scholarly journals 392 Magseed-Guided Wide Local Excision During the COVID-19 Pandemic: A Tenable Solution to Barriers in Accessing Elective Breast Cancer Surgery

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
J J Teh ◽  
W Cai ◽  
M Kedrzycki ◽  
P T R Thiruchelvam ◽  
D S Elson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Local Excision ◽  
Wide Local Excision ◽  
Ductal Carcinoma ◽  
Patient Flow ◽  
University Hospital ◽  
Breast Cancer Surgery ◽  
Breast Cancers ◽  
Suitable Alternative ◽  
Patient Reported

Abstract Introduction Magseed-guided localisation has emerged as a suitable alternative to wire-guided localisation (WGL) for impalpable breast cancers, with advantages including advanced insertion and simpler logistical planning. Given the severe disruption to elective surgeries during the Covid-19 pandemic, a local Magseed pathway was developed enabling safe patient flow. Magseed was inserted well in advance of the operation, enabling time to self-isolate and obtain a negative COVID swab prior to admission to a dedicated COVID -free suite. We present the patient-reported outcomes of the new pathway. Method A prospective service evaluation was conducted in a University hospital. Patients undergoing Magseed-guided wide local excision (WLE) from 01/07/2020 to present were surveyed to detail their experiences on the Magseed pathway. Qualitative data investigating anxiety and comfort post-insertion were reported using 10-fold Likert scales. Quantitative data was collected on patient demographics and tumour specification. Results 41/46 women who underwent Magseed localisation WLE completed the survey, with median age 65 years (IQR 53-72) and median BMI 26.5 kg/m2 (IQR 22.4-30.8). 71% had invasive ductal carcinoma with or without ductal carcinoma in-situ. 10% women found the procedure uncomfortable (<5) and 98% women reported low anxiety (<5) over seed displacement. If given the choice, 98% patients would prefer Magseed over WGL. Conclusions The new Magseed pathway is regarded positively among patients, despite ongoing disruption in elective breast cancer services. Given the progression of the second wave and likelihood of future outbreaks, Magseed localisation could be adopted widely to ensure continuous provision of safe elective surgeries.

Wire Guided Wide Local Excision of Clinically Undetectable Breast Cancer - Initial Experience in Bangladesh

2020 ◽  
Vol 23 (2) ◽  
pp. 81-86
Author(s):  
Samia Mubin ◽  
Jahangir Hussain ◽  
Syed Jamal Pervez ◽  
Biswajit Bhowmik ◽  
Saif Uddin Ahmed
Keyword(s):  
Breast Cancer ◽  
Local Excision ◽  
Wide Local Excision ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Surgical Oncology ◽  
Screening Mammography ◽  
Breast Cancers ◽  
Close Margin ◽  
Adequate Treatment

Background: With the rise of awareness of breast cancer and better screening mammography, there are increasing number of breast cancers detected before becoming clinically evident. These cancers are mostly treated by wide local excision under guidance of a wire which is put with mammogram and/or USG. In Bangladesh this procedure has never been done. We started it in Surgical Oncology Division in BSMMU with the collaboration of Department of Radiology. Methods: We have performed the procedure on 7 patients within 19 months. All of them had USG and mammography detected small lesions. The average size being 7.24mm. From needle biopsy 3 cases showed suspicious cytology, 4 had IDCC, and 1 had DCIS. Wire was put in all cases under USG guidance. Wire Guided Wide Local Excision was performed in all cases. $ patients underwent SLNB. Results: The age range was between 26 to 55 years with the average age of 43.86 years. 4 of them being post-menopausal. One case came benign. Other were malignant with clear margins. One case had close margin, which was later re-excised. All cases were sent for adjuvant therapy. Histopathology showed 4 patients of invasive ductal carcinoma, 1 patient each of invasive lobular carcinoma, DCIS and 1 being benign. Conclusion: This well-established procedure can be performed in Bangladesh to meet the goal of ensuring adequate treatment and cosmesis of the patients with impalpable cancer, amidst constrained facilities. Journal of Surgical Sciences (2019) Vol. 23(2): 81-86

Pathologic characteristics of breast cancer with special emphasis on prevalence of triple-negative breast cancer from Kenya: A 4-year experience.

