Sex Differences in the Risk of Cutaneous Adverse Drug Reactions Induced by Antiseizure Medications: A Systematic Review and Meta-analysis

CNS Drugs ◽  
2021 ◽  
Vol 35 (2) ◽  
pp. 161-176
Author(s):  
Israa Alfares ◽  
Muhammad Shahid Javaid ◽  
Zhibin Chen ◽  
Alison Anderson ◽  
Ana Antonic-Baker ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sex Differences ◽  
Adverse Drug Reactions ◽  
Meta Analysis ◽  
Drug Reactions

scholarly journals Risk factors for adverse drug reactions in pediatric inpatients: a systematic review

2017 ◽  
Vol 8 (6) ◽  
pp. 199-210 ◽  
Author(s):  
Paulo Henrique Santos Andrade ◽  
Adriano da Silva Santos ◽  
Carlos Adriano Santos Souza ◽  
Iza Maria Fraga Lobo ◽  
Wellington Barros da Silva
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Risk Factor ◽  
Cohort Studies ◽  
Adverse Drug Reactions ◽  
Prescription Drugs ◽  
Data Extraction ◽  
Meta Analysis ◽  
Drug Reactions ◽  
Potential Risk Factors

Background: The main objective of the present systematic review is to identify potential risk factors for adverse drug reactions (ADRs) through prospective cohort studies in pediatric inpatients. Methods: The data search was done in the following electronic databases PubMed/MEDLINE; Scopus; LILACS and Web of Science from the earliest record until 31 May 2015. Two reviewers independently screened each study and one of them assessed the methodological quality according to the Newcastle–Ottawa scale for cohort studies. The data extraction was conducted according to Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) initiative for cohort studies. Results: The only risk factor observed in all studies was the increase in the number of prescription drugs. However, other factors were identified, such as the increase in the length of stay or the number of low- or high-risk drugs prescribed, use of general anesthesia and oncological diagnosis. The cumulative incidence of ADR was 16.4% (95% confidence interval: 15.6 to 17.2). The main professional responsible for ADR identification was the pharmacist and the dominant category among the ADRs were gastrointestinal disorders. In addition, analgesics, antibacterial agents and corticosteroids were the drug classes commonly associated with ADRs. The methodology used in this study was tried to homogenize the data extracted; however, this was not sufficient to correct the discrepancies so it was not possible to perform a meta-analysis. Conclusions: The increase in the number of prescription drugs was the main risk factor in this population. However, additional studies are required to identify the risk factors for ADRs in pediatric inpatients.

scholarly journals Adverse drug reactions during drug-resistant TB treatment in high HIV prevalence settings: a systematic review and meta-analysis

2017 ◽  
Vol 72 (7) ◽  
pp. 1871-1879 ◽  
Author(s):  
Kathryn Schnippel ◽  
Cynthia Firnhaber ◽  
Rebecca Berhanu ◽  
Liesl Page-Shipp ◽  
Edina Sinanovic
Keyword(s):  
Systematic Review ◽  
Adverse Drug Reactions ◽  
Meta Analysis ◽  
Hiv Prevalence ◽  
Drug Resistant ◽  
Drug Reactions ◽  
Tb Treatment

scholarly journals Incidence of adverse drug reactions in paediatric in/out-patients: a systematic review and meta-analysis of prospective studies

2001 ◽  
Vol 52 (1) ◽  
pp. 77-83 ◽  
Author(s):  
Piero Impicciatore ◽  
Imti Choonara ◽  
Amanda Clarkson ◽  
Davide Provasi ◽  
Chiara Pandolfini ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Drug Reactions ◽  
Prospective Studies ◽  
Meta Analysis ◽  
Drug Reactions

A systematic review and meta-analysis of the association between clozapine and norclozapine serum levels and peripheral adverse drug reactions

2021 ◽  
Author(s):  
Madeleine S. A. Tan ◽  
Faraz Honarparvar ◽  
James R. Falconer ◽  
Harendra S. Parekh ◽  
Preeti Pandey ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Drug Reactions ◽  
Meta Analysis ◽  
Serum Levels ◽  
Drug Reactions

Frequency of adverse drug reactions in hospitalized patients: a systematic review and meta-analysis

2012 ◽  
Vol 21 (11) ◽  
pp. 1139-1154 ◽  
Author(s):  
Ana Miguel ◽  
Luís Filipe Azevedo ◽  
Manuela Araújo ◽  
Altamiro Costa Pereira
Keyword(s):  
Systematic Review ◽  
Adverse Drug Reactions ◽  
Meta Analysis ◽  
Hospitalized Patients ◽  
Drug Reactions

scholarly journals Dolutegravir Reported Adverse Drug Reactions: A Systematic Review Protocol

2021 ◽  
Author(s):  
Lesley Wadesango ◽  
Ebenezer Wiafe ◽  
Neelaveni Padayachee ◽  
Kofi Mensah ◽  
Varsha Bangalee
Keyword(s):  
Systematic Review ◽  
Adverse Drug Reactions ◽  
Selection Process ◽  
Data Extraction ◽  
Meta Analysis ◽  
Cochrane Collaboration ◽  
Flow Diagram ◽  
Forest Plot ◽  
Drug Reactions ◽  
Genetic Barrier

Abstract Background: Until recently, the first-line regimen for the management of Human Immunodeficiency Virus (HIV) was Tenofovir (TDF)-Emtricitabine (FTC) and Efavirenz (EFV). However, the use of EFV has now been limited due to adverse neurosensory effects and a low genetic barrier to resistance. This regimen has been replaced by the Dolutegravir (DTG)-based regimen since DTG has a high genetic barrier to resistance. Studies have reported a higher risk of Immune Reconstitution Inflammatory Syndrome (IRIS), weight gain, insomnia, and neural tube defects amongst people who received DTG. This review aims to assess the adverse drug reaction (ADR) profile of Dolutegravir by identifying and classifying Dolutegravir-associated adverse drug reactions.Methods: Studies will be identified from an electronic database search. Studies that are potentially eligible will be selected through screening. Two team members will independently screen all citations, full-text articles, and abstract data; conflicts will be resolved through discussion. The (PRISMA-P) flow diagram that outlines all phases of screening and reasons for exclusion will be used during the selection process. After the selection of the final study sample, a data extraction form will be used as a collection tool. The data will be entered into Cochrane Collaboration Review Manager (RevMan 5.2) for storage and management. All the evidence gathered will be assessed for bias through the use of the Risk of Bias tool RoB 2.0 of Cochrane Collaboration. Reported ADRs will then be classified. We will also provide data for the effect of different demographic factors on ADRs as well as the effects of co-administration of DTG with other drugs on ADRs. We will additionally provide information on how Dolutegravir use in different regimens affects the ADRs. Results from the review will be summarized quantitatively through meta-analysis. A forest plot will be used to present results from the meta-analysis. Conclusion: A review of existing studies will aid in establishing the safety profile of this drug. This review will make significant contributions to healthcare practice. It will aid in improving prescribers' and dispensers’ knowledge of the drug. Additionally, it will also aid in patient education of the potential ADRs to DTG.Systematic review registration DOI: doi.org/10.17605/OSF.IO/Z9YAF

scholarly journals The association between NAT2 acetylator status and adverse drug reactions of sulfasalazine: a systematic review and meta-analysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jeong Yee ◽  
So Min Kim ◽  
Ji Min Han ◽  
Nari Lee ◽  
Ha Young Yoon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Drug Reactions ◽  
Meta Analysis ◽  
Drug Reactions ◽  
Acetylator Status
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