Receptor-mediated gene delivery using chemically modified chitosan

2007 ◽  
Vol 2 (3) ◽  
pp. S95-S100 ◽  
Author(s):  
T H Kim ◽  
H L Jiang ◽  
J W Nah ◽  
M H Cho ◽  
T Akaike ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Modified Chitosan ◽  
Chemically Modified

scholarly journals Selective Modification of Chitosan to Enable the Formation of Chitosan-DNA Condensates by Electron Donator Stabilization

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Karl E. Kador ◽  
Anuradha Subramanian
Keyword(s):  
Drug Delivery ◽  
Gene Delivery ◽  
Transfection Efficiency ◽  
Protonated Form ◽  
Chemical Modifications ◽  
Modified Chitosan

Chitosan, a polyaminosaccharide, has been investigated for its use in the field of drug-delivery and biomaterial applications because of its natural biocompatibility and polycationic properties. Chemical modifications of chitosan have been attempted in an effort to increase the transfection efficiency with respect to gene delivery applications; however, it is unknown how these modifications affect the formation of the condensates. This study attempts to determine the effects of modification of the cationic center of chitosan on the ability to condense DNA. Specifically, electron-donating or -withdrawing groups were used as modifiers of the cationic charge on the chitosan backbone to stabilize the protonated form of chitosan, which is necessary to form condensates and increase the efficiency of the polymer to condense DNA by yielding condensates at a lower nitrogen to phosphorous (N : P) ratio. While an N : P ratio of 7 is needed to condense DNA with unmodified chitosan, phthalate-modified chitosan yielded condensates were obtained at an N : P ratio of 1.0.

Synthesis of chemically modified chitosan with 2,5-dimercapto-1,3,4-thiodiazole and its adsorption abilities for Au(III), Pd(II), and Pt(IV)

2009 ◽  
Vol 113 (3) ◽  
pp. 1604-1610 ◽  
Author(s):  
Fei Li ◽  
Changli Bao ◽  
Jianhui Zhang ◽  
Qi Sun ◽  
Weiwei Kong ◽  
...  
Keyword(s):  
Modified Chitosan ◽  
Chemically Modified

scholarly journals Application of Chemically Modified Chitosan for Removal of Arsenic from Water: A Column Bed Experiment

2019 ◽  
Vol 8 (06) ◽  
pp. 2893-2902
Author(s):  
Ashutosh Kumar Singh ◽  
S.P. Shukla ◽  
Saurav Kumar ◽  
Priyanka Sahu ◽  
Neeraj Kumar
Keyword(s):  
Modified Chitosan ◽  
Chemically Modified ◽  
Removal Of Arsenic

Spectroscopic, thermal characterizations and bacteria inhibition of chemically modified chitosan with phthalic anhydride

2020 ◽  
Vol 240 ◽  
pp. 122053 ◽  
Author(s):  
Elton Marks Araujo Braz ◽  
Solranny Carla Cavalcante Costa Silva ◽  
Carla Adriana Rodrigues Sousa Brito ◽  
Lucas Moreira Brito ◽  
Humberto Medeiros Barreto ◽  
...  
Keyword(s):  
Phthalic Anhydride ◽  
Modified Chitosan ◽  
Chemically Modified ◽  
Bacteria Inhibition
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