconnected Pores

Hydroxyapatite is one of the most bioactive materials used in tissue engineering due to its excellent biocompatibility and chemical composition which is equivalent to the mineral element of bone. In this study, polymer sponge replication method was used to fabricate porous hydroxyapatite scaffolds. Pure phase of hydroxyapatite scaffolds and the chemical bonding were verified via Fourier Transform Infrared and X-ray diffraction. Emission scanning electron microscopy (F E S E M) examination showed that the proposed scaffold has high interconnected pores that were achieved just after sintering at temperatures 1350 ºC for 2 hours. The percentage porosity values were estimated to be between 75–78 percent. The bioactivity of porous scaffolds was also investigated. They were submerged in a slurry of simulated body fluid (S B F) for seven, fourteen, and twenty-one days, respectively. Both FESEM and XRD analysis have confirmed the bioactivity of the prepared porous hydroxyapatite scaffold through the formation of a dense layer of apatite on its surface. Based on the results, the porous hydroxyapatite scaffolds could be recommended as a critical option for bone defects as well as replacement applications.

scholarly journals Synthesis of porous hydroxyapatite scaffolds from waste cockle shells by polyurethane sponge replication method

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Fitri Afriani ◽  
Anisa Indriawati ◽  
Widodo Budi Kurniawan ◽  
Yekti Widyaningrum ◽  
Rifqi Almusawi Rafsanjani ◽  
...  
Keyword(s):  
Porous Hydroxyapatite ◽  
Replication Method ◽  
Polyurethane Sponge

Replication of Wet Objects and Cells

1974 ◽  
Vol 32 ◽  
pp. 102-103
Author(s):  
S. Basu ◽  
D. F. Parsons
Keyword(s):  
Water Vapor Pressure ◽  
High Vacuum ◽  
Polystyrene Latex ◽  
Vacuum System ◽  
Saturated Water Vapor ◽  
Replication Method ◽  
New Methods ◽  
Saturated Water ◽  
Water Vapors ◽  
Intermediate Chamber

We are approaching the invasiveness of cancer cells from the studies of their wet surface morphology which should distinguish them from their normal counterparts. In this report attempts have been made to provide physical basis and background work to a wet replication method with a differentially pumped hydration chamber (Fig. 1) (1,2), to apply this knowledge for obtaining replica of some specimens of known features (e.g. polystyrene latex) and finally to realize more specific problems and to improvize new methods and instrumentation for their rectification. In principle, the evaporant molecules penetrate through a pair of apertures (250, 350μ), through water vapors and is, then, deposited on the specimen. An intermediate chamber between the apertures is pumped independently of the high vacuum system. The size of the apertures is sufficiently small so that full saturated water vapor pressure is maintained near the specimen.

New Model of Bone Reconstruction Specially Designed for Skull Base Surgery—Long-Term Testing in Primates

Skull Base ◽  
2007 ◽  
Vol 17 (S 1) ◽  
Author(s):  
Cleopatra Charalampaki ◽  
Axel Heimann ◽  
Laszlo Kopacs ◽  
Oliver Kempski
Keyword(s):  
Skull Base ◽  
Skull Base Surgery ◽  
Bone Reconstruction ◽  
New Model

scholarly journals Rapid conversion of highly porous borate glass microspheres into hydroxyapatite

2021 ◽  
Author(s):  
Md Towhidul Islam ◽  
Laura Macri-Pellizzeri ◽  
Virginie Sottile ◽  
Ifty Ahmed
Keyword(s):  
Borate Glass ◽  
Rapid Development ◽  
Glass Microspheres ◽  
Porous Hydroxyapatite ◽  
Interconnected Porosity ◽  
Highly Porous ◽  
Rapid Conversion

This paper reports on the rapid development of porous hydroxyapatite (HA) microspheres with large external pores and fully interconnected porosity.

scholarly journals Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Wendy E. Brown ◽  
Brian J. Huang ◽  
Jerry C. Hu ◽  
Kyriacos A. Athanasiou
Keyword(s):  
Mechanical Properties ◽  
Interfacial Shear Strength ◽  
Femoral Condyle ◽  
Interfacial Shear ◽  
Cartilage Defects ◽  
Porous Hydroxyapatite ◽  
Cartilage Lesions ◽  
Large Cartilage Lesions ◽  
Articular Cartilage Defects ◽  
Shape And Size

AbstractDespite the prevalence of large (>5 cm2) articular cartilage defects involving underlying bone, current tissue-engineered therapies only address small defects. Tissue-engineered, anatomically shaped, native-like implants may address the need for off-the-shelf, tissue-repairing therapies for large cartilage lesions. This study fabricated an osteochondral construct of translationally relevant geometry with robust functional properties. Scaffold-free, self-assembled neocartilage served as the chondral phase, and porous hydroxyapatite served as the osseous phase of the osteochondral constructs. Constructs in the shape and size of an ovine femoral condyle (31 × 14 mm) were assembled at day 4 (early) or day 10 (late) of neocartilage maturation. Early osteochondral assembly increased the interfacial interdigitation depth by 244%, interdigitation frequency by 438%, interfacial shear modulus by 243-fold, and ultimate interfacial shear strength by 4.9-fold, compared to late assembly. Toward the development of a bioprosthesis for the repair of cartilage lesions encompassing up to an entire condylar surface, this study generated a large, anatomically shaped osteochondral construct with robust interfacial mechanical properties and native-like neocartilage interdigitation.

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