scholarly journals Combined effects of lactotripeptide and aerobic exercise on cognitive function and cerebral oxygenation in middle-aged and older adults

2019 ◽  
Vol 109 (2) ◽  
pp. 353-360 ◽  
Author(s):  
Ai Hamasaki ◽  
Nobuhiko Akazawa ◽  
Toru Yoshikawa ◽  
Kanae Myoenzono ◽  
Koichiro Tanahashi ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Aerobic Exercise ◽  
Cerebral Oxygenation ◽  
Combined Effects ◽  
Middle Aged

The Long Arm of Childhood in China: Early-Life Conditions and Cognitive Function Among Middle-Aged and Older Adults

2017 ◽  
Vol 30 (8) ◽  
pp. 1319-1344 ◽  
Author(s):  
Zhenmei Zhang ◽  
Jinyu Liu ◽  
Lydia Li ◽  
Hongwei Xu
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Memory Performance ◽  
Word Recall ◽  
Middle Aged ◽  
Urban Residence ◽  
Childhood Conditions ◽  
Early Life Conditions ◽  
Childhood Socioeconomic Status ◽  
With Memory

Objective: This study examined the association between childhood conditions and cognitive function among middle-aged and older adults in China. Method: We analyzed data from the 2011 China Health and Retirement Longitudinal Study ( N = 11,868). Cognitive function was measured by word recall, a test of episodic memory. We examined the association between childhood conditions and cognitive function among the middle-aged (45-59 years) and the older (60 years and older) adults separately, using multilevel linear regressions. Results: Indicators of childhood socioeconomic status (SES) and nutrition were significantly associated with memory performance among the middle-aged and the older adults in China. Adulthood SES, education in particular, accounted for some but not all the associations. The protective effect of childhood urban residence was stronger for middle-aged women than for middle-aged men. Discussion: Childhood conditions are significantly associated with mid- to late-life cognitive function in China. The strengths of the associations may vary by gender and cohort.

scholarly journals Link Between Dietary Sodium Intake, Cognitive Function, and Dementia Risk in Middle-Aged and Older Adults: A Systematic Review

2020 ◽  
pp. 1-27
Author(s):  
Devi Mohan ◽  
Kwong Hsia Yap ◽  
Daniel Reidpath ◽  
Yee Chang Soh ◽  
Andrea McGrattan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Cognitive Function ◽  
Sodium Intake ◽  
Dietary Sodium ◽  
Middle Aged ◽  
Dementia Risk

62 Time course of improvement in secretory unbalance of asymmetric dimethylarginine and nitric oxide productions in response to exercise training in middle-aged and older adults

2020 ◽  
Vol 41 (Supplement_1) ◽  
Author(s):  
S Fujie ◽  
N Hasegawa ◽  
K Sanada ◽  
T Hamaoka ◽  
S Maeda ◽  
...  
Keyword(s):  
Older Adults ◽  
Exercise Training ◽  
Arterial Stiffness ◽  
Aerobic Exercise ◽  
Time Course ◽  
Exercise Intervention ◽  
Training Group ◽  
Middle Aged ◽  
Plasma Adma ◽  
Before And After

Abstract Funding Acknowledgements Supported by Grants-in-Aid for Scientific Research (#17H02182, #16K13059, M. Iemitsu; #18J01024, S. Fujie) Introduction Aging is well known to elevate risks of cardiovascular diseases. As a mechanism of these increased risks with aging, a reduction of nitric oxide (NO) production via augmented secretion of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthesis is related. Habitual aerobic exercise has shown to improve secretory unbalance of endothelium-derived regulating factors with aging, such as increase in NO and decrease in ADMA, resulting in the reduction of arterial stiffness. However, the time course of improvement in secretory unbalance of NO and ADMA productions in response to exercise training in middle-aged and older adults remains unclear. Purpose This study aimed to determine the time course of changes in plasma nitrite/nitrate (NOx) and ADMA levels related to exercise-training effects of arterial stiffness in healthy middle-aged and older adults. Methods Thirty-two Japanese healthy middle-aged and older subjects (67 ± 1 years) were randomly divided into two groups: exercise intervention and sedentary controls. Subjects in the training group completed 8-week of aerobic exercise training (60-70% peak oxygen uptake [VO2peak] for 45 min, 3 days/week). We evaluated plasma NOx and ADMA concentrations and carotid-femoral pulse wave velocity (cfPWV) as an index of arterial stiffness, measured every 2 weeks for 8-week in the training group. Results cfPWV was gradually declined from baseline to 8-week and significantly decreased from baseline at weeks 6 (P < 0.05) and 8 (P < 0.01). Plasma NOx level was gradually elevated during exercise intervention and significantly increased from baseline at weeks 6 (P < 0.05) and 8 (P < 0.01). Interestingly, plasma ADMA level was significantly decreased at 8-week intervention (P < 0.05). Furthermore, the exercise training-induced reduction in plasma ADMA level was negatively correlated with the change in plasma NOx level before and after the 8-week (r = -0.483, P < 0.05). The exercise training-induced change in plasma ADMA concentration was positively correlated with training-induced change in cfPWV before and after the 8-week (r = 0.633, P < 0.01). Additionally, there was a negative correlation between the changes in plasma NOx level and cfPWV before and after the 8-week (r = -0.642, P < 0.05). Conclusions These results suggest that habitual aerobic exercise can normalize the secretory unbalance of NO and ADMA productions in 6 to 8 weeks, and these balance normalizations may be contributed to the reduction of arterial stiffness in the middle-aged and older adults.

