scholarly journals Imaging methods in mechanosensing: a historical perspective and visions for the future

2021 ◽  
Vol 32 (9) ◽  
pp. 842-854
Author(s):  
Kirill Lavrenyuk ◽  
Daniel Conway ◽  
Kris Noel Dahl

Recently established microscopic techniques are shedding new light on fundamental questions regarding mechanotransduction. Evidence suggests that myosin motors and the actin cytoskeleton are the single largest aggregate producers and transmitters of force within the cell. We review the roots of this hypothesis and future directions of the field.

Author(s):  
Ataullah Bogdan Kopanski

Abstract There is no agreement among psychologists on sources and outcomes of the dreams in human brain during sleep. Secularist scholars of Freudian school of psychoanalysis claim that human dreams reflect their highly subconscious libido. Jungian school of kollective Unbewessustes   disputes such extreme sexualized opinions and highlights the fact that rather large “collective unconscious” than sexuality is shared by representatives of all human cultures. But even without advanced studies, we can risk to believe that our dreams often predict coming events. Artemidoros Daldianus from Ephesus, the second century CE Hellenistic author of Oneirokritikon believed that dreams are human mind’s mirrors of the future. His magnum opus on the art of interpretation of dreams was translated into Arabic by famous Nestorian ophthalmologist Hunayn ibn Ishaq (Iohannitus) of Bayt al-Hikmah during the reign of Abbasid caliphs Maymun and Mutawakkil. The Prophet Muhammad (s.a.w.) often interpreted his own and Sahabah’s dreams with perfect accuracy. In the Qur’an, especially in Surah 12: Yusuf, 36-37, 99-101, the dreams are vehicles of foretelling the future not only of individuals but also of whole nations and states. The paper is written from historical perspective of the Muslim interpretation of dreams which emphasizes the Islamic examination of human dreams in context of the primary sources to the ancient Greek oneiromancy, studied by the Muslim scholars in the early centuries of Islamic Civilization, and their contribution to development of modern oneirology. Keywords: Oneirology, Interpretation of Dreams, Artemidoros’ Oneirocritica, Islamic Ta‘bÊr. Abstrak Tidak ada sebarang persetujuan di kalangan ahli psikologi terhadap sumber dan hasil daripada mimpi di dalam otak manusia semasa tidur. Para sekular Sekolah Psikoanalisis Freud mendakwa bahawa mimpi manusia mencerminkan kesedaran libido. Sekolah Unbewessustes kollective Jungian pertikaikan pendapat seksual melampau tersebut dan menyerlahkan bahawa kebanyakkan kesedaran bukan daripada kesedaran libido dan didapati dalam semua budaya manusia. Tetapi walaupun tanpa kajian yang canggih, kita boleh mengambil risiko untuk mempercayai bahawa mimpi kita sering meramalkan peristiwa yang akan datang. Artemidoros Daldianus dari Efesus, pengarang Hellenistik Oneirokritikon abad kedua CE percaya bahawa mimpi mencerminkan masa depan manusia. Seni interpretasi mimpi beliau telah diterjemahkan ke dalam Bahasa Arab oleh pakar mata Nestorian terkenal Hunayn ibn Ishaq (Iohannitus) dari Bayt al-Hikmah pada zaman pemerintahan khalifah Abbasiyah Maymun dan Mutawakkil. Nabi Muhammad (s.a.w.) sering mentafsirkan mimpi sendiri dan sahabat secara tepat. Dalam Al-Qur'an, terutamanya dalam Surah 12: Yusuf, 36-37, 99-101, mimpi adalah kenderaan untuk meramalkan masa depan bukan sahaja seorang individu tetapi keseluruhan negara dan negeri. Kajian ini ditulis dari perspektif sejarah interpretasi mimpi Islam yang menekankan pemeriksaan mimpi manusia dalam Islam dalam konteks sumber utama oneiromancy purba Yunani yang dikaji oleh para ulama Islam di abad-abad awal tamadun Islam, dan sumbangan mereka kepada pembangunan oneirologi moden. Kata Kunci: Oneirologi, Interpretasi mimpi, Oneirocritica Artemidoros, Ta‘bÊr Islam.


2020 ◽  
Vol 6 (6) ◽  
pp. 223-244
Author(s):  
Jiaying Xie ◽  
Yiliang Jin ◽  
Kelong Fan ◽  
Xiyun Yan

AbstractArtificial nanorobot is a type of robots designed for executing complex tasks at nanoscale. The nanorobot system is typically consisted of four systems, including logic control, driving, sensing and functioning. Considering the subtle structure and complex functionality of nanorobot, the manufacture of nanorobots requires designable, controllable and multi-functional nanomaterials. Here, we propose that nanozyme is a promising candidate for fabricating nanorobots due to its unique properties, including flexible designs, controllable enzyme-like activities, and nano-sized physicochemical characters. Nanozymes may participate in one system or even combine several systems of nanorobots. In this review, we summarize the advances on nanozyme-based systems for fabricating nanorobots, and prospect the future directions of nanozyme for constructing nanorobots. We hope that the unique properties of nanozymes will provide novel ideas for designing and fabricating nanorobotics.


