scholarly journals 24In-Hospital Adverse Drug Reactions in Hospitalised Older Adults - A Systematic Review

2018 ◽  
Vol 47 (suppl_5) ◽  
pp. v13-v60 ◽  
Author(s):  
Emma Jennings ◽  
Kevin Murphy ◽  
Paul Gallagher ◽  
Denis O’Mahony
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Adverse Drug Reactions ◽  
Drug Reactions

scholarly journals Predicting adverse drug reactions in older adults; a systematic review of the risk prediction models

2014 ◽  
pp. 1581 ◽  
Author(s):  
Jennifer Stevenson ◽  
Josceline L Williams ◽  
Thomas G Burnham ◽  
A Toby Prevost ◽  
Rebekah Schiff ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Risk Prediction ◽  
Adverse Drug Reactions ◽  
Prediction Models ◽  
Drug Reactions ◽  
Risk Prediction Models

scholarly journals In-hospital adverse drug reactions in older adults; prevalence, presentation and associated drugs—a systematic review and meta-analysis

2020 ◽  
Vol 49 (6) ◽  
pp. 948-958 ◽  
Author(s):  
Emma L M Jennings ◽  
Kevin D Murphy ◽  
Paul Gallagher ◽  
Denis O’Mahony
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Adverse Drug Reactions ◽  
Older Patients ◽  
Final Analysis ◽  
Cochrane Library ◽  
Drug Reactions ◽  
Drug Classes ◽  
Clinical Presentations ◽  
Hospitalised Patients

Abstract Background the prevalence of adverse drug reactions (ADRs) in hospitalised older patients, their clinical presentations, causative drugs, severity, preventability and measurable outcomes are unclear, ADRs being an increasing challenge to older patient safety. Methods we systematically searched PubMed, Embase, EBSCO-CINAHL, the Cochrane Library, ‘rey’ literature and relevant systematic review bibliographies, published from database inception to March 2020. We included any study reporting occurrence of in-hospital ADRs as primary or secondary outcomes in hospitalised older adults (mean age ≥ 65 years). Two authors independently extracted relevant information and appraised studies for bias. Study characteristics, ADR clinical presentations, causative drugs, severity, preventability and clinical outcomes were analysed. Study estimates were pooled using random-effects meta-analytic models. Results from 2,399 abstracts, we undertook full-text screening in 286, identifying 27 studies (29 papers). Final analysis yielded a pooled ADR prevalence of 16% (95%CI 12–22%, I2 98%,τ2 0.8585), in a population of 20,153 hospitalised patients aged ≥65 years of whom 2,479 patients experienced ≥ one ADR. ADR ascertainment was highly heterogeneous. Almost 48.3% of all ADRs involved five presentations: fluid/electrolyte disturbances (17.3%), gastrointestinal motility/defaecation disorders (13.3%), renal disorders (8.2%), hypotension/blood pressure dysregulation disorders/shock (5.5%) and delirium (4.1%). Four drug classes accounted for 57.8% of causative medications i.e. diuretics (19.8%), anti-bacterials (14.8%), antithrombotic agents (12.2%) and analgesics (10.9%). Pooled analysis of severity was not feasible. Four studies reported the majority of ADRs as preventable (55–95%). Conclusions on average, 16% of hospitalised older patients experience significant ADRs, varying in severity and mostly preventable, with commonly prescribed drug classes accounting for most ADRs.

Sex Differences in the Risk of Cutaneous Adverse Drug Reactions Induced by Antiseizure Medications: A Systematic Review and Meta-analysis

CNS Drugs ◽  
2021 ◽  
Vol 35 (2) ◽  
pp. 161-176
Author(s):  
Israa Alfares ◽  
Muhammad Shahid Javaid ◽  
Zhibin Chen ◽  
Alison Anderson ◽  
Ana Antonic-Baker ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sex Differences ◽  
Adverse Drug Reactions ◽  
Meta Analysis ◽  
Drug Reactions

scholarly journals Post-Approval Withdrawal of Medicines Because of Adverse Drug Reactions: A Systematic Review

2015 ◽  
Vol 37 (8) ◽  
pp. e30
Author(s):  
I.J. Onakpoya ◽  
C.J. Heneghan ◽  
J.K. Aronson
Keyword(s):  
Systematic Review ◽  
Adverse Drug Reactions ◽  
Drug Reactions

scholarly journals Common Causes and Characteristics of Adverse Drug Reactions in Older Adults: A Retrospective Study

2020 ◽  
Author(s):  
Seong-Dae Woo ◽  
Jiwon Yoon ◽  
Go-Eun Doo ◽  
Youjin Park ◽  
Youngsoo Lee ◽  
...  
Keyword(s):  
Older Adults ◽  
Adverse Drug Reactions ◽  
Drug Reactions ◽  
Younger Patients ◽  
Iodinated Contrast ◽  
Common Causes ◽  
Aging Populations ◽  
Pharmacovigilance Center ◽  
Inflammatory Drugs ◽  
Rate Ratios

Abstract Background: Aging populations are often accompanied by comorbidity and polypharmacy, leading to increases in adverse drug reactions (ADRs). We sought to evaluate the causes and characteristics of ADRs in older Korean adults (≥65 years) in comparison to younger individuals (<65 years). Methods: Of 37,523 cases reported at a Korean pharmacovigilance center from 2011 to 2018, we reviewed 18,842 ADRs of certain or probable causality on the basis of WHO-UMC criteria. We estimated the number of ADRs per 1,000 patients exposed to the major culprit drugs, and incidence rate ratios were obtained to assess high- and low-risk medications in older adults. Results: In total, 4,152 (22.0%) ADRs were reported for 3,437 older adults (mean age, 74.6 years and 57.3% female). Tramadol (rate ratio, 1.32; 95% confidence interval [CI], 1.21-1.44; P <0.001) and fentanyl (1.49, 1.16-1.92, P =0.002) posed higher risks of ADRs in the older adults, whereas nonsteroidal anti-inflammatory drugs (NSAIDs) (0.35, 0.30-0.40, P <0.001) and iodinated contrast media (ICM) (0.82, 0.76-0.89, P <0.001) posed lower risks. Ratios of serious ADRs to NSAIDs (odds ratio, 2.16; 95% CI, 1.48-3.15; P <0.001) and ICM (2.09, 1.36-3.21, P= 0.001) were higher in the older adults than in the younger patients. Analgesics primarily elicited cutaneous ADRs in the younger patients and gastrointestinal reactions in the older adults. ICM more commonly led to anaphylaxis in the older adults than the younger patients (3.0% vs. 1.6%, P =0.019). Conclusion: For early detection of ADRs in older adults, better understanding of differences in the causes and characteristics thereof in comparison to the general population is needed.

scholarly journals Systematic review of pharmacogenomics and adverse drug reactions in paediatric oncology patients

2017 ◽  
Vol 65 (4) ◽  
pp. e26937 ◽  
Author(s):  
Rachel Conyers ◽  
Subalatha Devaraja ◽  
David Elliott
Keyword(s):  
Systematic Review ◽  
Adverse Drug Reactions ◽  
Paediatric Oncology ◽  
Drug Reactions ◽  
Oncology Patients

Older Adults' Response to Analgesic Adverse Drug Reactions: A Pilot Study

2018 ◽  
Vol 19 (4) ◽  
pp. 333-339 ◽  
Author(s):  
Deborah Dillon McDonald ◽  
Sarah Coughlin ◽  
Candy Jin
Keyword(s):  
Older Adults ◽  
Pilot Study ◽  
Adverse Drug Reactions ◽  
Drug Reactions
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