O4-06-03: Social support, verbal interaction, and cognitive function among middle-aged and older adults in the wisconsin registry for Alzheimer's prevention (WRAP) study

2015 ◽  
Vol 11 (7S_Part_6) ◽  
pp. P281-P281
Author(s):  
Megan Zuelsdorff ◽  
Rebecca L. Koscik ◽  
Ozioma C. Okonkwo ◽  
Sterling C. Johnson ◽  
Corinne D. Engelman
Keyword(s):  
Social Support ◽  
Older Adults ◽  
Cognitive Function ◽  
Verbal Interaction ◽  
Middle Aged

scholarly journals Exploring synergistic effects of aerobic exercise and mindfulness training on cognitive function in older adults

Medicine ◽  
2018 ◽  
Vol 97 (21) ◽  
pp. e10626
Author(s):  
Elena Salmoirago-Blotcher ◽  
Julie DeCosta ◽  
Kristie Harris ◽  
Christopher Breault ◽  
Shira Dunsiger ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Aerobic Exercise ◽  
Synergistic Effects ◽  
Mindfulness Training

scholarly journals Increased serum salusin-α by aerobic exercise training correlates with improvements in arterial stiffness in middle-aged and older adults

Aging ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 1201-1212 ◽  
Author(s):  
Shumpei Fujie ◽  
Natsuki Hasegawa ◽  
Kiyoshi Sanada ◽  
Takafumi Hamaoka ◽  
Seiji Maeda ◽  
...  
Keyword(s):  
Older Adults ◽  
Exercise Training ◽  
Arterial Stiffness ◽  
Aerobic Exercise ◽  
Aerobic Exercise Training ◽  
Middle Aged

scholarly journals Association between tea consumption and cognitive impairment in middle-aged and older adults

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jia Zhang ◽  
Anxin Wang ◽  
Xiaoli Zhang ◽  
Shuohua Chen ◽  
Shouling Wu ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Green Tea ◽  
High Frequency ◽  
Epidemiological Studies ◽  
Neuroprotective Activity ◽  
Tea Consumption ◽  
Older Individuals ◽  
Middle Aged

Abstract Background Biologic studies have suggested that tea may have neuroprotective activity. However, tea’s protective effect on cognitive function is controversial in human epidemiological studies, and no data, including the middle-aged, are available. The objective of this study was to investigate the association of habit, frequency, and types of tea consumption with incident cognitive impairment in middle-aged and older adults. Methods Data from the Asymptomatic Polyvascular Abnormalities in Community study were used (aged over 40y). We gathered information on tea consumption, including habit, frequency, and types, via a standardized questionnaire and assessed cognitive function by Mini-Mental State Examination (MMSE) and/or Montreal Cognitive Assessment (MoCA). Three thousand eight hundred sixty-eight and 806 participants were selected in MMSE and MoCA subgroups. Multivariate logistic regression models were utilized to examine associations between tea consumption and cognitive impairment in middle-aged and older participants. Results In MMSE analyses, after adjustment for potential confounding factors, habitual (odds ratio (OR) 0.47, [95% confidence interval (CI) 0.33–0.68], p < 0.001) and high frequency (p trend < 0.001) of tea intake were associated with a lower risk of cognitive impairment. The risk of cognitive impairment was lower in green tea consumption (OR 0.36, [95% CI 0.22–0.61], p < 0.001) than other types (OR 0.59, [95% CI 0.38–0.91], p = 0.017). In MoCA analyses, we got similar results. Conclusions Habitual tea consumption, especially high-frequency and green tea consumption, was significantly associated with a lower prevalence of cognitive impairment in middle-aged and older individuals.

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