scholarly journals Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with iron status in persons with type 2 diabetes mellitus

2007 ◽  
Vol 86 (5) ◽  
pp. 1347-1353 ◽  
Author(s):  
Miguel Arredondo ◽  
Denisse Jorquera ◽  
Elena Carrasco ◽  
Cecilia Albala ◽  
Eva Hertrampf
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Heme Oxygenase ◽  
Iron Status ◽  
Gene Promoter ◽  
Microsatellite Polymorphism ◽  
Heme Oxygenase 1

scholarly journals Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis

2010 ◽  
Vol 172 (6) ◽  
pp. 631-636 ◽  
Author(s):  
Wei Bao ◽  
Fangfang Song ◽  
Xiangyang Li ◽  
Shuang Rong ◽  
Wei Yang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Heme Oxygenase ◽  
Meta Analysis ◽  
Gene Promoter ◽  
Heme Oxygenase 1 ◽  
Promoter Polymorphisms

scholarly journals Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus

PLoS ONE ◽  
2010 ◽  
Vol 5 (8) ◽  
pp. e12371 ◽  
Author(s):  
Wei Bao ◽  
Fangfang Song ◽  
Xiangyang Li ◽  
Shuang Rong ◽  
Wei Yang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1

Functional genetic variants within the SIRT2 gene promoter in type 2 diabetes mellitus

2018 ◽  
Vol 137 ◽  
pp. 200-207 ◽  
Author(s):  
Tingting Liu ◽  
Wentao Yang ◽  
Shuchao Pang ◽  
Shipeng Yu ◽  
Bo Yan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Genetic Variants ◽  
Gene Promoter ◽  
Sirt2 Gene

scholarly journals Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) as A Therapeutical Target in Type-2 Diabetes Mellitus: A Review

2017 ◽  
Vol 9 (2) ◽  
pp. 73 ◽  
Author(s):  
Asri Hendrawati
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Antioxidative Enzymes ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Nuclear Factor ◽  
Expression And Activity

BACKGROUND: Increasing free radicals and oxidative stress due to chronic hyperglycemia in type-2 diabetes mellitus (DM) promotes the activity of endogenic antioxidative genes. Nuclear factor erythroid 2-related factor 2 (Nrf2) expression and activity are important to regulate the production of endogenic antioxidative enzymes.CONTENT: Normally, Nrf2 is bound by protein Kelchlike ECH-associated protein-1 (Keap1) in the cytosol. Stimulation from oxidative stress causes the release of Nrf2 from Keap1. When activated, Nrf2 enters the nucleus and activates the antioxidant response element (ARE). This will further increase the production of antioxidative enzymes, such as catalase, nitrite oxydase and heme oxygenase-1. The discovery of oxidative stress, as the cause of complications in DM, gives rise to the idea of developing a treatment which can increase the expression and activity of Nrf2, one of which is a flavonoid antioxidant.SUMMARY: Currently, nuclear factor erythroid 2-related factor 2 is an important target in the therapy of DM.KEYWORDS: Nrf2, type-2 diabetes mellitus, endogenic antioxidative enzymes, oxidative stress, antioxidants

Lack of association of HFE gene polymorphism with high body iron status in Pakistani patients with type 2 diabetes mellitus

2020 ◽  
pp. 1-16
Author(s):  
Jibran Sualeh Muhammad ◽  
Najmul Islam ◽  
Naseema Mehboobali ◽  
Khalida Iqbal ◽  
Iqbal Azam ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Novel Mutation ◽  
Iron Status ◽  
Hfe Gene ◽  
Healthy Controls ◽  
Body Iron ◽  
Type 2 Dm

Abstract Objective: Aims of this study was to investigate the relationship of 3 common polymorphisms in the HFE gene (C282Y, H63D and S65C) with high body iron status in a population of Pakistani patients with type 2 diabetes mellitus (DM) and to explore if there is any novel mutation in HFE gene in a sample of Pakistani subjects with type 2 DM. Methods: In a case-control design, 200 healthy controls and 200 consecutive adult subjects with type 2 DM (both gender; age range of 30-70 years) were enrolled with informed consent. Their serum samples were analyzed for body iron status (ratio of concentration of soluble transferrin receptor to ferritin concentration). DNA from blood was screened for HFE gene polymorphisms via polymerase chain reaction, followed by restriction fragment length polymorphism or via Sanger sequencing to identify any novel mutation(s) in HFE gene.   Results: We found that there was lack of any association between HFE polymorphism and body iron status in Pakistani subjects with type 2 DM and healthy controls. H63D was the most common polymorphism found in this population.  Single base substitution of G nucleotide instead of C at the codon position 187 in the HFE gene exon 2 was discovered in one subject with DM. There was also a lack of association between D allele (variant allele of H63D) and type 2 DM. A significant relationship was found between CG genotype and abnormal albuminuria in subjects with type 2 DM (p = 0.036). Continuous...    

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