scholarly journals Epigenetic therapy using the histone deacetylase inhibitor for increasing therapeutic gain in oral cancer: prevention of radiation-induced oral mucositis and inhibition of chemical-induced oral carcinogenesis

2009 ◽  
Vol 30 (8) ◽  
pp. 1387-1397 ◽  
Author(s):  
Y.-L. Chung ◽  
M.-Y. Lee ◽  
N. N.M. Pui
Keyword(s):  
Oral Cancer ◽  
Cancer Prevention ◽  
Histone Deacetylase ◽  
Oral Mucositis ◽  
Histone Deacetylase Inhibitor ◽  
Epigenetic Therapy ◽  
Oral Carcinogenesis ◽  
Deacetylase Inhibitor ◽  
Therapeutic Gain ◽  
Radiation Induced

scholarly journals Effects of histone deacetylase inhibitor FR901228 on the expression level of telomerase reverse transcriptase in oral cancer

2005 ◽  
Vol 56 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Jun Murakami ◽  
Jun-ichi Asaumi ◽  
Noriko Kawai ◽  
Hidetsugu Tsujigiwa ◽  
Yoshinobu Yanagi ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Reverse Transcriptase ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Expression Level ◽  
Telomerase Reverse Transcriptase ◽  
Deacetylase Inhibitor

scholarly journals Dietary Sulforaphane, a Histone Deacetylase Inhibitor for Cancer Prevention

2009 ◽  
Vol 139 (12) ◽  
pp. 2393-2396 ◽  
Author(s):  
Emily Ho ◽  
John D. Clarke ◽  
Roderick H. Dashwood
Keyword(s):  
Cancer Prevention ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Deacetylase Inhibitor

scholarly journals Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells

Blood ◽  
2009 ◽  
Vol 114 (13) ◽  
pp. 2733-2743 ◽  
Author(s):  
Warren Fiskus ◽  
Yongchao Wang ◽  
Arun Sreekumar ◽  
Kathleen M. Buckley ◽  
Huidong Shi ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Hox Genes ◽  
Severe Combined Immunodeficiency ◽  
Histone H3 ◽  
Histone Methyltransferase ◽  
Epigenetic Therapy ◽  
Core Proteins ◽  
Deacetylase Inhibitor ◽  
Induced Apoptosis

Abstract The polycomb repressive complex (PRC) 2 contains 3 core proteins, EZH2, SUZ12, and EED, in which the SET (suppressor of variegation–enhancer of zeste-trithorax) domain of EZH2 mediates the histone methyltransferase activity. This induces trimethylation of lysine 27 on histone H3, regulates the expression of HOX genes, and promotes proliferation and aggressiveness of neoplastic cells. In this study, we demonstrate that treatment with the S-adenosylhomocysteine hydrolase inhibitor 3-deazaneplanocin A (DZNep) depletes EZH2 levels, and inhibits trimethylation of lysine 27 on histone H3 in the cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells and in primary AML cells. DZNep treatment induced p16, p21, p27, and FBXO32 while depleting cyclin E and HOXA9 levels. Similar findings were observed after treatment with small interfering RNA to EZH2. In addition, DZNep treatment induced apoptosis in cultured and primary AML cells. Furthermore, compared with treatment with each agent alone, cotreatment with DZNep and the pan-histone deacetylase inhibitor panobinostat caused more depletion of EZH2, induced more apoptosis of AML, but not normal CD34+ bone marrow progenitor cells, and significantly improved survival of nonobese diabetic/severe combined immunodeficiency mice with HL-60 leukemia. These findings indicate that the combination of DZNep and panobinostat is effective and relatively selective epigenetic therapy against AML cells.

scholarly journals Enhanced Radiation-Induced Cell Killing and Prolongation of γH2AX Foci Expression by the Histone Deacetylase Inhibitor MS-275

2004 ◽  
Vol 64 (1) ◽  
pp. 316-321 ◽  
Author(s):  
Kevin Camphausen ◽  
William Burgan ◽  
Michael Cerra ◽  
Kelli A. Oswald ◽  
Jane B. Trepel ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Cell Killing ◽  
Γh2ax Foci ◽  
Deacetylase Inhibitor ◽  
Radiation Induced
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