Cerebral stroke is one of the most common causes of death; in most countries it is ranking the third position by the incidence rate. The prevalence of strokes in Ukraine is one of the highest in Europe. In recent years, there has been an increase in the prevalence of post-stroke cognitive and anxiety-depressive disorders. The aim of the study is to identify and analyze the features of correlations between cognitive and psycho-emotional disorders in people in the acute period of cerebral ischemic stroke of different hemispheric localization. Materials and methods. The study included 43 post-stroke patients, average age 59.81±1.28 years. The dextrocerebral ischemic stroke was diagnosed in 20 patients (46.5%, group 1; average age 61.25±1.98 years), sinistrocerebral ischemic stroke was detected in 23 patients (53.5%, group 2; average age 58.57±1.67 years). The control group consisted of 16 healthy individuals (10 men and 6 women, the average age 59.5±1.74 years). All patients underwent comprehensive neuropsychological testing. The examination was carried out on the 3rd - 7th days following the cerebrovascular event. Assessment of neurocognitive status was performed by using the Mini-Mental State Examination, the Montreal Cognitive Assessment Scoring, Beck’s Depression Scale, and the Spielberger-Khanin Reactive and Personal Anxiety Questionnaire. The analysis of the results obtained showed that the patients with sinistrocerebral ischemic stroke have a positive correlation between post-stroke cognitive impairment (total score Mini-Mental State Examination = 21.3±0.61, Montreal Cognitive Assessment Scoring = 18.22±0.9) and indicators of language, speech and memory dysfunctions as compared to the individuals with ischemic stroke in the right carotid pool, who have positive correlations between indicators of post-stroke cognitive impairment (total score Mini-Mental State Examination = 24.05±0.52, Montreal Cognitive Assessment Scoring = 21.35±0.84) and indicators of attention and abstract thinking dysfunction. Indicators of depressive disorders positively correlate with indicators of post-stroke cognitive dysfunction only in the group of sinistrocerebral ischemic stroke, while the degree and frequency of depressive disorders are significantly more often observed when ischemic focus is localized in the right hemisphere, and their indicators have direct correlations in both groups of patients. The features of correlations between psychodiagnostic indicators taking into account lateralization of the ischemic centre, investigated in the study, can serve as a ground for applying separate subtest-blocks of the specified psychodiagnostic scales for patients with hemispheric ischemic stroke. This approach is time-saving, and can make the scale more widely available and accelerate the screening of neurocognitive status in order to optimize therapeutic and rehabilitation interventions.