Effects of Energy Shots on Blood Pressure in Caffeine-Naive Versus Caffeine-Consuming Healthy Volunteers

Introduction: Urocortin 2 (UCN 2) and urocortin 3 (UCN 3) are endogenous peptide hormones with an emerging role in the pathophysiology and treatment of heart failure. For the first time, we examined the systemic cardiovascular effects of both UCN 2 and UCN 3 in healthy volunteers and patients with heart failure. Methods: Seven healthy volunteers (Group A) and nine patients with stable chronic heart failure (Group B, New York Heart Association class II and III, left ventricular ejection fraction <35%) on optimal medical therapy underwent non-invasive oscillometric sphygmomanometry and impedance cardiography during incremental intravenous infusions of sodium nitroprusside (0.15/0.5/1.5 μg/kg/min), UCN 2 (0.16/0.48/1.6 μg/min), UCN 3 (5/15/50 μg/min) and saline placebo in a randomised double blind two-way cross over study. Results: Other than diastolic blood pressure (78 vs 72 mmHg for Group A and B respectively, p<0.05), haemodynamic variables were similar at baseline of each infusion and were unchanged by saline placebo infusion (p>0.05 for all). SNP, UCN2 and UCN 3 infusions increased heart rate and cardiac index, and reduced systolic and diastolic blood pressure and peripheral vascular resistance index (PVRI) in both healthy volunteers and patients with heart failure (p<0.05 for all; see Figure 1). There were no significant differences in the changes in cardiac index or PVRI between healthy volunteers and patients with heart failure during either UCN 2 or UCN 3 infusions (p>0.05). Conclusion: Intravenous UCN 2 and especially UCN 3 increase cardiac output and reduce peripheral vascular resistance. This favourable haemodynamic profile suggests that UCN 2 and UCN 3 hold exciting therapeutic potential for the treatment of acute heart failure.

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Comparative study on effect of neutral spinal bath and neutral spinal spray on blood pressure, heart rate and heart rate variability in healthy volunteers

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2018-0118 ◽

2018 ◽

Vol 16 (2) ◽

Author(s):

Arundhati Goley ◽

A. Mooventhan ◽

NK. Manjunath

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Heart Rate Variability ◽

Healthy Volunteers ◽

Group Analysis ◽

Low Frequency ◽

Single Session ◽

Arterial Blood ◽

Before And After ◽

Instantaneous Heart Rate

Abstract Background Hydrotherapeutic applications to the head and spine have shown to improve cardiovascular and autonomic functions. There is lack of study reporting the effect of either neutral spinal bath (NSB) or neutral spinal spray (NSS). Hence, the present study was conducted to evaluate and compare the effects of both NSB and NSS in healthy volunteers. Methods Thirty healthy subjects were recruited and randomized into either neutral spinal bath group (NSBG) or neutral spinal spray group (NSSG). A single session of NSB, NSS was given for 15 min to the NSBG and NSSG, respectively. Assessments were taken before and after the interventions. Results Results of this study showed a significant reduction in low-frequency (LF) to high-frequency (HF) (LF/HF) ratio of heart rate variability (HRV) spectrum in NSBG compared with NSSG (p=0.026). Within-group analysis of both NSBG and NSSG showed a significant increase in the mean of the intervals between adjacent QRS complexes or the instantaneous heart rate (HR) (RRI) (p=0.002; p=0.009, respectively), along with a significant reduction in HR (p=0.002; p=0.004, respectively). But, a significant reduction in systolic blood pressure (SBP) (p=0.037) and pulse pressure (PP) (p=0.017) was observed in NSSG, while a significant reduction in diastolic blood pressure (DBP) (p=0.008), mean arterial blood pressure (MAP) (p=0.008) and LF/HF ratio (p=0.041) was observed in NSBG. Conclusion Results of the study suggest that 15 min of both NSB and NSS might be effective in reducing HR and improving HRV. However, NSS is particularly effective in reducing SBP and PP, while NSB is particularly effective in reducing DBP and MAP along with improving sympathovagal balance in healthy volunteers.

