Potential Use of College of American Pathologists Accredited Biorepositories to Bridge Unmet Need for Medical Refrigeration Using Ultralow Temperature Storage for COVID-19 Vaccine or Drug Storage

P6539Automated detection of atrial fibrillationb based on vocal features analysis

European Heart Journal ◽

10.1093/eurheartj/ehz746.1129 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

G Golovchiner ◽

A Abelow ◽

M Swissa ◽

O Morelli ◽

A Beker

Keyword(s):

Unmet Need ◽

Acoustic Features ◽

Monitoring Tool ◽

Prospective Multicenter Study ◽

Separation Parameter ◽

Specificity And Sensitivity ◽

Pulse Palpation ◽

Esc Guidelines ◽

Potential Use

Abstract Background Early identification of atrial fibrillation (AF) has been a long-standing clinical challenge and an unmet need. AF may be present without the patient being aware of any symptoms, leading to a delay in or failure of diagnosis. ESC guidelines recommend opportunistically screening patients >65 years of age using pulse palpation or an ECG rhythm strip, however these methods have limited effectivity. Analysis of natural speech signals has been used as a monitoring tool for various medical conditions and has recently been reported to enable estimation of heart rate. In this study we evaluated the efficacy of vocal features analysis in the detection of AF and in discriminating between sinus rhythm (SR) and episodes of AF. Methods In this prospective multicenter study, patients with persistent AF admitted for cardioversion were enrolled. A total of 86 patients in 2 centers were included. Prior to cardioversion, the patients spoke specific vowels and words according to a pre-specified protocol; an ECG tracing was simultaneously recorded. Following successful cardioversion and recovery from sedation, these recordings were repeated in SR. The recordings of the first 34 patients were used to develop an algorithm of AF detection based on analysis of acoustic features in SR and AF conditions. The algorithm was then validated in all of the patients (n=86) in the following manner: 25% of SR recordings were used to train the algorithm while the remaining 75% of SR and 100% of AF data from every patient were tested with the algorithm to distinguish between AF and SR. Results A total of 513 recordings from 86 patients were analyzed. Classification of the recordings as AF or SR was performed using varying cutoff values of the separation parameter. The resulting curve showing the specificity and sensitivity of the developed algorithm for distinguishing AF from SR is presented. Two specific examples of working points are a specificity of 92% and sensitivity of 83%, and a specificity of 82% and sensitivity of 92%. Conclusions This study demonstrates the feasibility of detecting AF and discriminating it from SR using analysis of acoustic features extracted from spoken vowels. The potential use of this method for wider population screening should be further evaluated.

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The growth of mica polytypes as studied by conventional and high-resolution TEM

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100074690 ◽

1983 ◽

Vol 41 ◽

pp. 174-177

Author(s):

A. Baronnet ◽

M. Amouric

Keyword(s):

Water Pressure ◽

Point Of View ◽

Temperature Fields ◽

Natural Occurrence ◽

Growth Mechanisms ◽

Long Period ◽

High Resolution Tem ◽

Layer Stacking ◽

Experimental Works ◽

Potential Use

The origin of mica polytypes has long been a challenging problem for crystal- lographers, mineralogists and petrologists. From the petrological point of view, interest in this field arose from the potential use of layer stacking data to furnish further informations about equilibrium and/or kinetic conditions prevailing during the crystallization of the widespread mica-bearing rocks. From the compilation of previous experimental works dealing with the occurrence domains of the various mica "polymorphs" (1Mr, 1M, 2M1, 2M2 and 3T) within water-pressure vs temperature fields, it became clear that most of these modifications should be considered as metastable for a fixed mica species. Furthermore, the natural occurrence of long-period (or complex) polytypes could not be accounted for by phase considerations. This highlighted the need of a more detailed kinetic approach of the problem and, in particular, of the role growth mechanisms of basal faces could play in this crystallographic phenomenon.

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An atomic-resolution microscope study of Al contracts on GaAs

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100145005 ◽

1986 ◽

Vol 44 ◽

pp. 726-727

Author(s):

Z. Liliental-Weber ◽

C. Nelson ◽

R. Ludeke ◽

R. Gronsky ◽

J. Washburn

Keyword(s):

High Speed ◽

Schottky Contacts ◽

Detailed Knowledge ◽

The Past ◽

Semiconductor Interfaces ◽

Deposited Metal ◽

Microwave Applications ◽

Free Interfaces ◽

Potential Use

The properties of metal/semiconductor interfaces have received considerable attention over the past few years, and the Al/GaAs system is of special interest because of its potential use in high-speed logic integrated optics, and microwave applications. For such materials a detailed knowledge of the geometric and electronic structure of the interface is fundamental to an understanding of the electrical properties of the contact. It is well known that the properties of Schottky contacts are established within a few atomic layers of the deposited metal. Therefore surface contamination can play a significant role. A method for fabricating contamination-free interfaces is absolutely necessary for reproducible properties, and molecularbeam epitaxy (MBE) offers such advantages for in-situ metal deposition under UHV conditions

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