Genomic Epidemiology of Complex Disease: The Need for an Electronic Evidence-based Approach to Research Synthesis

Abstract Background Women living with HIV (WLH) lack evidence-based information about reproductive options while managing pressures from family, clinicians, and communities to give up the idea of having children. As the reproduction intentions of WLH are not well understood, stigmatizing behaviors force them to hide their disease to avoid rejection by their family, partner, and social networks. Compliance with social norms, fear of stigma, and discrimination influence their experience. Current research is individual qualitative studies lacking the synthesis perspective necessary to guide intervention development. The purpose of this study was to synthesize the evidence to explain the reproductive decision-making process for WLH in developed countries. Methods A systematic review with qualitative research synthesis was conducted through searches in 10 electronic databases (CINAHL, EMBASE, MEDLINE, Scopus, Social Science Citation Index, Web of Science, Google Scholar, Cuidatge, Cuiden Enfispo, and SciELO). Studies published in journals from 1995 to 2019 with qualitative data about reproductive decision-making among WLH in developed countries were eligible for inclusion. Developed country was operationalized by membership in the OECD for comparative conditions of social wellbeing and economic stability. The CASP and JBI checklists for qualitative research were used to assess study quality and methodological integrity. Thematic analysis and qualitative meta-summary techniques were used for the synthesis. Results Twenty studies from 12 developed countries were included in the synthesis. Findings were organized into 3 meta-themes from 15 themes and 45 subthemes, including: (1) Shattered identity, (2) Barriers, inequities, and misinformation, (3) Coping, resiliency, and support. Reproductive decision-making was perceived as a complex process influenced by facilitators and barriers. The facilitators helped WLH cope with their new situation to become more resilient, while the barriers made their situation more difficult to manage. Conclusion WLH encounter reproductive decision-making with knowledge deficits and limited social support. An integrated approach to holistic care with comprehensive multidisciplinary counseling is needed to support WLH. Clinicians could benefit from professional development to learn how to be authentically present for WLH, including engaging in conversations, demonstrating compassion, and understanding situations. Evidence-based clinical practice guidelines need to be tailored for the family planning and sexual health needs of WLH.

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Evidence‐based policy: nursing now and the importance of research synthesis

International Nursing Review ◽

10.1111/inr.12572 ◽

2020 ◽

Vol 67 (1) ◽

pp. 52-60 ◽

Cited By ~ 3

Author(s):

D.C. Benton ◽

M.J. Watkins ◽

C.J. Beasley ◽

S.L. Ferguson ◽

A. Holloway

Keyword(s):

Research Synthesis ◽

Evidence Based ◽

Evidence Based Policy

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Towards evidence-based management of external resources: Developing design propositions and future research avenues through research synthesis

Research Policy ◽

10.1016/j.respol.2017.04.002 ◽

2017 ◽

Vol 46 (6) ◽

pp. 1087-1105 ◽

Cited By ~ 10

Author(s):

Kari Tanskanen ◽

Tuomas Ahola ◽

Anna Aminoff ◽

Johanna Bragge ◽

Riikka Kaipia ◽

...

Keyword(s):

Research Synthesis ◽

Future Research ◽

Evidence Based ◽

External Resources

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Harnessing the potential of the primary healthcare facilities in India to respond COVID-19 pandemic: A scoping evidence-based research synthesis

Journal of Family Medicine and Primary Care ◽

10.4103/jfmpc.jfmpc_1609_20 ◽

2021 ◽

Vol 10 (1) ◽

pp. 116

Author(s):

Vaibhav Kumar ◽

Abhishek Royal ◽

MarceloAmaral Mali ◽

IndraniAlhad Wagh ◽

Shashi Bhushan ◽

...

Keyword(s):

Primary Healthcare ◽

Research Synthesis ◽

Evidence Based ◽

Healthcare Facilities

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Integrative Addiction and Recovery

10.1093/med/9780190275334.001.0001 ◽

2018 ◽

Keyword(s):

Complex Disease ◽

Treatment Guidelines ◽

Evidence Based ◽

Equine Therapy ◽

12 Steps ◽

Different Types ◽

Drug Overdoses ◽

Sedative Hypnotics ◽

Definition Of ◽

Substances Of Abuse

Integrative Addiction and Recovery is a book discussing the epidemic of addiction that is consuming our friends, family, and community nationwide. In 2016, there were 64,000 drug overdoses, and addiction became the top cause of accidental death in America in 2015. We are in a crisis and in need of a robust and integrated solution. We begin with the definition of addiction, neurobiology of addiction, and the epidemiology of varying substances of abuse and treatment guidelines. Section II reviews different types of addiction such as food, alcohol, sedative-hypnotics, cannabis, stimulants (such as cocaine and methamphetamine), opiates (including prescription and illicit opiates), and tobacco, and evidence-based approaches for their treatment using psychotherapy, pharmacotherapy, as well as holistic treatments including acupuncture, nutraceuticals, exercise, yoga, and meditation. We also have chapters on behavioral addictions and hallucinogens. Section III reviews co-occurring disorders and their evidence-based integrative treatment and also overviews the holistic therapeutic techniques such as acupuncture and TCM, Ayurveda, homeopathy, nutrition, nutraceuticals, art and aroma therapy, and equine therapy as tools for recovery. We have unique chapters on shamanism and ibogaine, as well as spirituality and group support (12 steps included). The final section deals with challenges facing recovery such as trauma, acute/chronic pain, and post acute withdrawal. Integrative Addiction and Recovery is an innovative and progressive textbook, navigating this complex disease with the most comprehensive approach.

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