Primary Chondroblastic Osteosarcoma of the Breast in a Teenager: What Is Changing?

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S88-S89
Author(s):  
James Yahaya
Keyword(s):  
Triple Negative ◽  
Previous History ◽  
Phyllodes Tumor ◽  
Excisional Biopsy ◽  
Left Breast ◽  
Treatment Modalities ◽  
Large Tumor ◽  
Primary Osteosarcoma ◽  
History Of ◽  
Chondroblastic Osteosarcoma

Abstract Background Nonepithelial tumors of the breast are extremely rare and have an incidence of less than 1%. The most common nonepithelial breast tumor is phyllodes tumor (PT), which accounts for 61%. Primary osteosarcomas of the breast contribute up to only 12.5% of all the extraosseous osteosarcomas, and among young females, they are extremely rare, especially in those without a previous history of primary bone osteosarcoma. A case of a 16-year-old female with primary chondroblastic osteosarcoma of the left breast is herein presented. Case Description In this report, we describe and report a 16-year-old female with neither a previous history of bone osteosarcoma nor a family history of breast cancer who was diagnosed with a primary chondroblastic osteosarcoma of the left breast. The mass was shining, warm, firm, and slightly fixed. The excisional biopsy showed a large tumor measuring 11 × 9 × 7 cm, encapsulated, grayish-white, and nodular. The H&E-stained sections showed a tumor composed of atypical spindle cells, large pleomorphic epithelioid cells, and multinucleated cells of osteoclastic type with osteoid formation with abundant areas having malignant chondroid matrix. About 40 atypical mitoses/10 HPF were seen. A diagnosis of primary osteosarcoma was made. Immunohistochemically, the tumor was triple negative, vimentin was strongly positive, SMA was focally positive, and AE1/AE3 was negative. The patient was put under observation. Her postoperative course is generally promising without any complaint of pain. We present a case of a very young female with the rarest diagnosis of primary osteosarcoma involving the left breast. Conclusion Primary osteosarcomas of the breast carry poor prognosis by being triple negative, and because of being the rarest tumors, they pose a challenge in managing the patients due to lack of established treatment modalities.

A rare case of high-grade chondroblastic osteosarcoma post-radiotherapy for a right frontal oligodendroglioma

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Sinead Horan ◽  
◽  
Oscar Breathnach ◽  
Liam Grogan ◽  
David Fitzpatrick ◽  
...  
Keyword(s):  
Radiation Exposure ◽  
Brain Tumour ◽  
Radiation Field ◽  
Rare Case ◽  
Previous History ◽  
High Grade ◽  
History Of ◽  
Rare Malignancy ◽  
Chondroblastic Osteosarcoma

This is the fourteenth case of an intracranial and dural-based osteosarcoma in the literature to date. The case involves a forty-year old woman with a previous history of a brain tumour, which was treated with surgery, chemotherapy and radiotherapy six years previously. The hypothesis is that this rare malignancy is secondary to the radiation exposure given the growth of the lesion in the previous radiation field

scholarly journals An atypical presentation of extensive centrofacial microcystic adnexal carcinoma responding to radiation: A case report and review of the literature

2020 ◽  
Vol 8 ◽  
pp. 2050313X2095311
Author(s):  
Kelsey Hinther ◽  
Jihane Henni ◽  
Rachel N Asiniwasis
Keyword(s):  
Excisional Biopsy ◽  
Treatment Modalities ◽  
Review Of The Literature ◽  
Micrographic Surgery ◽  
Unique Case ◽  
Clinical Recurrence ◽  
Microcystic Adnexal Carcinoma ◽  
History Of ◽  
Ongoing Assessment ◽  
To Receive

