Exploring platelet lysate hydrogel-coated suture threads as biofunctional composite living fibers for cell delivery in tissue repair

Stem cell-based cardiac therapies have been extensively studied in recent years. However, the efficacy of cell delivery, engraftment, and differentiation post-transplant remain continuous challenges and represent opportunities to further refine our current strategies. Despite limited long-term cardiac retention, stem cell treatment leads to sustained cardiac benefit following myocardial infarction (MI). This review summarizes the current knowledge on stem cell based cardiac immunomodulation by highlighting the cellular and molecular mechanisms of different immune responses to mesenchymal stem cells (MSCs) and their secretory factors. This review also addresses the clinical evidence in the field.

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Engineering the matrix microenvironment for cell delivery and engraftment for tissue repair

Current Opinion in Biotechnology ◽

10.1016/j.copbio.2013.04.005 ◽

2013 ◽

Vol 24 (5) ◽

pp. 864-871 ◽

Cited By ~ 20

Author(s):

Amy Y Cheng ◽

Andrés J García

Keyword(s):

Tissue Repair ◽

Cell Delivery ◽

The Matrix

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In vivo assessment of grafted cortical neural progenitor cells and host response to functionalized self-assembling peptide hydrogels and the implications for tissue repair

Journal of Materials Chemistry B ◽

10.1039/c4tb01391c ◽

2014 ◽

Vol 2 (44) ◽

pp. 7771-7778 ◽

Cited By ~ 41

Author(s):

A. L. Rodriguez ◽

T. Y. Wang ◽

K. F. Bruggeman ◽

C. C. Horgan ◽

R. Li ◽

...

Keyword(s):

Host Response ◽

Tissue Repair ◽

Neural Progenitor Cells ◽

Cell Delivery ◽

Delivery Vehicle ◽

Self Assembling ◽

A Cell ◽

Peptide Hydrogels ◽

In Vivo Assessment

Functionalized N-fluorenylmethyloxycarbonyl self-assembling peptides are biocompatible in vivo, demonstrating their utility as a cell delivery vehicle for tissue engineering.

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Trimethoxysilyl end-capped hyperbranched polyglycidol/polycaprolactone copolymers for cell delivery and tissue repair: synthesis, characterisation and aqueous solution properties

European Polymer Journal ◽

10.1016/j.eurpolymj.2018.10.030 ◽

2019 ◽

Vol 112 ◽

pp. 648-659 ◽

Cited By ~ 2

Author(s):

Clara González-Chomón ◽

Vasil M. Garamus ◽

Stanislav Rangelov ◽

John R. Ebdon ◽

Christo Novakov ◽

...

Keyword(s):

Aqueous Solution ◽

Tissue Repair ◽

Cell Delivery ◽

Solution Properties ◽

Repair Synthesis

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Delivery of mesenchymal stem cells for tackling systemic disorders

Current Stem Cell Research & Therapy ◽

10.2174/1574888x16666210118123724 ◽

2021 ◽

Vol 16 ◽

Author(s):

Wing-Fu Lai

Keyword(s):

Stem Cells ◽

Stem Cell ◽

Tissue Repair ◽

Current Status ◽

Cell Delivery ◽

Stem Cell Delivery ◽

Technological Advances ◽

Degenerative Disorders ◽

Multiple Injured ◽

The Moment

: Development of methods of manipulating and culturing stem cells has enabled the emergence of stem cell therapy as a promising approach in diverse applications, ranging from tissue repair to treatment of intractable diseases such as diabetes, cardiovascular diseases and neurological disorders. Along with technological advances in systemic stem cell delivery, treating multiple injured or pathological sites simultaneously has been made possible. Despite this, most of the works on systemic stem cell transplantation at the moment have focused on the efficiency of tackling local disorders. The prospect of the therapy for enhancing systemic tissue repair, as well as for tackling systemic degenerative disorders, has rarely been seriously considered. The objective of this article is to fill this gap by reviewing the current status of research on systemic stem cell delivery, and by presenting the opportunities and challenges for translating systemic stem cell delivery from the laboratory to the clinic.

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