Determination of Serum Eosinophil Cationic Protein, Eosinophil Count, and Total IgE in Children with Different Severities of Atopic Diseases

2000 ◽  
Vol 14 (2) ◽  
pp. 109-118 ◽  
Author(s):  
LIDIA PESCOLLDERUNGG ◽  
DIEGO PERONI ◽  
FRANCESCA LOCATELLI ◽  
MARIO PLEBANI ◽  
ATTILIO LORIS BONER
Keyword(s):  
Eosinophil Count ◽  
Eosinophil Cationic Protein ◽  
Atopic Diseases ◽  
Cationic Protein ◽  
Total Ige

Allergic Sensitization and Determination Of Serum Eosinophil Cationic Protein and Triptase In Preschool Population In Hermosillo, Sonora, Mexico

2014 ◽  
Vol 133 (2) ◽  
pp. AB91
Author(s):  
Claudia Gallego-Corella ◽  
Guadalupe Corella ◽  
Andrea Romo ◽  
Antonio Rascón ◽  
Pablo Martínez
Keyword(s):  
Allergic Sensitization ◽  
Eosinophil Cationic Protein ◽  
Cationic Protein

scholarly journals Differentiating the endotypes in allergic rhinitis

2021 ◽  
Vol 36 (2) ◽  
pp. 92-97
Author(s):  
A. V. Klimov ◽  
Z. V. Salahutdinova ◽  
N. A. Pronina ◽  
G. A. Kuznetsov
Keyword(s):  
Allergic Rhinitis ◽  
Eosinophil Cationic Protein ◽  
Skin Tests ◽  
Research Trend ◽  
General Group ◽  
Cationic Protein ◽  
Total Ige ◽  
Interleukin 5 ◽  
Local Allergic Rhinitis ◽  
History Of

Aim. The aim of the study was to differentiate the endotypes in allergic rhinitis by key allergy markers in a mixed group of patients.Material and Methods. The study comprised a total of 48 patients, men and women, aged 18-60 years suffering from three endotypes of allergic rhinitis including the classic, local, and dual allergic rhinitis. The standard diagnostics of allergic rhinitis included taking a history of allergies, family history of allergic disease, video rhinoscopy, serum total IgE level assessment, allergy skin tests to house dust mite and pollen allergens, and study of eosinophilic inflammation parameters (eosinophil cationic protein, interleukin-5 (IL5), and eosinophil counts in blood and nasal secretion).Results. Based on total IgE level, the general group of patients was divided to two subgroups: subgroup 1 comprised patients with high IgE level (n = 22); subgroup 2 comprised patients with low IgE level (n = 26). Most of patients in these groups had contradictory results of allergy skin tests i.e. positive allergy skin test results in case of high IgE level (group 1) and vice versa. Cluster analysis-based exminations of general group allowed to categorize three subgroups of patients: patients with classic allergic rhinitis (n = 22), local allergic rhinitis (n = 22), and dual allergic rhinitis (n = 4). Besides, an increased rate of anxiety disorder was found in patients with local allergic rhinitis (p < 0.001).Conclusion. The obtained data showed promise for a new research trend in studying allergic rhinitis endotypes, namely: investigation of neuroimmune relationships in allergic tolerance disruption in the presence of this pathology.

Influence of total IgE and seasonal increase of eosinophil cationic protein on bronchial hyperreactivity in asthmatic grass-sensitized farmers

Allergy ◽  
2000 ◽  
Vol 55 (11) ◽  
pp. 1030-1034 ◽  
Author(s):  
M. Di Gioacchino ◽  
E. Cavallucci ◽  
F. Di Stefano ◽  
N. Verna ◽  
S. Ramondo ◽  
...  
Keyword(s):  
Eosinophil Cationic Protein ◽  
Bronchial Hyperreactivity ◽  
Cationic Protein ◽  
Total Ige

scholarly journals Study of eosinophil cationic protein serum levels in patients with toxocariasis