Microcystic adnexal carcinoma is a rare cutaneous neoplasm believed to arise from pluripotent keratinocytes capable of adnexal differentiation. Due to its insidious growth and appearance, diagnosis is often delayed. A deep incisional or excisional biopsy for histopathology is the gold standard for diagnosis. Different treatment modalities have been described in the literature, including the Mohs micrographic surgery, standard excision, radiation, chemotherapy, and observation. Currently, Mohs remains the treatment of choice. We present a unique case of a 12-month history of an extensive progressive centrofacial cutaneous induration diagnosed as microcystic adnexal carcinoma in an 83-year-old female. Due to the extensive nature of the tumor, she received radiation therapy and continues to receive ongoing assessment with no evidence of clinical recurrence at 2-year post-treatment including negative scouting biopsies. To date, there is no consensus on the optimal treatment for microcystic adnexal carcinoma.

scholarly journals Excision of metastatic breast cancer from sternum and reconstruction in two patients with solitary metastatic spread

2020 ◽  
Vol 2020 (8) ◽  
Author(s):  
Saifullah Mohamed ◽  
Khurum Mazhar ◽  
Ahmed Osman ◽  
Akshay Patel ◽  
Lakshmi Srinivasan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Previous History ◽  
Metastatic Breast ◽  
Extent Of Resection ◽  
Left Breast ◽  
Term Survival ◽  
Metastatic Breast Carcinoma ◽  
History Of ◽  
Treated Breast

Abstract Metastatic breast carcinoma is a relatively common clinical entity. However, the prognosis of oligometastatic and polygometastatic disease differs considerably pertaining to five-year survival. Metastatic breast carcinoma to the sternum has been described as early as 1988. We describe two cases in our institution who presented with solitary sternal metastases with a previous history of treated breast cancer. In both cases, there had been a history of previous left breast cancer treated aggressively with surgical resection and adjuvant oncological therapy and maintenance hormonal therapy. Partial sternectomy or total sternectomy for solitary metastatic sternal deposits is well established with relatively low morbidity and mortality and improvement in quality of life and possible improvement in long-term survival. Furthermore, reconstructive options are inherently dependent on extent of resection performed. These techniques can incorporate the use of sternal plates in order to approximate defects and reinforce the sternum in the setting of partial sternectomy.

scholarly journals Adolescent Catatonia Successfully Treated with Lorazepam and Aripiprazole

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Aaron J. Roberto ◽  
Subhash Pinnaka ◽  
Abhishek Mohan ◽  
Hiejin Yoon ◽  
Kyle A. B. Lapidus
Keyword(s):  
Case Report ◽  
Children And Adolescents ◽  
Emotional Distress ◽  
Successful Treatment ◽  
Previous History ◽  
Treatment Modalities ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Significant Impairment ◽  
History Of

Catatonia is especially concerning in children and adolescents. It leads to significant impairment, including emotional distress, difficulty communicating, and other debilitating symptoms. In this case report, we discuss a patient with no previous history of neuroleptic medication or psychotic symptoms, presenting with first-episode catatonia in the presence of disorganized, psychotic thoughts. We then review the catatonia syndrome, citing examples in the literature supporting its underdiagnosis in children and adolescents, and discuss successful treatment modalities. It is important to diagnose and treat catatonia as efficiently as possible, to limit functional and emotional distress to the patient.

scholarly journals Nontuberculous Mycobacterial Endophthalmitis: Case Series and Review of Literature

2020 ◽  
Author(s):  
Warinyupa Pinitpuwadol ◽  
Nattaporn Tesavibul ◽  
Sutasinee Boonsophon ◽  
Darin Sakiyalak ◽  
Sucheera Sarunket ◽  
...  
Keyword(s):  
Previous History ◽  
Case Series ◽  
Clinical Information ◽  
Visual Outcome ◽  
Treatment Modalities ◽  
Endogenous Endophthalmitis ◽  
Treatment Regimens ◽  
Department Of Ophthalmology ◽  
History Of ◽  
Exogenous Endophthalmitis

