scholarly journals MultiP-SChlo: multi-label protein subchloroplast localization prediction with Chou’s pseudo amino acid composition and a novel multi-label classifier

2015 ◽  
Vol 31 (16) ◽  
pp. 2639-2645 ◽  
Author(s):  
Xiao Wang ◽  
Weiwei Zhang ◽  
Qiuwen Zhang ◽  
Guo-Zheng Li
Keyword(s):  
Amino Acid ◽  
Amino Acid Composition ◽  
Acid Composition ◽  
Pseudo Amino Acid Composition ◽  
Label Protein ◽  
Localization Prediction

scholarly journals Plant-mSubP: a computational framework for the prediction of single- and multi-target protein subcellular localization using integrated machine-learning approaches

AoB Plants ◽  
2019 ◽  
Vol 12 (3) ◽  
Author(s):  
Sitanshu S Sahu ◽  
Cristian D Loaiza ◽  
Rakesh Kaundal
Keyword(s):  
Machine Learning ◽  
Amino Acid ◽  
Subcellular Localization ◽  
Amino Acid Composition ◽  
Acid Composition ◽  
Learning Approaches ◽  
Pseudo Amino Acid Composition ◽  
Hybrid Features ◽  
Dual Label ◽  
Localization Prediction

Abstract The subcellular localization of proteins is very important for characterizing its function in a cell. Accurate prediction of the subcellular locations in computational paradigm has been an active area of interest. Most of the work has been focused on single localization prediction. Only few studies have discussed the multi-target localization, but have not achieved good accuracy so far; in plant sciences, very limited work has been done. Here we report the development of a novel tool Plant-mSubP, which is based on integrated machine learning approaches to efficiently predict the subcellular localizations in plant proteomes. The proposed approach predicts with high accuracy 11 single localizations and three dual locations of plant cell. Several hybrid features based on composition and physicochemical properties of a protein such as amino acid composition, pseudo amino acid composition, auto-correlation descriptors, quasi-sequence-order descriptors and hybrid features are used to represent the protein. The performance of the proposed method has been assessed through a training set as well as an independent test set. Using the hybrid feature of the pseudo amino acid composition, N-Center-C terminal amino acid composition and the dipeptide composition (PseAAC-NCC-DIPEP), an overall accuracy of 81.97 %, 84.75 % and 87.88 % is achieved on the training data set of proteins containing the single-label, single- and dual-label combined, and dual-label proteins, respectively. When tested on the independent data, an accuracy of 64.36 %, 64.84 % and 81.08 % is achieved on the single-label, single- and dual-label, and dual-label proteins, respectively. The prediction models have been implemented on a web server available at http://bioinfo.usu.edu/Plant-mSubP/. The results indicate that the proposed approach is comparable to the existing methods in single localization prediction and outperforms all other existing tools when compared for dual-label proteins. The prediction tool will be a useful resource for better annotation of various plant proteomes.

scholarly journals Prediction of Aptamer-Target Interacting Pairs with Pseudo-Amino Acid Composition

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86729 ◽  
Author(s):  
Bi-Qing Li ◽  
Yu-Chao Zhang ◽  
Guo-Hua Huang ◽  
Wei-Ren Cui ◽  
Ning Zhang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Composition ◽  
Acid Composition ◽  
Pseudo Amino Acid Composition
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