Testability of the Role of Natural Selection within Theories of Population Genetics and Evolution

1978 ◽  
Vol 29 (3) ◽  
pp. 223-242 ◽  
Author(s):  
GERHARD D. WASSERMANN
Keyword(s):  
Population Genetics ◽  
Natural Selection

Evolution: Medicine’s most basic science

2020 ◽  
pp. 39-42
Author(s):  
Randolph M. Nesse ◽  
Richard Dawkins
Keyword(s):  
Population Genetics ◽  
Natural Selection ◽  
Basic Science ◽  
Evolutionary Biology ◽  
Phylogenetic Trees ◽  
The Body ◽  
Clinical Implications ◽  
Trade Offs ◽  
The Cost

The role of evolutionary biology as a basic science for medicine is expanding rapidly. Some evolutionary methods are already widely applied in medicine, such as population genetics and methods for analysing phylogenetic trees. Newer applications come from seeking evolutionary as well as proximate explanations for disease. Traditional medical research is restricted to proximate studies of the body’s mechanism, but separate evolutionary explanations are needed for why natural selection has left many aspects of the body vulnerable to disease. There are six main possibilities: mismatch, infection, constraints, trade-offs, reproduction at the cost of health, and adaptive defences. Like other basic sciences, evolutionary biology has limited direct clinical implications, but it provides essential research methods, encourages asking new questions that foster a deeper understanding of disease, and provides a framework that organizes the facts of medicine.

Evo-devo: A New Evolutionary Paradigm?

2005 ◽  
Vol 56 ◽  
pp. 105-124
Author(s):  
Michael Ruse
Keyword(s):  
Population Genetics ◽  
Natural Selection ◽  
Newtonian Mechanics ◽  
Evo Devo ◽  
Morphogenetic Fields ◽  
Better Than

The homologies of process within morphogenetic fields provide some of the best evidence for evolution—just as skeletal and organ homologies did earlier. Thus, the evidence for evolution is better than ever. The role of natural selection in evolution, however, is seen to play less an important role. It is merely a filter for unsuccessful morphologies generated by development. Population genetics is destined to change if it is not to become as irrelevant to evolution as Newtonian mechanics is to contemporary physics. (Gilbert, Opitz, and Raff 1996, 368)

Evo-devo: A New Evolutionary Paradigm?

2005 ◽  
Vol 56 ◽  
pp. 8-9
Author(s):  
Michael Ruse
Keyword(s):  
Population Genetics ◽  
Natural Selection ◽  
Newtonian Mechanics ◽  
Evo Devo ◽  
Morphogenetic Fields ◽  
Better Than

The homologies of process within morphogenetic fields provide some of the best evidence for evolution—just as skeletal and organ homologies did earlier. Thus, the evidence for evolution is better than ever. The role of natural selection in evolution, how–ever, is seen to play less an important role. It is merely a filter for unsuccessful morphologies generated by development. Population genetics is destined to change if it is not to become as irrelevant to evolution as Newtonian mechanics is to contempo–rary physics. (Gilbert, Opitz, and Raff 1996, 368)

Randomness and Complexity

2018 ◽  
Author(s):  
Steven E. Vigdor
Keyword(s):  
Quantum Mechanics ◽  
Natural Selection ◽  
Rna World ◽  
Biological Evolution ◽  
Variable Theory ◽  
Cosmological Natural Selection ◽  
Einstein Podolsky Rosen ◽  
World Hypothesis ◽  
Rna World Hypothesis