2011 ◽  
Vol 29 (27_suppl) ◽  
pp. 35-35
Author(s):  
S. Sayed ◽  
Z. Moloo ◽  
S. Mukono ◽  
R. Wasike ◽  
R. R. Chauhan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Significant Proportion ◽  
Small Sample ◽  
University Hospital ◽  
Breast Cancers ◽  
Grade 3

35 Background: Previous sub classification of breast cancer in Kenya has been fraught by small sample size, non uniform staining methodology and lack of independent review. Triple Negative Breast Cancer (TNBC) is a “special interest” cancer since it represents a significant proportion of breast cancer patients and is associated with a poorer prognosis. We aimed to determine the estrogen receptor (ER), progesterone receptor (PR) and Her2/neu receptor characteristics of breast cancers and the prevalence of TNBC diagnosed at Aga Khan University Hospital, Nairobi (AKUHN) between 2007 to date. Methods: Slides and blocks of archived invasive breast cancers diagnosed at AKUHN were identified, retrieved and reviewed by two independent pathologists. Histological type, grade and pathological stage were documented. Representative sections from available blocks were stained for ER, PR, Her2 with appropriate internal controls. Scores for ER/PR were interpreted based on the ALLRED system, Her2 /neu scoring followed CAP guidelines. The initial 111 cases were validated and confirmed at Sunnybrook Health Sciences Centre, Toronto. Results: 456 cases of invasive breast cancers were diagnosed at AKUHN during the study period. 91% of cases were invasive ductal carcinomas (NOS).The rest were special types. 37% of the tumors were grade 3 and 63% were grade 2. Blocks for 318 of 456 cases were available for receptor analysis. 54% were ER and/or PR positive, with 52% of these in women < 50 yrs. 86% of the ER and/or PR positive tumors were grade 2. Only 12% were Her2/neu positive. Of the 318 cases studied, 111 (32%) were identified as TNBC. Median age was 53 yrs. 88% were grade 3. Conclusions: Invasive ductal carcinoma (NOS) was the most common breast cancer in our study. Nearly half of our cases were ER and/or PR positive and a third were TNBC. Both occurred predominantly in women less than 50 yrs. This represents the largest validated pathologic sub classification of breast cancer from a tertiary academic hospital in Kenya. Expansion of this study to encompass all breast cancers diagnosed in Kenya is underway.

scholarly journals Review of mastectomy in the department of gynecology at the Treichville teaching hospital, Abidjan-Cote d’Ivoire

2018 ◽  
Vol 7 (4) ◽  
pp. 1313
Author(s):  
Yao Ignace N’guessan ◽  
Dia Jean-Marc Lamine ◽  
Toure Moctar ◽  
Saki Téa Corneille ◽  
Tela Simo Gilbert ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Axillary Dissection ◽  
Ductal Carcinoma ◽  
Sub Saharan Africa ◽  
University Hospital ◽  
Breast Cancer Surgery ◽  
Breast Cancer Patients ◽  
Simple Mastectomy ◽  
Sub Saharan ◽  
The University

Background: Mastectomy plays a key role in the management of breast cancer in our regions of sub-Saharan Africa. Because the advanced forms represent the essential stages of the diagnosis and some therapeutic means remain unavailable. Objective of this study was to report the experience of the practice of mastectomy in the treatment of breast cancer in our service.Methods: This is a retrospective and prospective, descriptive study conducted from January 1, 2013 to May 31, 2017 (age 05) at the University Hospital of Treichville involving 56 breast cancer patients who had undergone a mastectomy.Results: The frequency of the mastectomy was 28.5% and the average age of our patients was 48 years old. The majority of patients had an average socio-economic level (66%). 85.6% of our cancers discovered at advanced stages (T3 and T4). Adenocarcinoma accounted for 96% and infiltrating ductal carcinoma 82% of adenocarcinoma.Patey mastectomy associated with axillary dissection was performed in 96.4% and simple mastectomy in 3.5%. The results of axillary dissection reported lymph node invasion in 38 patients; With an average number of lymph nodes taken from 6.1 and an average number of ganglia affected is 3. Neoadjuvant chemotherapy was administered in 96.4% and adjuvant chemotherapy in 91%. Radiotherapy was performed in 34%. Complications were dominated by lymphoceles in 34% of cases. The 5-year survival of patients operating in the service is 37.8%.Conclusions: Mastectomy is at the forefront of breast cancer surgery in our service. She is supervised by chemotherapy. Radiotherapy remains inaccessible for most patients. Early detection would lead to conservative treatment and a reduction in the postoperative complication rate.

