scholarly journals Association of DNA Methylation-Based Biological Age With Health Risk Factors and Overall and Cause-Specific Mortality

2017 ◽  
Vol 187 (3) ◽  
pp. 529-538 ◽  
Author(s):  
Pierre-Antoine Dugué ◽  
Julie K Bassett ◽  
JiHoon E Joo ◽  
Laura Baglietto ◽  
Chol-Hee Jung ◽  
...  
Author(s):  
Ting Jiang ◽  
Xue Li ◽  
Li Ning ◽  
Jiwen Liu

The incidence of psychological problems among occupational groups is becoming increasingly more serious, and adverse psychological conditions will seriously affect the working ability of occupational groups and harm the health of their bodies. This study adopted a multi-stage stratified cluster sampling method to conduct a cross-sectional survey on the mental health of 3631 oil workers in Karamay, Xinjiang from March 2017 to June 2018. The mental health status of oil workers was evaluated using the Symptom Checklist-90, and mental health risk factors were evaluated. The correlation between the monoamine oxidase A (MAOA) gene and mental health was analyzed, and the DNA methylation level of the MAOA gene was compared between the normal group and the abnormal group. The results show the incidence of mental health problems among oil workers according to differences in age, nationality, type of work, length of service, professional title, shift work, and marital status. The evaluation of mental health risk factors revealed that shift work, occupational stress, and high payment/low return affect mental health. The somatization scores of different genotypes of rs6323 in the MAOA gene were statistically significant (p < 0.05), suggesting that the somatization scores of different genotypes of rs6323 were different. According to the average rank, the TT genotype group had the highest score, followed by the GT genotype group, and the GG genotype group had the lowest score. The level of DNA methylation in the abnormal group was lower than that in the normal group (p < 0.05). The results suggested that occupational mental health can be enhanced by improving shift work, reducing stress, and balancing effort and reward. This preliminary investigation suggests that methylation status can affect mental health, indicating that methylation level may be a predictor of mental health status.


2000 ◽  
Author(s):  
Paul A. Thomas ◽  
Jen Hanley ◽  
Christy Tomczak ◽  
Jennifer Wuchteil ◽  
Nathan Underwood ◽  
...  

2020 ◽  
Author(s):  
Junhan Cho ◽  
Lorraine I. Kelley-Quon ◽  
Jessica L. Barrington-Trimis ◽  
Afton Kechter ◽  
Sarah Axeen ◽  
...  

2021 ◽  
pp. 026010602199693
Author(s):  
Prince Atorkey ◽  
Mariam Akwei ◽  
Winifred Asare-Doku

Background: Carbonated soft drinks consumption is associated with weight gain and other chronic diseases. Aim: To examine whether socio-demographic factors, health risk factors and psychological distress are associated with carbonated soft drink consumption among adolescents in selected senior high schools in Ghana. Methods: Data were obtained from the 2012 Ghana Global School-based Student Health Survey (GSHS). Participants consisted of 1756 school-going adolescents sampled using a two-stage cluster sampling method. Binomial logistic regression was used to determine whether socio-demographic factors, health risk factors and psychological distress were associated with consumption of soft drinks. Results: The prevalence of carbonated soft drinks consumption was 34.9%. Males (odds ratio (OR) = 0.73 (95% confidence intervals (CI) 0.59–0.92); p = 0.007), and participants with high socio-economic status (OR = 0.76 (95% CI 0.48–0.97); p = 0.033) had smaller odds for consumption of soft drinks. Also, adolescents in Senior High School (SHS) 3 (OR = 0.72 (95% CI 0.53–0.97); p = 0.034) and SHS 4 (OR = 0.63 (95% CI 0.43–0.91); p = 0.014) had smaller odds for soft drinks intake compared to those in SHS 1. Health risk factors associated with greater odds of high soft drink consumption were tobacco use (OR = 1.68, (95% CI 1.07–2.65); p = 0.025), fast food consumption (OR = 1.88, (95% CI 1.47–2.41); p = 0.011) and alcohol consumption (OR = 1.43, (95% CI 1.02–1.99); p = 0.039). Consuming adequate fruit (OR = 0.19 (95% CI 0.15–0.24); p = 0.000) and adequate vegetable (OR = 0.55 (95% CI 0.34–0.87); p = 0.011) were associated with lower odds for soft drink consumption. Adolescents who reported feeling anxious had smaller odds for soft drink intake (OR = 0.65, (95% CI 0.47–0.91); p = 0.011). Conclusions: The findings from this study show that socio-demographic characteristics, health risk factors and psychological distress are associated with the soft drink consumption among adolescents in Ghana. Interventions aimed at reducing soft drink consumption and other health risk factors are needed.


2021 ◽  
pp. 135910452199463
Author(s):  
Sara Moreno-Mansilla ◽  
Jorge J Ricarte ◽  
David J Hallford

Introduction: Cannabis is the most widely used psychoactive substance among adolescents worldwide, and the age at which consumption begins to decrease. Cannabis use in adolescents is associated with a wide range of adverse consequences in adulthood including increased vulnerability to psychosis and other mental disorders, as well as suicidal ideation and attempt. The aim of this study is to extend understanding of the link between cannabis use and mental illness by examining whether cannabis use at early ages predicts transdiagnostic variables that are precursors to severe clinical diagnoses. Methods: A descriptive cross-sectional study was conducted. The sample was made up of 605 adolescents from 7th to 9th grades, with a mean age of 13.2 years ( SD = 1.0, 47% girls). The variables evaluated were: anomalous perception of reality, intolerance of uncertainty, rumination, suicide attempt, hopelessness, and symptoms of depression and anxiety. The administration of the questionnaires was carried out in groups of 20 participants under the supervision of a researcher in a unique session of 1 hour. Results: Adolescent cannabis users scored higher on all variables assessed: anomalous perception of reality (Cohen’s d = .60), rumination ( d = .48), intolerance of uncertainty ( d = .11), suicidal attempt (affirmative answer: 25.9% of users vs 7.7% of non-users), hopelessness ( d = .85), symptoms of depression ( d = .80), and anxiety ( d = .39). A binary logistic regression showed that the only variable uniquely related to cannabis use was hopelessness (Wald = 4.560, OR: 1.159, p = .033). Conclusions: Among some mental health risk factors, hopelessness appears uniquely related to cannabis use. Adolescents may use cannabis as a coping strategy for negative thoughts and emotions, or it may be a consequence of cannabis use. Future prevention programs should focus on preventing/treating modifiable factors such as hopelessness, and delaying cannabis use in specific subgroups of adolescents who experience pathologies such as depression or suicide attempts.


2006 ◽  
Vol 18 (6) ◽  
pp. 304-305
Author(s):  
N Potts ◽  
D Wilson ◽  
A Taylor ◽  
T Gill ◽  
G Schrader ◽  
...  

2016 ◽  
Vol 74 (1) ◽  
pp. 14-23 ◽  
Author(s):  
Natalie V Schwatka ◽  
Adam Atherly ◽  
Miranda J Dally ◽  
Hai Fang ◽  
Claire vS Brockbank ◽  
...  

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