The Role of High-Risk Human Papillomavirus-Related Long Non-Coding RNAs in the Prognosis of Cervical Squamous Cell Carcinoma

Abstract LncRNA SRA1 plays important roles in several types of human diseases. The present study aimed to explore the role of SRA1 in cervical squamous cell carcinoma (CSCC). In the present study, we showed that plasma SRA1 was down-regulated in human papillomavirus (HPV)-negative CSCC patients but not in HPV-positive CSCC patients compared with healthy females. Down-regulated SRA1 distinguished HPV-negative CSCC patients from HPV-positive CSCC patients and healthy females. In HPV-negative CSCC patients, miR-9 was up-regulated and inversely correlated with SRA1. In HPV-negative CSCC cells, SRA1 overexpression caused the down-regulated miR-9, while miR-9 overexpression failed to affect SRA1. Moreover, SRA1 overexpression caused decreased, while miR-9 overexpression caused increased proliferation, migration and invasion rates of cancer cells. In addition, miR-9 overexpression attenuated the effects of SRA1 overexpression. Therefore, SRA1 is down-regulated in HPV-negative CSCC and regulates cancer cell behaviors possibly by down-regulating miR-9.

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Reduced expression of autophagy markers correlates with high-risk human papillomavirus infection in human cervical squamous cell carcinoma

Oncology Letters ◽

10.3892/ol.2014.2417 ◽

2014 ◽

Vol 8 (4) ◽

pp. 1492-1498 ◽

Cited By ~ 14

Author(s):

HUA-YI WANG ◽

GUI-FANG YANG ◽

YAN-HUA HUANG ◽

QI-WEN HUANG ◽

JUN GAO ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Human Papillomavirus ◽

High Risk ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cervical Squamous Cell Carcinoma ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection

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High-risk Human Papillomavirus E7 Oncoprotein Detection in Cervical Squamous Cell Carcinoma

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-07-1222 ◽

2007 ◽

Vol 13 (23) ◽

pp. 7067-7072 ◽

Cited By ~ 25

Author(s):

Sigrun Ressler ◽

René Scheiden ◽

Kerstin Dreier ◽

Andreas Laich ◽

Elisabeth Müller-Holzner ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Human Papillomavirus ◽

High Risk ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cervical Squamous Cell Carcinoma ◽

E7 Oncoprotein

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Effect of high-risk human papillomavirus in esophageal squamous cell carcinoma in Somalian and Turkish cases

Pathogens and Disease ◽

10.1093/femspd/ftz047 ◽

2019 ◽

Vol 77 (5) ◽

Cited By ~ 2

Author(s):

Yılmaz Baş ◽

Fügen Vardar Aker ◽

Aylin Gönültaş ◽

Raşit Akdeniz ◽

Ebru Turgal ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Human Papillomavirus ◽

High Risk ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Normal Mucosa ◽

Embedded Blocks ◽

Turkish Patients

ABSTRACT This study aimed to investigate the role of high-risk human papillomavirus (Hr-HPV) in Somalian and Turkish patients with esophageal squamous cell carcinoma (ESCC). In the sections obtained from paraffin-embedded blocks, the results of invasive tumor, peripheral tumor dysplasia and normal mucosa were examined. Samples containing 45 and 47 ESCC, 46 and 42 dysplasia in Somalian (n = 52) and Turkish (n = 53) cases, respectively, were included in the study. We examined the presence of 14 types of Hr-HPV in ESCC collected from Somalia and Turkey by Aptima® Panther System. Hr-HPV types were not detected in Somalian cases. p16INK4a is positive in 5 (11.4%) tumors and 6 (13%) dysplasia. p53 is positive in 28 (62.2%) tumors and 35 (76.1%) dysplasia. HPV16-18/45 are positive only in one of the Turkish cases. p16INK4a is positive in 5 (10.6%) tumors and 4 (9.5%) dysplasia. p53 is positive in 31 (63.3%) tumors and 24 (57.1%) dysplasia. No reaction was detected in normal mucosa samples in both countries. This study is regional. Although the findings did not reflect the general population, the present study shows that the effect of HPV on carcinogenesis in Somalian and Turkish ESCC patients was not significant.

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