scholarly journals Anticipate and Communicate: Ethical Management of Incidental and Secondary Findings in the Clinical, Research, and Direct-to-Consumer Contexts (December 2013 Report of the Presidential Commission for the Study of Bioethical Issues)

2014 ◽  
Vol 180 (6) ◽  
pp. 562-564 ◽  
Author(s):  
C. Weiner
Keyword(s):  
Clinical Research ◽  
Secondary Findings ◽  
Ethical Management ◽  
Direct To Consumer ◽  
Presidential Commission ◽  
Bioethical Issues

Considering Actionability at the Participant's Research Setting Level for Anticipatable Incidental Findings from Clinical Research

2015 ◽  
Vol 43 (3) ◽  
pp. 619-632
Author(s):  
Alberto (Betto) Ortiz-Osorno ◽  
Linda A. Ehler ◽  
Judith Brooks
Keyword(s):  
Clinical Research ◽  
Incidental Finding ◽  
Evaluation Process ◽  
Research Participant ◽  
Secondary Findings ◽  
Potential Health ◽  
Direct To Consumer ◽  
Presidential Commission ◽  
Bioethical Issues ◽  
Conducting Research

Wolf et al. define an incidental finding (IF) as “... a finding concerning an individual research participant that has potential health or reproductive importance and is discovered in the course of conducting research but is beyond the aims of the study...” Wolf et al. also propose that researchers “... should consider what kinds of IFs the protocol may produce and how rapidly the identification and evaluation process needs to proceed to provide timely information to the research participant and avoid harm.”Recently, the U.S. Presidential Commission for the Study of Bioethical Issues considered the matter of IFs. In the Commission's December 2013 report on this topic, “Anticipate and Communicate–Ethical Management of Incidental and Secondary Findings in the Clinical, Research, and Direct-to-Consumer Contexts,” the panel further defines two categories of IFs, anticipatable and un-anticipatable, as well as introduces the concept of secondary findings. The commission recommends that researchers should develop plans to manage anticipatable IFs, and should consider to actively look for secondary findings.

scholarly journals Sustainability and Anticipatory Governance in Synthetic Biology

2012 ◽  
Vol 3 (2) ◽  
pp. 25-38 ◽  
Author(s):  
Arnim Wiek ◽  
David Guston ◽  
Emma Frow ◽  
Jane Calvert
Keyword(s):  
Synthetic Biology ◽  
Sustainability Science ◽  
Anticipatory Governance ◽  
Presidential Commission ◽  
Core Set ◽  
Challenges And Opportunities ◽  
Bioethical Issues ◽  
Transformational Sustainability Science ◽  
The U.S

A prominent imaginary of synthetic biology is the sustainability of bio-based technologies. In this paper, the authors discuss various reports, papers, and activities in synthetic biology in relation to a core set of principles of sustainability, paying particular attention to the concept of “prudent vigilance” as introduced by the report by the U.S. Presidential Commission for the Study of Bioethical Issues. The authors introduce two additional concepts – anticipatory governance and transformational sustainability science – and outline an approach for systematically incorporating sustainability considerations into the development of synthetic biology that addresses the challenges and opportunities presented by the field in a more robust way than prudent vigilance. The authors conclude that an opportunity exists to shape synthetic biology toward sustainable outcomes and make recommendations for how research funders might seize this opportunity.

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