Intraoperative Surgical Specimen Evaluation: Frozen Section Analysis, Cytologic Examination, or Both?: A Comparative Study of 206 Cases

1991 ◽  
Vol 96 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Sharon Mair ◽  
Richard H. Lash ◽  
Dani Suskin ◽  
Geoffrey Mendelsohn
Keyword(s):  
Comparative Study ◽  
Frozen Section ◽  
Cytologic Examination ◽  
Surgical Specimen ◽  
Frozen Section Analysis ◽  
Section Analysis

scholarly journals Frozen Section Analysis and Real-Time Magnetic Resonance Imaging of Surgical Specimen Oriented on 3D Printed Tongue Model to Assess Surgical Margins in Oral Tongue Carcinoma: Preliminary Results

2021 ◽  
Vol 11 ◽  
Author(s):  
Caterina Giannitto ◽  
Giuseppe Mercante ◽  
Luca Disconzi ◽  
Riccardo Boroni ◽  
Elena Casiraghi ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Frozen Section ◽  
Surgical Margin ◽  
Margin Status ◽  
Resection Margins ◽  
Oral Tongue ◽  
Surgical Specimen ◽  
Frozen Section Analysis ◽  
3D Printed ◽  
Section Analysis

BackgroundA surgical margin is the apparently healthy tissue around a tumor which has been removed. In oral cavity carcinoma, a negative margin is considered ≥ 5 mm, a close margin between 1 and 5 mm, and a positive margin ≤ 1 mm. Currently, the intraoperative surgical margin status is based on the visual inspection and tissue palpation by the surgeon and intraoperative histopathological assessment of the resection margins by frozen section analysis (FSA). FSA technique is limited and susceptible to sampling errors. Definitive information on the deep resection margins requires postoperative histopathological analysis.MethodsWe described a novel approach for the assessment of intraoperative surgical margins by examining a surgical specimen oriented through a 3D-printed specific patient tongue with real-time Magnetic Resonance Imaging (MRI). We reported the preliminary results of a case series of 10 patients, prospectively enrolled, with oral tongue carcinoma who underwent surgery between February 2020 and April 2021. Two radiologists with 5 and 10 years of experience, respectively, in Head and Neck radiology in consensus evaluated specimen MRI and measured the distance between the tumor and the specimen surface. We performed intraoperative bedside FSA. To compare the performance of bedside FSA and MRI in predicting definitive margin status we computed the weighted sensitivity (SE), specificity (SP), accuracy (ACC), area under the ROC curve (AUC), F1-score, Positive Predictive Value (PPV), and Negative Predictive Value (NPV). To express the concordance between FSA and ex-vivo MRI we reported the jaccard index.ResultsIntraoperative bedside FSA showed SE of 90%, SP of 100%, F1 of 95%, ACC of 0.9%, PPV of 100%, NPV (not a number), and jaccard of 90%, and ex-vivo MRI showed SE of 100%, SP of 100%, F1 of 100%, ACC of 100%, PPV of 100%, NPV of 100%, and jaccard of 100%. These results needed to be validated in a larger sample size of 21- 44 patients.ConclusionThe presented method allows a more accurate evaluation of surgical margin status, and the first clinical experiences underline the high potential of integrating FSA with ex-vivo MRI of the fresh surgical specimen.

Positive neck margin at frozen section analysis is a significant preditor of tumour recurrence and poor survival after pancreatoduodenectomy for pancreatic cancer

Pancreatology ◽  
2020 ◽  
Vol 20 ◽  
pp. S160-S161
Author(s):  
G. Guarneri ◽  
S. Crippa ◽  
G. Belfiori ◽  
S. Partelli ◽  
M. Pagnanelli ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Frozen Section ◽  
Tumour Recurrence ◽  
Poor Survival ◽  
Frozen Section Analysis ◽  
Section Analysis

Bladder-to-bladder metastasis: gallbladder cancer metastasising to the urinary bladder

2021 ◽  
Author(s):  
S Mukherjee ◽  
J Abbaraju ◽  
G Russell ◽  
S Madaan
Keyword(s):  
Urinary Bladder ◽  
Gallbladder Cancer ◽  
Palliative Chemotherapy ◽  
Frozen Section ◽  
Healthy Woman ◽  
Frozen Section Analysis ◽  
Bladder Metastasis ◽  
Distant Spread ◽  
Bladder Mass ◽  
Section Analysis

We report a 48-year-old fit and healthy woman who was incidentally diagnosed to have adenocarcinoma of gallbladder after laparoscopic cholecystectomy. Subsequent imaging showed no evidence of regional or distant spread. She was scheduled for elective laparotomy and resection of gallbladder bed, but during laparotomy frozen section analysis of an incidentally discovered peritoneal deposit confirmed metastasis, so the procedure was abandoned. Thereafter, she received cisplatin and gemcitabine chemotherapy. However, surveillance computed tomography incidentally noted a urinary bladder mass which had not been present before. Transurethral resection of the bladder lesion revealed moderately differentiated adenocarcinoma of urinary bladder. The appearance and immunoprofile of the lesion confirmed metastasis from the primary gallbladder cancer, which has not been documented in the literature to the best of our knowledge. Her disease progressed and she is being challenged with gemcitabine and carboplatin as second-line palliative chemotherapy. She is still alive two years after the initial diagnosis.

690 ROLE OF FROZEN SECTION ANALYSIS DURING RADICAL PROSTATECTOMY A 2,641-CASE EXPERIENCE

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Yasuhiro Kakiuchi ◽  
Bonnie Choy ◽  
Jennifer Gordetsky ◽  
Guan Wu ◽  
Hani Rashid ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Frozen Section ◽  
Frozen Section Analysis ◽  
Section Analysis

Utility of intraoperative frozen section analysis of surgical margins in region of neurovascular bundles at radical prostatectomy

Urology ◽  
2002 ◽  
Vol 59 (5) ◽  
pp. 709-714 ◽  
Author(s):  
Reza Z Goharderakhshan ◽  
Daniel Sudilovsky ◽  
Lauren A Carroll ◽  
Gary D Grossfeld ◽  
Richard Marn ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Frozen Section ◽  
Surgical Margins ◽  
Intraoperative Frozen Section ◽  
Frozen Section Analysis ◽  
Section Analysis ◽  
Neurovascular Bundles

scholarly journals Frozen section analysis and sentinel lymph node biopsy in well differentiated thyroid cancer

2013 ◽  
Vol 42 (1) ◽  
pp. 48 ◽  
Author(s):  
Yelda Jozaghi ◽  
Keith Richardson ◽  
Sumeet Anand ◽  
Alex Mlynarek ◽  
Michael P Hier ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Differentiated Thyroid Cancer ◽  
Frozen Section ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Frozen Section Analysis ◽  
Well Differentiated ◽  
Section Analysis

scholarly journals Imprint cytology versus frozen section analysis for intraoperative assessment of sentinel lymph node in breast cancer

2017 ◽  
Vol Volume 9 ◽  
pp. 325-330 ◽  
Author(s):  
Thalia Petropoulou ◽  
Antonia Kapoula ◽  
Aikaterini Mastoraki ◽  
Aikaterini Politi ◽  
Eleni Spanidou-Karvouni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Frozen Section ◽  
Imprint Cytology ◽  
Intraoperative Assessment ◽  
Frozen Section Analysis ◽  
Section Analysis
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