Abstract Background: To report three cases of nontuberculous mycobacterial (NTM) endophthalmitis following multiple ocular surgeries and to review previous literature in order to study the clinical profile, treatment modalities, and visual outcomes among patients with NTM endophthalmitis.Methods: Clinical manifestation and management of patients with NTM endophthalmitis in the Department of Ophthalmology, Faculty of Medicine, Siriraj hospital, Mahidol University, Bangkok, Thailand were described. In addition, a review of previously reported cases and case series from MEDLINE, EMBASE, and CENTRAL was performed. The clinical information and type of NTM from the previous studies and our cases were summarized.Results: We reported three cases of NTM endophthalmitis caused by M. haemophilum, M. fortuitum and M. abscessus and a summarized review of 112 additional cases previously published. Of 115 patients, there were 101 exogenous endophthalmitis (87.8%) and 14 endogenous endophthalmitis (12.2%). The patients’ age ranged from 13 to 89 years with mean of 60.5±17.7 years with no gender predominance. Exogenous endophthalmitis occurred in both healthy and immunocompromised hosts, mainly caused by cataract surgery (67.3%). In contrast, almost all endogenous endophthalmitis patients were immunocompromised. Among all patients, previous history of tuberculosis infection was identified in 4 cases (3.5%). Rapid growing NTMs were responsible for exogenous endophthalmitis, while endogenous endophthalmitis were commonly caused by slow growers. Treatment regimens consisted of macrolides, fluoroquinolones or aminoglycosides, which were continued for up to 12 months. Initial and final vision were generally worse than 6/60.Conclusions: NTM endophthalmitis is a serious intraocular infection that leads to irreversible loss of vision. The presentation can mimic a chronic recurrent or persistent intraocular inflammation. History of multiple intraocular surgeries or immune-deficiency in patient with chronic panuveitis should raise the practioner’s suspicion of NTM endophthalmitis. Appropriate diagnosis and treatment are important to optimize visual outcome.

scholarly journals Nontuberculous Mycobacterial Endophthalmitis: Case Series and Review Literature

2020 ◽  
Author(s):  
Warinyupa Pinitpuwadol ◽  
Nattaporn Tesavibul ◽  
Sutasinee Boonsophon ◽  
Darin Sakiyalak ◽  
Sucheera Sarunket ◽  
...  
Keyword(s):  
Previous History ◽  
Case Series ◽  
Clinical Information ◽  
Visual Outcome ◽  
Review Literature ◽  
Treatment Modalities ◽  
Endogenous Endophthalmitis ◽  
Department Of Ophthalmology ◽  
History Of ◽  
Exogenous Endophthalmitis

Abstract Background: To report three cases of nontuberculous mycobacterial (NTM) endophthalmitis following multiple ocular surgeries and to review previous literature in order to study the clinical profile, treatment modalities, and visual outcomes among patients with NTM endophthalmitis.Methods: Clinical manifestation and management of patients with NTM endophthalmitis in the Department of Ophthalmology, Faculty of Medicine, Siriraj hospital, Mahidol University, Bangkok, Thailand were described. In addition, a review of previously reported cases and case series from MEDLINE, EMBASE, and CENTRAL was performed. The clinical information and type of NTM from the previous studies and our cases were summarized.Results: We reported three cases of NTM endophthalmitis caused by M. haemophilum, M. fortuitum and M. abscessus and a summarized review of 112 additional cases previously published. Of 115 patients, there were 101 exogenous endophthalmitis (87.8%) and 14 endogenous endophthalmitis (12.2%). The patients’ age ranged from 13 to 89 years with mean of 60.5±17.7 years with no gender predominance. Exogenous endophthalmitis occurred in both healthy and immunocompromised hosts, mainly caused by cataract surgery (67.3%). In contrast, almost all endogenous endophthalmitis patients were immunocompromised. Among all patients, previous history of tuberculosis infection was identified in 4 cases (3.5%). Rapid growing NTMs were responsible for exogenous endophthalmitis, while endogenous endophthalmitis were commonly caused by slow growers. Treatment regimens consisted of macrolides, fluoroquinolones or aminoglycosides, which were continued for up to 12 months. Initial and final vision were generally worse than 6/60.Conclusions: NTM endophthalmitis is a serious intraocular infection that leads to irreversible loss of vision. The presentation can mimic a chronic recurrent or persistent intraocular inflammation. History of multiple intraocular surgeries or immune-deficiency in patient with chronic panuveitis should raise the practioner’s suspicion of NTM endophthalmitis. Appropriate diagnosis and treatment are important to optimize visual outcome.

