Medullary Thyroid Cancer: Analyses of Survival and Prognostic Factors and the Role of Radiation Therapy in Local Control

Thyroid ◽  
1996 ◽  
Vol 6 (4) ◽  
pp. 305-310 ◽  
Author(s):  
J. BRIERLEY ◽  
R. TSANG ◽  
W.J. SIMPSON ◽  
M. GOSPODAROWICZ ◽  
S. SUTCLIFFE ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Thyroid Cancer ◽  
Prognostic Factors ◽  
Local Control ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid

Medullary thyroid cancer: the role of radiotherapy in local control

1996 ◽  
Vol 22 (6) ◽  
pp. 588-591 ◽  
Author(s):  
K.M. Fife ◽  
M. Bower ◽  
C.L. Harmer
Keyword(s):  
Thyroid Cancer ◽  
Local Control ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid

YAP confers resistance to vandetanib in medullary thyroid cancer

2020 ◽  
Vol 98 (3) ◽  
pp. 443-448
Author(s):  
Huan Wang ◽  
Jian Tang ◽  
Zhiwei Su
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Critical Role ◽  
Acquired Resistance ◽  
Resistant Cell ◽  
Resistant Cell Line ◽  
Antitumor Effects ◽  
Medullary Thyroid ◽  
Tt Cells

Medullary thyroid cancer (MTC) is the third most common thyroid cancer. RET (Rearranged in Transformation) gene mutations are considered as one of the major drivers of MTC. Vandetanib suppresses RET activity, and has shown promise in clinical trials. Unfortunately, acquired resistance to vandetanib has been observed in MTC, although the mechanism was largely unknown. We investigated the critical role of YAP (Yes-Associated Protein) on vandetanib resistance in MTC. For this, TT cells (medullary thyroid cancer cells) were treated with vandetanib for 3 months to generate a vandetanib-resistant cell line (TT-R). We investigated the role of YAP on vandetanib-resistance in TT-R cells by performing cell proliferation and colony formation assays, and examined the antitumor effects of YAP inhibitor and vandetanib in a mouse model of xenografted MTC. The TT-R cells displayed 6-fold higher IC50 to vandetanib than the TT cells. Overexpression of YAP resulted in resistance to vandetanib, whereas knockdown of YAP re-sensitized the TT-R cells to vandetanib. The YAP inhibitor synergized with vandetanib on tumor inhibition. Our results suggest that YAP plays an important role in acquired resistance to vandetanib in MTC, providing basis for combating MTC with YAP inhibitor and vandetanib.

Medullary Thyroid Cancer: The Role of External Beam Therapy

2016 ◽  
pp. 151-155
Author(s):  
Meredith Elana Giuliani ◽  
James Brierley
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
External Beam ◽  
Medullary Thyroid

Prognostic Factors Influencing Recurrence in Medullary Thyroid Cancer

2008 ◽  
Vol 8 (3) ◽  
pp. 183
Author(s):  
Ju Hee Lee ◽  
Kyu Eun Lee ◽  
Kyung Sik Park ◽  
Do Hoon Ku ◽  
Seung Keun Oh ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Prognostic Factors ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid ◽  
Factors Influencing

The role of human achaete-scute homolog-1 in medullary thyroid cancer cells

Surgery ◽  
2003 ◽  
Vol 134 (6) ◽  
pp. 866-871 ◽  
Author(s):  
Rebecca S Sippel ◽  
Jennifer E Carpenter ◽  
Muthusamy Kunnimalaiyaan ◽  
Herbert Chen
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid ◽  
Thyroid Cancer Cells

Abstract #1082 Ultrasound-Guided Laser Treatment for Local Control of Neck Recurrences of Medullary Thyroid Cancer

2018 ◽  
Vol 24 ◽  
pp. 262
Author(s):  
Enrico Papini ◽  
Antonio Bianchini ◽  
Agnese Persichetti ◽  
Carmela Coccaro ◽  
Rinaldo Guglielmi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Laser Treatment ◽  
Local Control ◽  
Medullary Thyroid Cancer ◽  
Ultrasound Guided ◽  
Medullary Thyroid
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