Vitamin A relative dose response test: validation by intravenous injection in children with liver disease

1987 ◽  
Vol 46 (2) ◽  
pp. 286-289 ◽  
Author(s):  
O Amedee-Manesme ◽  
M S Mourey ◽  
A Hanck ◽  
J Therasse
Keyword(s):  
Liver Disease ◽  
Vitamin A ◽  
Intravenous Injection ◽  
Dose Response ◽  
Test Validation ◽  
Response Test

Assessment of the Relative Dose-Response Test as Indicators of Hepatic Vitamin A Stores in Various Stages of Chronic Liver Disease

2012 ◽  
Vol 28 (1) ◽  
pp. 95-100 ◽  
Author(s):  
Wilza Arantes Ferreira Peres ◽  
Gabriela Villaça Chaves ◽  
José Carlos Saraiva Gonçalves ◽  
Andrea Ramalho ◽  
Henrique Sergio Moraes Coelho
Keyword(s):  
Liver Disease ◽  
Vitamin A ◽  
Chronic Liver Disease ◽  
Dose Response ◽  
Chronic Liver ◽  
Response Test

scholarly journals β-Carotene–rich orange-fleshed sweet potato improves the vitamin A status of primary school children assessed with the modified-relative-dose-response test

2005 ◽  
Vol 81 (5) ◽  
pp. 1080-1087 ◽  
Author(s):  
Paul J van Jaarsveld ◽  
Mieke Faber ◽  
Sherry A Tanumihardjo ◽  
Penelope Nestel ◽  
Carl J Lombard ◽  
...  
Keyword(s):  
Vitamin A ◽  
Primary School ◽  
Sweet Potato ◽  
School Children ◽  
Dose Response ◽  
Primary School Children ◽  
Response Test ◽  
Vitamin A Status ◽  
Orange Fleshed Sweet Potato ◽  
Β Carotene

Studies on the application of the relative-dose-response test for assessing vitamin A status in older adults

1992 ◽  
Vol 56 (3) ◽  
pp. 543-547 ◽  
Author(s):  
J Bulux ◽  
E Carranza ◽  
C Castañeda ◽  
N W Solomons ◽  
L J Sokoll ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin A ◽  
Dose Response ◽  
Response Test ◽  
Vitamin A Status

scholarly journals Systematic Review and Meta-Analysis of the Relative Dose-Response Tests to Assess Vitamin A Status

2020 ◽  
Author(s):  
Jesse Sheftel ◽  
Sherry A Tanumihardjo
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Vitamin A ◽  
Chronic Liver Disease ◽  
Dose Response ◽  
Meta Analysis ◽  
Chronic Liver ◽  
Screening Tests ◽  
Demographic And Health Surveys ◽  
The Impact

ABSTRACT Vitamin A (VA) is an essential nutrient often lacking in the diets of people in developing countries. Accurate biomarkers of VA status are vital to inform public health policy and monitor interventions. The relative dose-response (RDR) and modified-RDR (MRDR) tests are semi-quantitative screening tests for VA deficiency that have been used in Demographic and Health Surveys and VA intervention studies. A systematic review and meta-analysis of sensitivity and specificity were conducted to summarize the physiological evidence to support the RDR tests as methods to assess VA status and investigate the impact of different pathological and physiological states on the tests. A total of 190 studies were screened for inclusion, with 21 studies comparing the RDR tests with the gold-standard biomarker, liver VA concentration (68% and 80% sensitivity and 85% and 69% specificity for the RDR and MRDR, respectively). Nearly all studies with VA interventions in VA-deficient populations demonstrated a response of the tests to VA intake that would be expected to improve VA status. The impacts of chronic liver disease, protein malnutrition, age, pregnancy and lactation, infection and inflammation, and various other conditions were examined in 51 studies. The RDR and MRDR tests were reported to have been used in 39 observational studies, and the MRDR has been used in at least 6 national micronutrient surveys. The RDR and MRDR are sensitive tests for determining population VA status and assessing VA interventions. Although they are robust to most physiological and pathological states, caution may be warranted when using the tests in neonates, individuals with chronic liver disease, and those with protein or iron malnutrition. Research on further improvements to the tests to increase accessibility, such as sampling breast milk instead of blood or using intramuscular doses in subjects with malabsorption, will allow wider adoption. This review was registered with PROSPERO as CRD42019124180.

Evaluation of the relative dose response test for vitamin A nutriture in cirrhotics

1981 ◽  
Vol 34 (10) ◽  
pp. 2264-2270 ◽  
Author(s):  
S Mobarhan ◽  
R M Russell ◽  
B A Underwood ◽  
J Wallingford ◽  
R D Mathieson ◽  
...  
Keyword(s):  
Vitamin A ◽  
Dose Response ◽  
Response Test

Oral contraceptives: effect of long-term use on liver vitamin A storage assessed by the relative dose response test

1989 ◽  
Vol 49 (5) ◽  
pp. 845-848 ◽  
Author(s):  
K Amatayakul ◽  
B A Underwood ◽  
S Ruckphaopunt ◽  
R Singkamani ◽  
S Linpisarn ◽  
...  
Keyword(s):  
Vitamin A ◽  
Oral Contraceptives ◽  
Dose Response ◽  
Response Test ◽  
Liver Vitamin
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