scholarly journals 653 Adverse Effects of Isosulfan Blue Dye in Sentinel Lymph Node Mapping in Breast Cancer: A meta-analysis

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
A Yoong ◽  
D Fanelli ◽  
P Pratheepan ◽  
A Das ◽  
J Agilinko
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Adverse Effects ◽  
Reaction Rate ◽  
Meta Analysis ◽  
Sentinel Lymph Node Mapping ◽  
Blue Dye ◽  
Isosulfan Blue ◽  
Lymph Node Mapping ◽  
Isosulfan Blue Dye

Abstract Aim The aim of the study is to investigate the available evidence on the adverse effects of the use of isosulfan blue dye in sentinel lymph node mapping in breast cancer patients and to determine the treatment modalities for such complications. Method We carried out a thorough search of relevant articles in PubMed, Medline and Embase databases using the PRISMA guideline. Studies reporting on the adverse effects of isosulfan blue dye were included. Adverse effects were subdivided into 3 groups: Grade I, Grade II and Grade III. Weighted means were extracted and evaluated for procedure adverse reactions. A meta-analysis of proportion was conducted using random-effect models to analyse adverse effects rates. Results Grade I reactions were seen in 184 patients, Grade II in 4 patients and 50 patients developed Grade III reactions. The total rate of adverse reactions was 1.10% [CI: 0.96 to 1.26]; Grade I reaction rate was 0.82% [CI: 0.70 to 0.96], Grade II reaction rate was 0.02% [CI: 0.006 to 0.054] and Grade III reaction rate was 0.24% [CI = 0.18 to 0.32]. Conclusions Currently, there is no level 1 evidence (meta-analysis) in the literature on the use of isosulfan blue dye in sentinel lymph node mapping in breast cancer patients. In our study, despite the low adverse reaction rate of isosulfan use, clinicians should still be aware of such complications following administration to ensure prompt treatment.

Isosulfan Blue Dye Reactions During Sentinel Lymph Node Mapping for Breast Cancer

2002 ◽  
Vol 95 (2) ◽  
pp. 385-388 ◽  
Author(s):  
Leslie L. Montgomery ◽  
Alisa C. Thorne ◽  
Kimberly J. Van Zee ◽  
Jane Fey ◽  
Alexandra S. Heerdt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Mapping ◽  
Blue Dye ◽  
Isosulfan Blue ◽  
Lymph Node Mapping ◽  
Isosulfan Blue Dye

Isosulfan Blue Dye Reactions During Sentinel Lymph Node Mapping for Breast Cancer

2002 ◽  
Vol 95 (2) ◽  
pp. 385-388
Author(s):  
Leslie L. Montgomery ◽  
Alisa C. Thorne ◽  
Kimberly J. Van Zee ◽  
Jane Fey ◽  
Alexandra S. Heerdt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Mapping ◽  
Blue Dye ◽  
Isosulfan Blue ◽  
Lymph Node Mapping ◽  
Isosulfan Blue Dye

scholarly journals Rate of sentinel lymph node identification using isosulfan blue dye in breast cancer patients at Charoenkrung Pracharak Hospital, Thailand

2014 ◽  
Vol 8 (4) ◽  
pp. 517-524
Author(s):  
Kampol Ratchaworapong ◽  
Sarawut Thanawut ◽  
Sirisanpang Yodavudh ◽  
Suthat Chottanapund
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Cancer Patients ◽  
Primary Breast Tumor ◽  
Blue Dye ◽  
Axillary Lymph ◽  
Isosulfan Blue ◽  
Breast Cancer Patients ◽  
Isosulfan Blue Dye

Abstract Background: The sentinel lymph node (SLN) is the first lymph node to receive lymphatic drainage from a primary breast tumor. If the SLN contains no metastatic tumor, then it is unlikely other lymph nodes will contain breast cancer metastasis. When the SLN does contains metastasis, an axillary lymph node dissection (ALND) is recommended to further stage the axilla and to maintain locoregional control. SLNs can be identified by using a dye, radioisotope, or combined techniques. Objective: To determine the rate of SLN identification using isosulfan blue dye in breast cancer patients at Charoenkrung Pracharak Hospital, Thailand, and factors that affect it. Methods: This prospective study of 106 consecutive cases breast cancer enrolled 105 women (1 bilateral breast cancer case) between October 2011 and October 2013 at Charoenkrung Pracharak Hospital. Clinical and pathological features were analyzed for the effectiveness of SLN identification using isosulfan blue dye. Results: The rate of SLN identification using isosulfan blue dye in breast cancer patients at Charoenkrung Pracharak Hospital was 92%. The method was safe and well tolerated in early-stage breast cancer patients. Conclusion: The effectiveness of sentinel node identification using isosulfan blue dye in breast cancer patients at Charoenkrung Pracharak Hospital is consistent with that shown in studies from other countries.

scholarly journals Sentinel lymph node mapping in endometrial cancer: a systematic review and meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (28) ◽  
pp. 46601-46610 ◽  
Author(s):  
Hefeng Lin ◽  
Zheyuan Ding ◽  
Vishnu Goutham Kota ◽  
Xiaoming Zhang ◽  
Jianwei Zhou
Keyword(s):  
Systematic Review ◽  
Endometrial Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Meta Analysis ◽  
Sentinel Lymph Node Mapping ◽  
Lymph Node Mapping

Feasibility of sentinel lymph node mapping of the ovary: a systematic review

2019 ◽  
Vol 29 (7) ◽  
pp. 1209-1215 ◽  
Author(s):  
Federica Dell'Orto ◽  
Pim Laven ◽  
Martina Delle Marchette ◽  
Sandrina Lambrechts ◽  
Roy Kruitwagen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Indocyanine Green ◽  
Detection Rate ◽  
Sentinel Lymph Node Mapping ◽  
Blue Dye ◽  
Sentinel Lymph Node Detection ◽  
Lymph Node Mapping ◽  
Cancer Data

Pelvic and para-aortic lymphadenectomy is routinely performed in early ovarian cancer to define the stage of the disease. However, it may be associated with increased blood loss, operative time, and length of hospitalization. The sentinel lymph node technique has been shown to be safe and feasible in vulvar, uterine, and cervical cancer. Data detailing feasibility and outcomes of sentinel lymph node mapping in ovarian cancer are scarce.To summarize the studies evaluating the feasibility of sentinel lymph node detection from the ovary, examining the technique and detection rate.A systematic search of the literature was performed using PubMed and Embase from June 1991 to February 2019. Studies describing the sentinel lymph node technique and lymphatic drainage of the ovaries were incorporated in this review. Ten articles were selected, comprising a total of 145 patients. A variety of agents were used, but the primary markers were technetium-99m radiocolloid (Tc-99m), patent blue, or indocyanine green, and the most common injection site was the ovarian ligaments.The overall sentinel lymph node detection rate was 90.3%.We propose a standardized technique sentinel lymph node mapping in ovarian cancer, using indocyanine green, or Tc-99m and blue dye as alternative tracers, injected in both the suspensory and the infundibulopelvic ligament of the ovary.

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