EVALUATION OF DUAL-SPECTRUM IR SPECTROGRAM SYSTEM ON INVASIVE DUCTAL CARCINOMA (IDC) BREAST CANCER

2011 ◽  
Vol 23 (06) ◽  
pp. 427-433 ◽  
Author(s):  
Chia-Yen Lee ◽  
Ching-Cheng Chuang ◽  
Hsin-Yu Hsieh ◽  
Wan-Rou Lee ◽  
Ching-Yen Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Blind Source Separation ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Source Separation ◽  
University Hospital ◽  
Multiple Time ◽  
Breast Cancers ◽  
Separation Algorithm ◽  
Cross Sectional

Invasive Ductal Carcinoma (IDC) is one of the most frequently diagnosed breast cancers. IDC accounts for about 8 out of 10 of all invasive breast cancers. While early detection of breast cancer is essential for the reduction of death rate, there may be already more than 107 cells in a breast cancer when it can be observed by X-ray mammogram. In contrast, the passive IR spectrogram proposed by Szu et al. was shown to be promising in detecting breast cancers several months ahead of mammogram. With energy readings from two IR cameras, middle wavelength IR (MIR, 3–5 μm) and long wavelength IR (LIR, 8–12 μm), dual-spectrum IR (DS-IR) spectrogram may be computed by using the deterministic neighborhood-based blind source separation algorithm developed by Szu et al..4–7 To evaluate the performance of the DS-IR spectrogram on detection of IDC, a DS-IR spectrogram hardware system is built and a sub-pixel super-resolution registration is developed to implement the deterministic neighborhood-based blind source separation algorithm. Clinical tests have been carried out with the approval of Institutional Review Board of National Taiwan University Hospital. From August 2007 to June 2008, 35 patients aged between 30–66 (average age 49) with IDC breast cancers were recruited in this project. The results demonstrate that 62.86% of success rate for IDC detection may be achieved with the cross-sectional data. Longitudinal study shows that breast cancers may be detected more accurately by cross-referencing s1 maps of multiple time-points.

scholarly journals Recommendation and Acceptance of Counselling for Familial Cancer Risk in Newly Diagnosed Breast Cancer Cases

Breast Care ◽  
2021 ◽  
pp. 1-6
Author(s):  
Karin Kast ◽  
Julia Häfner ◽  
Evelin Schröck ◽  
Arne Jahn ◽  
Carmen Werner ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Risk ◽  
Genetic Counselling ◽  
Primary Breast Cancer ◽  
Ductal Carcinoma ◽  
Familial Cancer ◽  
University Hospital ◽  
Tumor Board ◽  
Newly Diagnosed ◽  
Familial Cancer Risk

<b><i>Background:</i></b> In clinical routine, not every patient who is offered genetic counselling and diagnostics in order to investigate a familial cancer risk predisposition opts for it. Little is known about acceptance of counselling and testing in newly diagnosed breast cancer cases in Germany. <b><i>Methods:</i></b> All primary breast cancer cases and patients with DCIS (ductal carcinoma in situ) treated at the University Hospital of Dresden between 2016 and 2019 were included. The number of tumor board recommendations for genetic counselling on the basis of the GC-HBOC risk criteria was recorded. Acceptance was analyzed by number of cases with counselling in the GC-HBOC-Center Dresden. <b><i>Results:</i></b> Of 996 primary breast cancer and DCIS cases, 262 (26.3%) were eligible for genetic counselling. Recommendation for genetic counselling was accepted by 64.1% (168/262). Of these 90.5% (152/168) opted for molecular genetic analysis. The acceptance rate for counselling increased between 2016 and 2019 from 58.3 to 72.6%. Altogether, 20.4% (31/152) patients were found to carry a pathogenic variant in the breast cancer genes <i>BRCA1</i> or <i>BRCA2</i>. <b><i>Conclusion:</i></b> Acceptance of recommendation is increasing as clinical consequences augment. Optimization in providing information about hereditary cancer risk and in accessibility of counselling and testing is required to further improve acceptance of recommendation.

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