scholarly journals Engineering the matrix microenvironment for cell delivery and engraftment for tissue repair

2013 ◽  
Vol 24 (5) ◽  
pp. 864-871 ◽  
Author(s):  
Amy Y Cheng ◽  
Andrés J García
Keyword(s):  
Tissue Repair ◽  
Cell Delivery ◽  
The Matrix

scholarly journals Exploring platelet lysate hydrogel-coated suture threads as biofunctional composite living fibers for cell delivery in tissue repair

2019 ◽  
Vol 14 (3) ◽  
pp. 034104 ◽  
Author(s):  
Raquel Costa-Almeida ◽  
Isabel Calejo ◽  
Roberta Altieri ◽  
Rui M A Domingues ◽  
Emanuele Giordano ◽  
...  
Keyword(s):  
Tissue Repair ◽  
Platelet Lysate ◽  
Cell Delivery

scholarly journals Cardiac Cell Therapy: Insights into the Mechanisms of Tissue Repair

2021 ◽  
Vol 22 (3) ◽  
pp. 1201
Author(s):  
Hsuan Peng ◽  
Kazuhiro Shindo ◽  
Renée R. Donahue ◽  
Ahmed Abdel-Latif
Keyword(s):  
Stem Cell ◽  
Immune Responses ◽  
Tissue Repair ◽  
Molecular Mechanisms ◽  
Clinical Evidence ◽  
Current Knowledge ◽  
Cell Delivery ◽  
Cardiac Cell Therapy ◽  
Stem Cell Treatment

Stem cell-based cardiac therapies have been extensively studied in recent years. However, the efficacy of cell delivery, engraftment, and differentiation post-transplant remain continuous challenges and represent opportunities to further refine our current strategies. Despite limited long-term cardiac retention, stem cell treatment leads to sustained cardiac benefit following myocardial infarction (MI). This review summarizes the current knowledge on stem cell based cardiac immunomodulation by highlighting the cellular and molecular mechanisms of different immune responses to mesenchymal stem cells (MSCs) and their secretory factors. This review also addresses the clinical evidence in the field.

In vivo assessment of grafted cortical neural progenitor cells and host response to functionalized self-assembling peptide hydrogels and the implications for tissue repair

2014 ◽  
Vol 2 (44) ◽  
pp. 7771-7778 ◽  
Author(s):  
A. L. Rodriguez ◽  
T. Y. Wang ◽  
K. F. Bruggeman ◽  
C. C. Horgan ◽  
R. Li ◽  
...  
Keyword(s):  
Host Response ◽  
Tissue Repair ◽  
Neural Progenitor Cells ◽  
Cell Delivery ◽  
Delivery Vehicle ◽  
Self Assembling ◽  
A Cell ◽  
Peptide Hydrogels ◽  
In Vivo Assessment

Functionalized N-fluorenylmethyloxycarbonyl self-assembling peptides are biocompatible in vivo, demonstrating their utility as a cell delivery vehicle for tissue engineering.

Trimethoxysilyl end-capped hyperbranched polyglycidol/polycaprolactone copolymers for cell delivery and tissue repair: synthesis, characterisation and aqueous solution properties

2019 ◽  
Vol 112 ◽  
pp. 648-659 ◽  
Author(s):  
Clara González-Chomón ◽  
Vasil M. Garamus ◽  
Stanislav Rangelov ◽  
John R. Ebdon ◽  
Christo Novakov ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Tissue Repair ◽  
Cell Delivery ◽  
Solution Properties ◽  
Repair Synthesis

Delivery of mesenchymal stem cells for tackling systemic disorders

2021 ◽  
Vol 16 ◽  
Author(s):  
Wing-Fu Lai
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Tissue Repair ◽  
Current Status ◽  
Cell Delivery ◽  
Stem Cell Delivery ◽  
Technological Advances ◽  
Degenerative Disorders ◽  
Multiple Injured ◽  
The Moment

: Development of methods of manipulating and culturing stem cells has enabled the emergence of stem cell therapy as a promising approach in diverse applications, ranging from tissue repair to treatment of intractable diseases such as diabetes, cardiovascular diseases and neurological disorders. Along with technological advances in systemic stem cell delivery, treating multiple injured or pathological sites simultaneously has been made possible. Despite this, most of the works on systemic stem cell transplantation at the moment have focused on the efficiency of tackling local disorders. The prospect of the therapy for enhancing systemic tissue repair, as well as for tackling systemic degenerative disorders, has rarely been seriously considered. The objective of this article is to fill this gap by reviewing the current status of research on systemic stem cell delivery, and by presenting the opportunities and challenges for translating systemic stem cell delivery from the laboratory to the clinic.