Chapter 7 describes the fundamental role of randomness in quantum mechanics, in generating the first biomolecules, and in biological evolution. Experiments testing the Einstein–Podolsky–Rosen paradox have demonstrated, via Bell’s inequalities, that no local hidden variable theory can provide a viable alternative to quantum mechanics, with its fundamental randomness built in. Randomness presumably plays an equally important role in the chemical assembly of a wide array of polymer molecules to be sampled for their ability to store genetic information and self-replicate, fueling the sort of abiogenesis assumed in the RNA world hypothesis of life’s beginnings. Evidence for random mutations in biological evolution, microevolution of both bacteria and antibodies and macroevolution of the species, is briefly reviewed. The importance of natural selection in guiding the adaptation of species to changing environments is emphasized. A speculative role of cosmological natural selection for black-hole fecundity in the evolution of universes is discussed.

scholarly journals The role of historical factors and natural selection in the evolution of breeding systems of Oxalis alpina in the Sonoran desert ‘Sky Islands’

2010 ◽  
Vol 23 (10) ◽  
pp. 2163-2175 ◽  
Author(s):  
J. PÉREZ-ALQUICIRA ◽  
F. E. MOLINA-FREANER ◽  
D. PIÑERO ◽  
S. G. WELLER ◽  
E. MARTÍNEZ-MEYER ◽  
...  
Keyword(s):  
Natural Selection ◽  
Sonoran Desert ◽  
Breeding Systems ◽  
Sky Islands ◽  
Historical Factors

Pregnancy as a Factor of Adaptive Human Evolution. The Role of Natural Selection in the Origin of Preeclampsia

2021 ◽  
Vol 57 (1) ◽  
pp. 23-35
Author(s):  
V. N. Serebrova ◽  
E. A. Trifonova ◽  
V. A. Stepanov
Keyword(s):  
Natural Selection ◽  
Human Evolution

scholarly journals Increasing variability of body mass and health correlates in Swiss conscripts, a possible role of relaxed natural selection?

2018 ◽  
Vol 2018 (1) ◽  
pp. 116-126 ◽  
Author(s):  
Kaspar Staub ◽  
Maciej Henneberg ◽  
Francesco M Galassi ◽  
Patrick Eppenberger ◽  
Martin Haeusler ◽  
...  
Keyword(s):  
Natural Selection ◽  
Body Mass

scholarly journals Intragenomic variation in mutation biases causes underestimation of selection on synonymous codon usage

2021 ◽  
Author(s):  
Alexander L Cope ◽  
Premal Shah
Keyword(s):  
Population Genetics ◽  
Natural Selection ◽  
Codon Usage ◽  
Codon Bias ◽  
Synonymous Codon ◽  
Synonymous Codon Usage ◽  
Mutation Bias ◽  
Biased Gene Conversion ◽  
Intragenomic Variation ◽  
The Impact

Patterns of non-uniform usage of synonymous codons (codon bias) varies across genes in an organism and across species from all domains of life. The bias in codon usage is due to a combination of both non-adaptive (e.g. mutation biases) and adaptive (e.g. natural selection for translation efficiency/accuracy) evolutionary forces. Most population genetics models quantify the effects of mutation bias and selection on shaping codon usage patterns assuming a uniform mutation bias across the genome. However, mutation biases can vary both along and across chromosomes due to processes such as biased gene conversion, potentially obfuscating signals of translational selection. Moreover, estimates of variation in genomic mutation biases are often lacking for non-model organisms. Here, we combine an unsupervised learning method with a population genetics model of synonymous codon bias evolution to assess the impact of intragenomic variation in mutation bias on the strength and direction of natural selection on synonymous codon usage across 49 Saccharomycotina budding yeasts. We find that in the absence of a priori information, unsupervised learning approaches can be used to identify regions evolving under different mutation biases. We find that the impact of intragenomic variation in mutation bias varies widely, even among closely-related species. We show that the overall strength and direction of selection on codon usage can be underestimated by failing to account for intragenomic variation in mutation biases. Interestingly, genes falling into clusters identified by machine learning are also often physically clustered across chromosomes, consistent with processes such as biased gene conversion. Our results indicate the need for more nuanced models of sequence evolution that systematically incorporate the effects of variable mutation biases on codon frequencies.

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