scholarly journals Nontuberculous Mycobacterial Endophthalmitis: Case Series and Review Literature

2020 ◽  
Author(s):  
Warinyupa Pinitpuwadol ◽  
Nattaporn Tesavibul ◽  
Sutasinee Boonsophon ◽  
Darin Sakiyalak ◽  
Sucheera Sarunket ◽  
...  
Keyword(s):  
Previous History ◽  
Case Series ◽  
Clinical Information ◽  
Visual Outcome ◽  
Review Literature ◽  
Treatment Modalities ◽  
Endogenous Endophthalmitis ◽  
Department Of Ophthalmology ◽  
History Of ◽  
Exogenous Endophthalmitis

Abstract Background: To report three cases of nontuberculous mycobacterial (NTM) endophthalmitis following multiple ocular surgeries and to review previous literature in order to study the clinical profile, treatment modalities, and visual outcomes among patients with NTM endophthalmitis.Methods: Clinical manifestation and management of patients with NTM endophthalmitis in the Department of Ophthalmology, Faculty of Medicine, Siriraj hospital, Mahidol University, Bangkok, Thailand were described. In addition, a review of previously reported cases and case series from MEDLINE was performed. The clinical information and type of NTM from the previous studies and our cases were summarized.Results: We reported three cases of NTM endophthalmitis caused by M. haemophilum, M. fortuitum and M. abscessus and a summarized review of 95 additional cases previously published. Of 98 patients, there were 85 exogenous endophthalmitis (86.7%) and 13 endogenous endophthalmitis (13.3%). The patients’ age ranged from 13 to 89 years with mean of 61.1±18.7 years with no gender predominance. Exogenous endophthalmitis occurred in both healthy and immunocompromised hosts, mainly caused by cataract surgery (62.4%). In contrast, almost all endogenous endophthalmitis patients were immunocompromised. Among all patients, previous history of tuberculosis infection was identified in 4 cases (4.1%). Rapid growing NTMs were responsible for exogenous endophthalmitis, while endogenous endophthalmitis were commonly caused by slow growers. Treatment regimens consisted of macrolides, fluoroquinolones or aminoglycosides, which were continued for up to 12 months. Initial and final vision were generally worse than 6/60.Conclusions: NTM endophthalmitis is a serious intraocular infection that leads to irreversible loss of vision. The presentation can mimic a chronic recurrent or persistent intraocular inflammation. History of multiple intraocular surgeries or immune-deficiency in patient with chronic panuveitis should raise the practioner’s suspicion of NTM endophthalmitis. Appropriate diagnosis and treatment are important to optimize visual outcome.

scholarly journals Nontuberculous Mycobacterial Endophthalmitis: Case Series and Review Literature

2020 ◽  
Author(s):  
Warinyupa Pinitpuwadol ◽  
Nattaporn Tesavibul ◽  
Sutasinee Boonsophon ◽  
Darin Sakiyalak ◽  
Sucheera Sarunket ◽  
...  
Keyword(s):  
Previous History ◽  
Case Series ◽  
Clinical Information ◽  
Visual Outcome ◽  
Review Literature ◽  
Treatment Modalities ◽  
Endogenous Endophthalmitis ◽  
Department Of Ophthalmology ◽  
History Of ◽  
Exogenous Endophthalmitis