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Editorial to accompany “Changes in blood pressure after administration of hydroxocobalamin: Relationship to changes in plasma cobalamins-(III) concentrations in healthy volunteers” (Uhlet al., present edition)

Clinical Toxicology ◽

10.1080/15563650801982553 ◽

2008 ◽

Vol 46 (6) ◽

pp. 576-577

Author(s):

Alan H. Hall

Keyword(s):

Blood Pressure ◽

Healthy Volunteers

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SAFETY OF USE OF HIGH ALTITUDE PROTECTION SUITS FOR KINESITHERAPY – PRELIMINARY REPORT

The Polish Journal of Aviation Medicine Bioengineering and Psychology ◽

10.13174/pjambp.07.12.2020.05 ◽

2020 ◽

Vol 25 (1) ◽

pp. 50-54

Author(s):

Maciej Abakumow ◽

◽

Krzysztof Kowalczuk ◽

Keyword(s):

Blood Pressure ◽

Healthy Volunteers ◽

High Altitude ◽

Cardiovascular System ◽

Preliminary Report ◽

Pressure Increase ◽

Blood Pressure Increase ◽

Safety Considerations ◽

Very High

Abstract: Apart from protection from very high altitude or influence of increased gravitational accelerations protective suits sometimes are used for another applications like supporting kinesitherapy. Because of some safety considerations connected with possible cardiovascular system overload and dangerous blood pressure increase we tested if these concerns are valid. Main aim ot presented research performed with participation of healthy volunteers was to confirm that use of High Altitude Protection (HAP) suit is safe in terms of increased cardiovascular.

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Effect of high nitrate vegetable juice supplementation on plasma nitrate and blood pressure in healthy adults: a pilot randomized crossover intervention in healthy volunteers

10.21203/rs.3.rs-258007/v1 ◽

2021 ◽

Author(s):

Nour Elsahoryi ◽

Christopher Cardwell ◽

Sarah Gilchrist ◽

Jayne Woodside

Keyword(s):

Blood Pressure ◽

Healthy Volunteers ◽

Healthy Adults ◽

Leafy Vegetable ◽

Nitrate Content ◽

Beetroot Juice ◽

Green Leafy Vegetable ◽

Vegetable Juice ◽

Plasma Nitrate ◽

Nitrate And Nitrite

Abstract Background: Beetroot juice has been demonstrated to decrease blood pressure due to the high inorganic nitrate content, but few studies have tested the effect of other high nitrate vegetable juices on blood pressure. Methods: This pilot randomized crossover trial aimed to investigate the effect of two different high nitrate vegetable juices on plasma nitrate concentrations and blood pressure in healthy adults. Eighteen healthy volunteers were randomized to receive 115 ml of beetroot juice or 250 ml of green leafy vegetable juice for seven days. Blood samples were collected, and clinic blood pressure measured at baseline and at the end of each juice consumption. Daily home blood pressure assessment was conducted two hours after juice consumption. Nitrate and nitrite concentrations were analysed using a commercially available kit on a Triturus automated ELISA analyser. Hills and Armitage analysis was used for the two- period crossover design and paired sample t- tests were performed to compare within-group changes. Results: Plasma nitrate and nitrite concentration significantly increased and there was significant reduction in clinic and home SBP mean during the beetroot juice period (P-values 0.004 and 0.002, respectively). Home DBP reduced significantly during green leafy vegetable juice consumption week (P-value 0.03). The difference between groups did not reach statistical significance during the formal crossover analysis adjusted for period effects. Conclusion: Beetroot juice and green leafy vegetable juice may reduce systolic or diastolic blood pressure but there was no statistically significant difference between the two juices, although this was only a pilot study.

