scholarly journals Successful Fluorescence-Guided Surgery on Human Colon Cancer Patient-Derived Orthotopic Xenograft Mouse Models Using a Fluorophore-Conjugated Anti-CEA Antibody and a Portable Imaging System

2014 ◽  
Vol 24 (4) ◽  
pp. 241-247 ◽  
Author(s):  
Yukihiko Hiroshima ◽  
Ali Maawy ◽  
Cristina A. Metildi ◽  
Yong Zhang ◽  
Fuminari Uehara ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Patient ◽  
Mouse Models ◽  
Imaging System ◽  
Human Colon ◽  
Colon Cancer Patient ◽  
Human Colon Cancer ◽  
Guided Surgery ◽  
Orthotopic Xenograft ◽  
Fluorescence Guided Surgery

scholarly journals Fluorescence-guided surgery of human colon cancer increases complete resection resulting in cures in an orthotopic nude mouse model

2013 ◽  
Vol 179 (1) ◽  
pp. 87-93 ◽  
Author(s):  
Cristina A. Metildi ◽  
Sharmeela Kaushal ◽  
Cynthia S. Snyder ◽  
Robert M. Hoffman ◽  
Michael Bouvet
Keyword(s):  
Colon Cancer ◽  
Mouse Model ◽  
Nude Mouse ◽  
Human Colon ◽  
Complete Resection ◽  
Human Colon Cancer ◽  
Nude Mouse Model ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery

scholarly journals Animal models of gastrointestinal and liver diseases. New mouse models for studying dietary prevention of colorectal cancer

2014 ◽  
Vol 307 (3) ◽  
pp. G249-G259 ◽  
Author(s):  
James C. Fleet
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Mouse Models ◽  
Human Colon ◽  
Low Grade ◽  
Preclinical Models ◽  
Dietary Interventions ◽  
Single Model ◽  
Human Colon Cancer ◽  
Molecular Etiology

Colorectal cancer is a heterogeneous disease that is one of the major causes of cancer death in the U.S. There is evidence that lifestyle factors like diet can modulate the course of this disease. Demonstrating the benefit and mechanism of action of dietary interventions against colon cancer will require studies in preclinical models. Many mouse models have been developed to study colon cancer but no single model can reflect all types of colon cancer in terms of molecular etiology. In addition, many models develop only low-grade cancers and are confounded by development of the disease outside of the colon. This review will discuss how mice can be used to model human colon cancer and it will describe a variety of new mouse models that develop colon-restricted cancer as well as more advanced phenotypes for studies of late-state disease.

A hand-held portable imaging system for effective fluorescence-guided surgery of a pancreatic patient-derived orthotopic xenograft (PDOX) in nude mice.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e15219-e15219
Author(s):  
Yukihiko Hiroshima ◽  
Ali Maawy ◽  
Fuminari Uehara ◽  
Shinji Miwa ◽  
Shuya Yano ◽  
...  
Keyword(s):  
Nude Mice ◽  
Imaging System ◽  
Guided Surgery ◽  
Orthotopic Xenograft ◽  
Fluorescence Guided Surgery

scholarly journals Fluorescent-Antibody Targeting of Insulin-Like Growth Factor-1 Receptor Visualizes Metastatic Human Colon Cancer in Orthotopic Mouse Models

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0146504 ◽  
Author(s):  
Jeong Youp Park ◽  
Takashi Murakami ◽  
Jin Young Lee ◽  
Yong Zhang ◽  
Robert M. Hoffman ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Growth Factor ◽  
Mouse Models ◽  
Fluorescent Antibody ◽  
Human Colon ◽  
Insulin Like Growth Factor ◽  
Human Colon Cancer ◽  
Antibody Targeting
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