Abstract Background: To report three cases of nontuberculous mycobacterial (NTM) endophthalmitis following multiple ocular surgeries and to review previous literature in order to study the clinical profile, treatment modalities, and visual outcomes among patients with NTM endophthalmitis.Methods: Clinical manifestation and management of patients with NTM endophthalmitis in the Department of Ophthalmology, Faculty of Medicine, Siriraj hospital, Mahidol University, Bangkok, Thailand were described. In addition, a review of previously reported cases and case series from MEDLINE was performed. The clinical information and type of NTM from the previous studies and our cases were summarized.Results: We reported three cases of NTM endophthalmitis caused by M. haemophilum, M. fortuitum and M. abscessus and a summarized review of 95 additional cases previously published. Of 98 patients, there were 85 exogenous endophthalmitis (86.7%) and 13 endogenous endophthalmitis (13.3%). The patients’ age ranged from 13 to 89 years with mean of 61.1±18.7 years with no gender predominance. Exogenous endophthalmitis occurred in both healthy and immunocompromised hosts, mainly caused by cataract surgery (62.4%). In contrast, almost all endogenous endophthalmitis patients were either primary or secondary immunocompromised. Among all patients, previous history of tuberculosis infection was identified in 4 cases (4.1%). Rapid growing NTMs were responsible for exogenous endophthalmitis, while endogenous endophthalmitis were commonly caused by slow growers. Treatment regimens consisted of macrolides, fluoroquinolones or aminoglycosides, which were continued for up to 12 months. Initial and final vision were generally worse than 6/60. There were no significant differences of initial and final vision between exogenous and endogenous causes (p=1.000, 0.446, respectively).Conclusions: NTM endophthalmitis is a serious intraocular infection that leads to irreversible loss of vision. The presentation can mimic a chronic recurrent or persistent intraocular inflammation. History of multiple intraocular surgeries or immune-deficiency in patient with chronic panuveitis should raise the practioner’s suspicion of NTM endophthalmitis. Appropriate diagnosis and treatment are important to optimize visual outcome.

scholarly journals Gout tophus in transferred tendons after 33 years: A case report

2021 ◽  
Author(s):  
Fethiye Damla Menkü Özdemir ◽  
Barış Kafa ◽  
Erdi Özdemir ◽  
Nazlı Eylem Alkanat ◽  
Ali Emre Aksu
Keyword(s):  
Histopathological Examination ◽  
Wrist Joint ◽  
Rare Complication ◽  
Previous History ◽  
Excisional Biopsy ◽  
Absorbable Suture ◽  
Suture Materials ◽  
Initial Surgery ◽  
History Of ◽  
The Right

Surgical site gout is an extremely rare complication that is difficult to diagnose, particularly in patients without a history of gout. A 57-year-old male patient was admitted with no previous history of gout, complaining of surgical site gout located at the junction where flexor carpi ulnaris tendon was transferred to extensor digitorum communis tendon after 33 years of the initial surgery. The patient was presented with a progressive swelling over the last three months which was located on the dorsoulnar side of the right wrist joint. Magnetic resonance imaging revealed an iso/hypointense mass. During the excisional biopsy, retained non-absorbable suture materials were observed within the mass. Histopathological examination result was reported as a typical gout tophus. No recurrence was observed after 18 months of follow-up. In conclusion, surgical site gout may be observed at transferred tendons years after the initial surgery.

Diaforodiagnostic dilemma of a breast tumor in a patient with known history of chest sarcoidosis: a diagnostic approach

Open Medicine ◽  
2011 ◽  
Vol 6 (5) ◽  
pp. 537-540
Author(s):  
Thomai Stavrogianni ◽  
Elisavet Psoma ◽  
Olga Nikolaidou ◽  
Ekaterini Xinou ◽  
Persefoni Xirou ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Fine Needle Aspiration Biopsy ◽  
Excisional Biopsy ◽  
Needle Aspiration ◽  
Left Breast ◽  
Pulmonary Sarcoidosis ◽  
Screening Mammography ◽  
Breast Ultrasound ◽  
Fine Needle ◽  
History Of

AbstractBreast sarcoidosis is extremely rare, substantially less frequent than other extrapulmonary manifestations of sarcoidosis. It can mimic a benign or malignant tumor of the breast. We describe the case of a patient with a history of pulmonary sarcoidosis referred to our hospital for a screening mammography. Mammographic findings raised the suspicion for a breast mass. An additional breast ultrasound and fine -needle aspiration biopsy were performed. Finally, patient underwent a excisional biopsy of the left breast and the histopathological report revealed sarcoidosis.

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