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Abstract 399: The Circadian Rhythm of Plasma Angiotensinogen in Healthy Volunteers

Hypertension ◽

10.1161/hyp.60.suppl_1.a399 ◽

2012 ◽

Vol 60 (suppl_1) ◽

Author(s):

Kumiko Kaifu ◽

Hiroyuki Kobori ◽

Yoko Nishijima ◽

Akira Nishiyama ◽

Masakazu Kohno

Keyword(s):

Blood Pressure ◽

Circadian Rhythm ◽

Healthy Volunteers ◽

Pulse Rate ◽

Capillary Tube ◽

Kidney Diseases ◽

Surrogate Marker ◽

Recumbent Position ◽

Time Points ◽

Significant Difference

Background: We have previously reported that urinary angiotensinogen (AGT) excretion did not have a circadian rhythm and could be a novel biomarker for the activity of the renin-angiotensin system (RAS) in kidney. However, there have been few reports investigating the circadian rhythm of plasma AGT in human body. Thus, this study was performed to examine the circadian rhythm in plasma AGT in human. METHODS: Evaluating RAS in clinical practice is generally performed in a recumbent position after a 30-minute stabilization period. However, to determine the necessity of recumbent position, we first compared plasma AGT concentrations measured right after waking up and after a 5-minute sitting rest. Next, we examined the circadian rhythm of plasma AGT in 43 healthy volunteers who had shown no abnormalities in the medical examinations in 2011. Plasma AGT was measured at three time points (9 a.m., 1 p.m., and 4 p.m.) in the above volunteers. Blood was collected by a micro hematocrit capillary tube with heparin, frozen for storage after centrifugation, and thawed for the measurement of plasma AGT using an ELISA kit. Results: There was no significant difference between the plasma AGT values of the two measuring methods (P = 0.1202, n = 5). Based on the result, we performed blood sampling after a 5-minute sitting rest in the volunteers consisting of 17 men and 26 women. Average blood pressure was 116.3/75.1 mmHg at 9 a.m., 116.3/71.9 mmHg at 1 p.m., and 115.5/70.1 mmHg at 4 p.m.; average pulse rate was 78.7/min at 9 a.m., 77.1/min at 1 p.m., and 73.3/min at 4 p.m. Blood pressure and pulse rate did not change throughout the day. Average plasma AGT was 20.4 ± 6.0 ng/ml at 9 a.m., 20.7 ± 5.0 ng/ml at 1 p.m., and 19.8 ± 6.4 ng/ml at 4 p.m. Plasma AGT did not show a circadian rhythm (P = 0.3803). Conclusion: We found in this study that plasma AGT did not have a circadian rhythm. We also found that plasma AGT was not affected by daily life actions. Thus, future patients may not be required to rest nor wait for certain time points before measuring plasma AGT. We also have to unveil the normal AGT levels and the influence on the levels by diseases. As we think that plasma AGT and ratio of urinary AGT to plasma AGT can be a new surrogate marker of hypertension and kidney diseases, we further need to go into this research area.

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Propranolol in Experimentally Induced Stress

The British Journal of Psychiatry ◽

10.1192/bjp.139.6.545 ◽

1981 ◽

Vol 139 (6) ◽

pp. 545-549 ◽

Cited By ~ 3

Author(s):

Elizabeth A. Taylor ◽

Paul Turner ◽

Jean Harrison

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Oral Dose ◽

Systolic Blood Pressure ◽

Healthy Volunteers ◽

The Self ◽

Experimental Stress ◽

Double Blind ◽

Beta Adrenoceptor ◽

Induced Stress

SummaryThe influence of beta-adrenoceptor antagonism on the effects of a simple experimental stress was investigated in 12 healthy volunteers, using a double-blind protocol. A single oral dose of 80 mg propranolol reduced the stress-induced increase in heart rate and systolic blood pressure to 49.9 per cent and 8.3 per cent respectively compared to 61.0 per cent and 17.4 per cent with placebo. The rise in diastolic blood pressure was small and unaffected by beta-adrenoceptor blockade. The rise in temperature of the skin of the trunk was significantly reduced by propranolol. The self-rating of anxiety, alertness and concentration by the subjects was unaffected by propranolol.

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