scholarly journals Smokeless Tobacco Use and the Risk of Head and Neck Cancer: Pooled Analysis of US Studies in the INHANCE Consortium

2016 ◽  
Vol 184 (10) ◽  
pp. 703-716 ◽  
Author(s):  
Annah B. Wyss ◽  
Mia Hashibe ◽  
Yuan-Chin Amy Lee ◽  
Shu-Chun Chuang ◽  
Joshua Muscat ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Tobacco Use ◽  
Neck Cancer ◽  
Smokeless Tobacco ◽  
Pooled Analysis ◽  
Us Studies ◽  
Smokeless Tobacco Use

scholarly journals Racial differences in the relationship between tobacco, alcohol, and the risk of head and neck cancer: pooled analysis of US studies in the INHANCE Consortium

2018 ◽  
Vol 29 (7) ◽  
pp. 619-630 ◽  
Author(s):  
Kristin J. Voltzke ◽  
Yuan-Chin Amy Lee ◽  
Zuo-Feng Zhang ◽  
Jose P. Zevallos ◽  
Guo-Pei Yu ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Racial Differences ◽  
Neck Cancer ◽  
Pooled Analysis ◽  
Us Studies ◽  
The Relationship

NF-κB1 intronic region polymorphisms as risk factor for head and neck cancer in HPV-infected population from Pakistan

2021 ◽  
Vol 21 ◽  
Author(s):  
Sumaira Sarwar ◽  
Muammad Usman Tareen ◽  
Maimoona Sabir ◽  
Aneesa Sultan ◽  
Salman A Malik
Keyword(s):  
Head And Neck Cancer ◽  
Lymph Nodes ◽  
Head And Neck ◽  
Tobacco Use ◽  
Neck Cancer ◽  
Direct Sequencing ◽  
Hpv Infection ◽  
Pakistani Population ◽  
Specific Pcr ◽  
Increased Risk

Background: Head and neck cancer (HNC) developed due to the number of risk factors, including infection of Human Papillomavirus (HPV). The genetic predisposition also plays an important role in deregulating the NF-κB pathway, and certain polymorphisms are reported to affect the pathway genes. Objectives: The present study was conducted for the detection of HPV and polymorphisms in the NF-κB1 gene of HNC patients in the Pakistani population. Methods: Genomic DNA from HNC tumors samples were extracted using the Exgene SV DNA extraction Kit. Allele-specific PCR and direct sequencing were done for analysis of NF-κB1 SNPs, 94ins/del (rs28362491), rs1598858, and rs4648068. Results: The genotypes AG (36.2%/ 12%) of rs1598858, and AG (28.3%/ 12%) and GG (28.3%/ 22%) of rs4648068 were associated with significantly (p≤0.05) increased risk of head and neck cancer in studied population. Furthermore, among the HNC cases, genotypes AGrs1598858 (p≤0.014) and GGrs4648068 (p≤0.001) had increased risk of HPV related cancers. Tobacco use (OR-3.158442; [1.140, 8.754]), lymph nodes involvement (OR 4.05128; [1.854, 8.852]), and poorly differentiated tumors (OR 1.997155; [0.940, 4.245]) were positively associated with HPV induced cancers. Conclusion: It was the first comprehensive study from Pakistan, to evaluate the polymorphic variants of NF-κB1. Genotypes AGrs4648068, GGrs4648068, and AGrs1598858 of NF-κB1 gene are associated with increased risk of head and neck cancers in the Pakistani population. It can be concluded that HPV infection, lymph nodes and tobacco use can act synergetic to each other and add up in modulating HNC when present together with intronic SNPs of NF-κB1 gene.

scholarly journals Dietary glycaemic index, glycaemic load and head and neck cancer risk: a pooled analysis in an international consortium

2020 ◽  
Vol 122 (6) ◽  
pp. 745-748 ◽  
Author(s):  
Chun-Pin Chang ◽  
Carlo La Vecchia ◽  
Diego Serraino ◽  
Andrew F. Olshan ◽  
Jose P. Zevallos ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Cancer Risk ◽  
Head And Neck ◽  
Neck Cancer ◽  
Glycaemic Index ◽  
Pooled Analysis ◽  
International Consortium ◽  
Glycaemic Load

scholarly journals Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries

2014 ◽  
Vol 136 (5) ◽  
pp. 1125-1139 ◽  
Author(s):  
David I. Conway ◽  
Darren R. Brenner ◽  
Alex D. McMahon ◽  
Lorna M.D. Macpherson ◽  
Antonio Agudo ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Cancer Risk ◽  
Head And Neck ◽  
Neck Cancer ◽  
Pooled Analysis ◽  
Case Control ◽  
Case Control Studies

scholarly journals Marijuana Smoking and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium

2009 ◽  
Vol 18 (5) ◽  
pp. 1544-1551 ◽  
Author(s):  
Julien Berthiller ◽  
Yuan-chin Amy Lee ◽  
Paolo Boffetta ◽  
Qingyi Wei ◽  
Erich M. Sturgis ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Pooled Analysis

scholarly journals Family history of cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

2009 ◽  
Vol 124 (2) ◽  
pp. 394-401 ◽  
Author(s):  
Eva Negri ◽  
Paolo Boffetta ◽  
Julien Berthiller ◽  
Xavier Castellsague ◽  
Maria Paula Curado ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Family History ◽  
Head And Neck ◽  
Neck Cancer ◽  
Pooled Analysis ◽  
Cancer Epidemiology ◽  
Family History Of Cancer ◽  
History Of ◽  
History Of Cancer
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