2020 ◽  
Vol 2 (3) ◽  
pp. 178-182
Author(s):  
Eleonara Marinova Kaneva ◽  
◽  
Rumen Nenkov Harizanov ◽  
Iskra Georgieva Rainova ◽  
Iskren Tsvetkov Kaftandjiev ◽  
...  
Keyword(s):  
Eosinophil Cationic Protein ◽  
Serum Levels ◽  
Disease Stage ◽  
Confirmatory Test ◽  
Ocular Involvement ◽  
Igg Antibodies ◽  
Serum Samples ◽  
Recent Infection ◽  
Cationic Protein

Introduction: Toxocariasis is a zoonotic helminth infection with difficult diagnosis. Determination of specific IgG antibodies alone does not allow to establish the disease stage and to evaluate the treatment efficacy. Therefore it is necessary to identify additional markers that will assist the diagnosis. The purpose of our study was to identify and monitor eosinophil cationic protein (ECP) levels in patients with toxocariasis confirmed by serology and to compare our data with the literature to determine the relevance of this protein as an indicator for recent infection and the effectiveness of the therapy. Material and methods: ELISA (CUSABIO) commercial kit was used for determination of ECP concentration. Sixty serum samples were studied from individuals previously tested and confirmed for toxocariasis by the presence of specific anti-Toxocara IgG antibodies in ELISA (Toxocara IgG Rbiopharm) and the presence of specific bands in Western blot as confirmatory test (LD BIO). Twenty serum samples from clinically healthy blood donors were used as a control group. Results: The mean concentration of serum ECP in the patients with toxocariasis was significantly higher than in clinically healthy subjects. Seventy-two percent of patients affected by toxicariasis showed increased serum concentration of ECP. However, no statistically significant differences were observed in terms of age (p = 0.451) and sex (p = 0.682) of the patients or clinical form of the disease. ECP levels among patients with visceral toxocariasis were relatively higher (mean 22.99 ng / ml ± 13.16 SD) in comparison to those with ocular involvement (15.60 ng/ml ± 9.92 SD). Correlation between the presence of peripheral eosinophilia and the concentration of serum ECP was not also established. Conclusion: Data from our study give us reason to believe that serum levels of ECP could serve as an additional marker indicating recent infection, especially in patients without marked increase in the blood eosinophils.

Some features of hematological parameters and production of cytokines regulating inflammation in allergic rhinitis

2021 ◽  
Author(s):  
Natalia S. Iraklionova ◽  
Eleonora B. Belan
Keyword(s):  
Allergic Rhinitis ◽  
Hematological Parameters ◽  
Eosinophil Cationic Protein ◽  
Serum Levels ◽  
Normal Serum ◽  
Immune Reactivity ◽  
Cationic Protein ◽  
Total Ige ◽  
Protein Levels ◽  
Serum Total Ige

Backgraund: Allergic rhinitis (AR) is a common IgE-mediated disease. Multiple mechanisms are involved in the regulation of IgE synthesis, and cytokines produced by immune cells play an important role in this process. In addition, the study of the features of immunological reactivity in seasonal AR (SAR) is of interest both getting of new data about pathogenesis of the disease and optimization of the treatment. Aims: To study the features of the cytokine status and hematological parameters in patients with SAR outside the period of exacerbation. Materials and methods: 43 adult patients with SAR (stage of remission) have been included in the study, and 47 conditionally healthy patients have formed the comparison group; perennial symptoms and/or sensitization to perennial allergens were considered as exclusion criteria. Complete blood cell count and serum IL-4, IL-5, IL-6, IL-8, IL-10, IL-18, MCP-1, total IgE, eosinophil cationic protein levels were measured. Results: The remission stage in patients with SAR is characterized by higher serum levels of total IgE and IL-8 compared with the group of healthy patients. Normal serum total IgE level in patients with SAR in remission is associated with activation of the monocyte-macrophage link (increased serum levels of MCP-1, IL-6, IL-8, absolute and relative numbers of monocytes). Increased serum total IgE level is associated with the predominant signs of the Th2-phenotype of the immune response (increased in the serum levels of IL-4, IL-5). Conclusions: Immune reactivity of patients with natural remission of SAR is characterized by Th1-phenotype features if serum level of IgE is normal and Th2-ones if IgE is increased.

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