scholarly journals Cell Delivery Mechanisms for Tissue Repair

2008 ◽  
Vol 2 (3) ◽  
pp. 205-213 ◽  
Author(s):  
David J. Mooney ◽  
Herman Vandenburgh
Keyword(s):  
Tissue Repair ◽  
Cell Delivery

scholarly journals Programmed cell delivery from biodegradable microcapsules for tissue repair

2015 ◽  
Vol 26 (15) ◽  
pp. 1002-1012 ◽  
Author(s):  
L. Draghi ◽  
D. Brunelli ◽  
S. Farè ◽  
M.C. Tanzi
Keyword(s):  
Tissue Repair ◽  
Cell Delivery

Crystalloid Inclusions in Hepatocyte Mitochondria and Their Similarity to Cytoplasmic Crystalloids

1974 ◽  
Vol 32 ◽  
pp. 198-199
Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Special Interest ◽  
Structural Variations ◽  
Mitochondrial Alterations ◽  
The Matrix ◽  
Crystalloid Inclusions ◽  
Liver Biopsies

Mitochondrial alterations were studied in 25 liver biopsies from patients with alcoholic liver disease. Of special interest were the morphologic resemblance of certain fine structural variations in mitochondria and crystalloid inclusions. Four types of alterations within mitochondria were found that seemed to relate to cytoplasmic crystalloids.Type 1 alteration consisted of localized groups of cristae, usually oriented in the long direction of the organelle (Fig. 1A). In this plane they appeared serrated at the periphery with blind endings in the matrix. Other sections revealed a system of equally-spaced diagonal lines lengthwise in the mitochondrion with cristae protruding from both ends (Fig. 1B). Profiles of this inclusion were not unlike tangential cuts of a crystalloid structure frequently seen in enlarged mitochondria described below.

Coherency loss in γ' precipitates in nickel-base superalloy

1983 ◽  
Vol 41 ◽  
pp. 244-245
Author(s):  
R. A. Ricks ◽  
Angus J. Porter
Keyword(s):  
Lattice Mismatch ◽  
Lattice Parameter ◽  
Nickel Base Superalloy ◽  
Large Size ◽  
The Matrix ◽  
Nimonic 80A ◽  
Interfacial Dislocations ◽  
Nickel Base ◽  
Coherency Loss ◽  
Nimonic 115

During a recent investigation concerning the growth of γ' precipitates in nickel-base superalloys it was observed that the sign of the lattice mismatch between the coherent particles and the matrix (γ) was important in determining the ease with which matrix dislocations could be incorporated into the interface to relieve coherency strains. Thus alloys with a negative misfit (ie. the γ' lattice parameter was smaller than the matrix) could lose coherency easily and γ/γ' interfaces would exhibit regularly spaced networks of dislocations, as shown in figure 1 for the case of Nimonic 115 (misfit = -0.15%). In contrast, γ' particles in alloys with a positive misfit could grow to a large size and not show any such dislocation arrangements in the interface, thus indicating that coherency had not been lost. Figure 2 depicts a large γ' precipitate in Nimonic 80A (misfit = +0.32%) showing few interfacial dislocations.

Influence of Heat Treatments on Microstructures in an Fe-Co-V Alloy

1974 ◽  
Vol 32 ◽  
pp. 512-513
Author(s):  
S. Mahajan ◽  
M. R. Pinnel ◽  
J. E. Bennett
Keyword(s):  
Single Phase ◽  
Alloy Composition ◽  
Supersaturated Solid Solution ◽  
Cell Formation ◽  
Heat Treatments ◽  
Air Cooling ◽  
Iced Brine ◽  
Transmission Electron ◽  
The Matrix ◽  
Bcc Structure

The microstructural changes in an Fe-Co-V alloy (composition by wt.%: 2.97 V, 48.70 Co, 47.34 Fe and balance impurities, such as C, P and Ni) resulting from different heat treatments have been evaluated by optical metallography and transmission electron microscopy. Results indicate that, on air cooling or quenching into iced-brine from the high temperature single phase ϒ (fcc) field, vanadium can be retained in a supersaturated solid solution (α2) which has bcc structure. For the range of cooling rates employed, a portion of the material appears to undergo the γ-α2 transformation massively and the remainder martensitically. Figure 1 shows dislocation topology in a region that may have transformed martensitically. Dislocations are homogeneously distributed throughout the matrix, and there is no evidence for cell formation. The majority of the dislocations project along the projections of <111> vectors onto the (111) plane, implying that they are predominantly of screw character.

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