Eye ◽  
2021 ◽  
Author(s):  
Sana Hamid ◽  
Parul Desai ◽  
Pirro Hysi ◽  
Jennifer M. Burr ◽  
Anthony P. Khawaja

AbstractEffective population screening for glaucoma would enable earlier diagnosis and prevention of irreversible vision loss. The UK National Screening Committee (NSC) recently published a review that examined the viability, effectiveness and appropriateness of a population-based screening programme for primary open-angle glaucoma (POAG). In our article, we summarise the results of the review and discuss some future directions that may enable effective population screening for glaucoma in the future. Two key questions were addressed by the UK NSC review; is there a valid, accurate screening test for POAG, and does evidence exist that screening reduces morbidity from POAG compared with standard care. Six new studies were identified since the previous 2015 review. The review concluded that screening for glaucoma in adults is not recommended because there is no clear evidence for a sufficiently accurate screening test or for better outcomes with screening compared to current care. The next UK NSC review is due to be conducted in 2023. One challenge for POAG screening is that the relatively low disease prevalence results in too many false-positive referrals, even with an accurate test. In the future, targeted screening of a population subset with a higher prevalence of glaucoma may be effective. Recent developments in POAG polygenic risk prediction and deep learning image analysis offer potential avenues to identifying glaucoma-enriched sub-populations. Until such time, opportunistic case finding through General Ophthalmic Services remains the primary route for identification of glaucoma in the UK and greater public awareness of the service would be of benefit.


Author(s):  
Isabel Cepeda ◽  
Pedro Fraile Balbín

ABSTRACT This paper explores Alexis de Tocqueville's thought on fiscal political economy as a forerunner of the modern school of preference falsification and rational irrationality in economic decision making. A good part of the literature has misrepresented Tocqueville as an unconditional optimist regarding the future of fiscal moderation under democracy. Yet, although he initially shared the cautious optimism of most classical economists with respect to taxes under extended suffrage, Tocqueville's view turned more pessimistic in the second volume of his Democracy in America. Universal enfranchisement and democratic governments would lead to higher taxes, more intense income redistribution and government control. Under democracy, the continuous search for unconditional equality would eventually jeopardise liberty and economic growth.


Healthcare ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 244
Author(s):  
Daniele Giansanti

This commentary aims to address the field of social robots both in terms of the global situation and research perspectives. It has four polarities. First, it revisits the evolutions in robotics, which, starting from collaborative robotics, has led to the diffusion of social robots. Second, it illustrates the main fields in the employment of social robots in rehabilitation and assistance in the elderly and handicapped and in further emerging sectors. Third, it takes a look at the future directions of the research development both in terms of clinical and technological aspects. Fourth, it discusses the opportunities and limits, starting from the development and clinical use of social robots during the COVID-19 pandemic to the increase of ethical discussion on their use.


2018 ◽  
Vol 54 (50) ◽  
pp. 6648-6661 ◽  
Author(s):  
Linlin Li ◽  
Siyuan Li ◽  
Yingying Lu

We describe the challenges of high-energy lithium-metal batteries and outline the future directions that are expected to drive their progress.


1978 ◽  
Vol 6 (4) ◽  
pp. 285-292 ◽  
Author(s):  
Robert W. Swezey

A discussion of potential future directions in the areas of simulation and training is presented. Advantages, disadvantages and problems associated with training-oriented simulations are discussed, and several areas including: holography, social processes, mnemonics, trance learning, and electrical and biochemical brain stimulation are presented as fertile areas for increased development in the future.


2016 ◽  
Vol 138 (10) ◽  
Author(s):  
Katherine K. Fu ◽  
Maria C. Yang ◽  
Kristin L. Wood

Design principles are created to codify and formalize design knowledge so that innovative, archival practices may be communicated and used to advance design science and solve future design problems, especially the pinnacle, wicked, and grand-challenge problems that face the world and cross-cutting markets. Principles are part of a family of knowledge explication, which also include guidelines, heuristics, rules of thumb, and strategic constructs. Definitions of a range of explications are explored from a number of seminal papers. Based on this analysis, the authors pose formalized definitions for the three most prevalent terms in the literature—principles, guidelines, and heuristics—and draw more definitive distinctions between the terms. Current research methods and practices with design principles are categorized and characterized. We further explore research methodologies, validation approaches, semantic principle composition through computational analysis, and a proposed formal approach to articulating principles. In analyzing the methodology for discovering, deriving, formulating, and validating design principles, the goal is to understand and advance the theoretical basis of design, the foundations of new tools and techniques, and the complex systems of the future. Suggestions for the future of design principles research methodology for added rigor and repeatability are proposed.


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