The genetic basis of hereditary medullary thyroid cancer: clinical implications for the surgeon, with a particular emphasis on the role of prophylactic thyroidectomy

2008 ◽  
Vol 15 (4) ◽  
pp. 871-884 ◽  
Author(s):  
G. H Sakorafas ◽  
H. Friess ◽  
G. Peros
Keyword(s):  
Thyroid Cancer ◽  
Genetic Basis ◽  
Medullary Thyroid Cancer ◽  
Clinical Implications ◽  
Prophylactic Thyroidectomy ◽  
Medullary Thyroid ◽  
Hereditary Medullary Thyroid Cancer

scholarly journals Utility of serum thyroglobulin measurements after prophylactic thyroidectomy in patients with hereditary medullary thyroid cancer

Surgery ◽  
2014 ◽  
Vol 156 (2) ◽  
pp. 394-398
Author(s):  
Carolyn D. Seib ◽  
Avital Harari ◽  
Felix A. Conte ◽  
Quan-Yang Duh ◽  
Orlo H. Clark ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Prophylactic Thyroidectomy ◽  
Serum Thyroglobulin ◽  
Medullary Thyroid ◽  
Hereditary Medullary Thyroid Cancer

scholarly journals Indication and Timing of Thyroid Surgery for Patients with Hereditary Medullary Thyroid Cancer Syndromes

2006 ◽  
Vol 4 (2) ◽  
pp. 139-147 ◽  
Author(s):  
Jennifer B. Ogilvie ◽  
Electron Kebebew
Keyword(s):  
Thyroid Cancer ◽  
Multiple Endocrine Neoplasia ◽  
Medullary Thyroid Cancer ◽  
Autosomal Dominant ◽  
Point Mutations ◽  
Prophylactic Thyroidectomy ◽  
Medullary Thyroid ◽  
Hereditary Medullary Thyroid Cancer ◽  
Cancer Syndromes

Hereditary medullary thyroid cancer syndromes comprise familial medullary thyroid cancer (FMTC) and multiple endocrine neoplasia types 2A and 2B. Hereditary medullary thyroid cancers have an autosomal dominant pattern of inheritance and are caused by activating germline point mutations in the RET proto-oncogene. Evaluation of the onset, extent, and progression of hereditary medullary thyroid cancer associated with specific RET mutations has enabled clinicians to treat patients based on the level of risk associated with their specific mutation. Children identified by RET screening to be at risk for the development of medullary thyroid cancer can be treated with prophylactic thyroidectomy before developing the disease. This review covers the diagnosis, evaluation, timing of surgical management, and optimal follow-up of patients with hereditary medullary thyroid cancer syndromes.

YAP confers resistance to vandetanib in medullary thyroid cancer

2020 ◽  
Vol 98 (3) ◽  
pp. 443-448
Author(s):  
Huan Wang ◽  
Jian Tang ◽  
Zhiwei Su
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Critical Role ◽  
Acquired Resistance ◽  
Resistant Cell ◽  
Resistant Cell Line ◽  
Antitumor Effects ◽  
Medullary Thyroid ◽  
Tt Cells

Medullary thyroid cancer (MTC) is the third most common thyroid cancer. RET (Rearranged in Transformation) gene mutations are considered as one of the major drivers of MTC. Vandetanib suppresses RET activity, and has shown promise in clinical trials. Unfortunately, acquired resistance to vandetanib has been observed in MTC, although the mechanism was largely unknown. We investigated the critical role of YAP (Yes-Associated Protein) on vandetanib resistance in MTC. For this, TT cells (medullary thyroid cancer cells) were treated with vandetanib for 3 months to generate a vandetanib-resistant cell line (TT-R). We investigated the role of YAP on vandetanib-resistance in TT-R cells by performing cell proliferation and colony formation assays, and examined the antitumor effects of YAP inhibitor and vandetanib in a mouse model of xenografted MTC. The TT-R cells displayed 6-fold higher IC50 to vandetanib than the TT cells. Overexpression of YAP resulted in resistance to vandetanib, whereas knockdown of YAP re-sensitized the TT-R cells to vandetanib. The YAP inhibitor synergized with vandetanib on tumor inhibition. Our results suggest that YAP plays an important role in acquired resistance to vandetanib in MTC, providing basis for combating MTC with YAP inhibitor and vandetanib.

CD15 (LeuM1) immunoreactivity: Prognostic factor for sporadic and hereditary medullary thyroid cancer?

1994 ◽  
Vol 18 (4) ◽  
pp. 583-587 ◽  
Author(s):  
Friedrich L�ngle ◽  
Thomas Soliman ◽  
Nikolaus Neuhold ◽  
Gerold Widhalm ◽  
Bruno Niederle ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Prognostic Factor ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid ◽  
Hereditary Medullary Thyroid Cancer

Medullary Thyroid Cancer: The Role of External Beam Therapy

2016 ◽  
pp. 151-155
Author(s):  
Meredith Elana Giuliani ◽  
James Brierley
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
External Beam ◽  
Medullary Thyroid
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