Medullary Thyroid Cancer: The Role of External Beam Therapy

2016 ◽  
pp. 151-155
Author(s):  
Meredith Elana Giuliani ◽  
James Brierley
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
External Beam ◽  
Medullary Thyroid

YAP confers resistance to vandetanib in medullary thyroid cancer

2020 ◽  
Vol 98 (3) ◽  
pp. 443-448
Author(s):  
Huan Wang ◽  
Jian Tang ◽  
Zhiwei Su
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Critical Role ◽  
Acquired Resistance ◽  
Resistant Cell ◽  
Resistant Cell Line ◽  
Antitumor Effects ◽  
Medullary Thyroid ◽  
Tt Cells

Medullary thyroid cancer (MTC) is the third most common thyroid cancer. RET (Rearranged in Transformation) gene mutations are considered as one of the major drivers of MTC. Vandetanib suppresses RET activity, and has shown promise in clinical trials. Unfortunately, acquired resistance to vandetanib has been observed in MTC, although the mechanism was largely unknown. We investigated the critical role of YAP (Yes-Associated Protein) on vandetanib resistance in MTC. For this, TT cells (medullary thyroid cancer cells) were treated with vandetanib for 3 months to generate a vandetanib-resistant cell line (TT-R). We investigated the role of YAP on vandetanib-resistance in TT-R cells by performing cell proliferation and colony formation assays, and examined the antitumor effects of YAP inhibitor and vandetanib in a mouse model of xenografted MTC. The TT-R cells displayed 6-fold higher IC50 to vandetanib than the TT cells. Overexpression of YAP resulted in resistance to vandetanib, whereas knockdown of YAP re-sensitized the TT-R cells to vandetanib. The YAP inhibitor synergized with vandetanib on tumor inhibition. Our results suggest that YAP plays an important role in acquired resistance to vandetanib in MTC, providing basis for combating MTC with YAP inhibitor and vandetanib.

The role of human achaete-scute homolog-1 in medullary thyroid cancer cells

Surgery ◽  
2003 ◽  
Vol 134 (6) ◽  
pp. 866-871 ◽  
Author(s):  
Rebecca S Sippel ◽  
Jennifer E Carpenter ◽  
Muthusamy Kunnimalaiyaan ◽  
Herbert Chen
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid ◽  
Thyroid Cancer Cells

Medullary thyroid cancer: the role of radiotherapy in local control

1996 ◽  
Vol 22 (6) ◽  
pp. 588-591 ◽  
Author(s):  
K.M. Fife ◽  
M. Bower ◽  
C.L. Harmer
Keyword(s):  
Thyroid Cancer ◽  
Local Control ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid

scholarly journals RMRP, RMST, FTX and IPW: novel potential long non-coding RNAs in medullary thyroid cancer

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Berta Luzón-Toro ◽  
Leticia Villalba-Benito ◽  
Raquel María Fernández ◽  
Ana Torroglosa ◽  
Guillermo Antiñolo ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Potential Role ◽  
Medullary Thyroid Cancer ◽  
Fresh Tissue ◽  
Medullary Thyroid ◽  
Inherited Cancer ◽  
Relevant Role ◽  
Formalin Fixed Paraffin Embedded ◽  
Non Coding Rnas

AbstractThe relevant role of long non-coding RNAs (lncRNAs) in cancer is currently a matter of increasing interest. Medullary thyroid cancer (MTC) is a rare neuroendocrine tumor (2–5% of all thyroid cancer) derived from the parafollicular C-cells which secrete calcitonin. About 75% of all medullary thyroid cancers are believed to be sporadic medullary thyroid cancer (sMTC), whereas the remaining 25% correspond to inherited cancer syndromes known as Multiple Endocrine Neoplasia type 2 (MEN2). MEN2 syndrome, with autosomal dominant inheritance is caused by germline gain of function mutations in RET proto-oncogene. To date no lncRNA has been associated to MEN2 syndrome and only two articles have been published relating long non-coding RNA (lncRNA) to MTC: the first one linked MALAT1 with sMTC and, in the other, our group determined some new lncRNAs in a small group of sMTC cases in fresh tissue (RMST, FTX, IPW, PRNCR1, ADAMTS9-AS2 and RMRP). The aim of the current study is to validate such novel lncRNAs previously described by our group by using a larger cohort of patients, in order to discern their potential role in the disease. Here we have tested three up-regulated (RMST, FTX, IPW) and one down-regulated (RMRP) lncRNAs in our samples (formalin fixed paraffin embedded tissues from twenty-one MEN2 and ten sMTC patients) by RT-qPCR analysis. The preliminary results reinforce the potential role of RMST, FTX, IPW and RMRP in the pathogenesis of MTC.

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