scholarly journals Whole Blood Ionized Magnesium, a Novel Nutrition Biomarker for Magnesium Intake

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1856-1856
Author(s):  
Jiada Zhan ◽  
Taylor Wallace ◽  
Sarah Butts ◽  
Sisi Cao ◽  
Connie Weaver ◽  
...  
Keyword(s):  
Oral Dose ◽  
Whole Blood ◽  
Maximum Concentration ◽  
Serum Magnesium ◽  
The Body ◽  
Magnesium Concentration ◽  
Ionized Magnesium ◽  
Magnesium Intake ◽  
Serum Magnesium Concentration ◽  
Total Urine

Abstract Objectives Most studies used serum magnesium concentration and total urine magnesium as nutrition biomarkers of magnesium, but whether these biomarkers are sensitive to changes in dietary intake of magnesium is uncertain. Whole blood ionized magnesium (iMg2+) is the free bioactive form of magnesium in the body, and therefore it could be more sensitive to the changes in magnesium intake. Thus, we aimed to compare the responses of iMg2+, serum magnesium concentration, and total urine magnesium following an oral dose of magnesium. Methods Healthy adults participated in a randomized, single-blind, placebo-controlled crossover trial. They were randomly assigned to 300 mg of magnesium chloride (MgCl2, ReMag®) or placebo, taken with a low-magnesium breakfast after 8-hours of fasting. Timed blood and urine samples were obtained beginning 15-minutes before breakfast, and then at 0, 0.5, 1, 2, 4, 6, 8, and 24-hours timepoints following breakfast. Pharmacokinetic analyses included area under the curve (AUC), the maximum concentration (Cmax), and the time to maximum concentration (Tmax) for iMg2+, serum magnesium concentration, and total urine magnesium. Data were analyzed using paired t-test and Wilcoxon signed-rank test, and reported as mean ± standard deviation, or as median and range, depending on normality. Results Seventeen participants were included in the data analyses. Responses were observed following MgCl2 compared to placebo for iMg2+ (AUC = 1.51 ± 0.96 vs. 0.84 ± 0.82, and Cmax = 1.38 ± 0.13 vs. 1.32 ± 0.07, both P < 0.05). We saw no response following MgCl2 versus placebo for serum magnesium concentration (AUC = 27.00 [0, 172.93] vs. 14.55 [0, 91.18], and Cmax = 2.38 [1.97, 4.01] vs. 2.24 [1.98, 4.31]), and for total urine magnesium (AUC = 201.74 ± 161.63 vs. 139.30 ± 92.84, and Cmax = 26.12 [12.91, 88.63] vs. 24.38 [13.51, 81.51]), both P > 0.05. Conclusions The response of iMg2+ to a single oral dose of magnesium was more pronounced than the responses of serum magnesium concentration and total urine magnesium. Therefore, iMg2+ may be a more sensitive nutrition biomarker for magnesium intake. Funding Sources Funding for this study was provided through an unrestricted educational grant from Think Healthy Group Inc.

scholarly journals Daily Magnesium Intake and Serum Magnesium Concentration among Japanese People

2008 ◽  
Vol 18 (4) ◽  
pp. 151-159 ◽  
Author(s):  
Yoriko Akizawa ◽  
Sadayuki Koizumi ◽  
Yoshinori Itokawa ◽  
Toshiyuki Ojima ◽  
Yosikazu Nakamura ◽  
...  
Keyword(s):  
Serum Magnesium ◽  
Magnesium Concentration ◽  
Japanese People ◽  
Magnesium Intake ◽  
Serum Magnesium Concentration

The effect of hypermagnesaemia on serum immunoreactive calcitonin levels in normal human subjects

1987 ◽  
Vol 116 (2) ◽  
pp. 282-286
Author(s):  
Koyasu Suzuki ◽  
Norio Kono ◽  
Toshio Onishi ◽  
Seiichiro Tarui
Keyword(s):  
Serum Calcium ◽  
Whole Blood ◽  
Baseline Level ◽  
Human Subjects ◽  
Serum Magnesium ◽  
Serum Levels ◽  
Ionized Calcium ◽  
Magnesium Concentration ◽  
Serum Magnesium Concentration ◽  
Normal Human

Abstract. The effect of hypermagnesaemia on serum levels of immunoreactive calcitonin was studied in normal human subjects. After iv administration of magnesium sulphate over 120 min, the mean (± sem) serum magnesium concentration rose from the baseline level of 0.9 ± 0.1 to 2.6 ± 0.3 mmol/l (P < 0.01), and thereafter remained higher than the baseline level. The magnesium infusion caused a significant increase in serum immunoreactive calcitonin levels (P < 0.01). The rise in serum magnesium concentration was accompanied by a significant decrease in the concentrations of corrected serum calcium and whole blood ionized calcium (P < 0.01, P < 0.01, respectively). Our results suggest that hypermagnesaemia causes an increase in serum immunoreactive calcitonin levels in normal human subjects despite a decrease in the concentrations of corrected serum calcium and whole blood ionized calcium.

Maternal magnesium therapy, neonatal serum magnesium concentration and immediate neonatal outcomes

2017 ◽  
Vol 37 (12) ◽  
pp. 1297-1303 ◽  
Author(s):  
D Narasimhulu ◽  
A Brown ◽  
N M Egbert ◽  
M Rojas ◽  
S Haberman ◽  
...  
Keyword(s):  
Serum Magnesium ◽  
Neonatal Outcomes ◽  
Magnesium Concentration ◽  
Serum Magnesium Concentration ◽  
Magnesium Therapy

53: Serum Magnesium Concentration After Magnesium Citrate Bowel Preparation

2010 ◽  
Vol 55 (4) ◽  
pp. B45
Author(s):  
Nisha Bhatt ◽  
George Bayliss ◽  
M. Rachel Sim ◽  
Suzanne Martin ◽  
Jacqueline Wolf ◽  
...  
Keyword(s):  
Bowel Preparation ◽  
Serum Magnesium ◽  
Magnesium Concentration ◽  
Magnesium Citrate ◽  
Serum Magnesium Concentration

Total serum magnesium in cats with chronic kidney disease with nephrolithiasis

2019 ◽  
Vol 21 (12) ◽  
pp. 1172-1180 ◽  
Author(s):  
Fernanda Chicharo Chacar ◽  
Marcia Mery Kogika ◽  
Andréa C Ferreira ◽  
Khadine K Kanayama ◽  
Archivaldo Reche
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Magnesium ◽  
Magnesium Concentration ◽  
Total Serum ◽  
Serum Magnesium Concentration ◽  
Electrolyte Disturbances ◽  
Kaplan Meier ◽  
Ckd Stage ◽  
Stage 1

ObjectivesMagnesium has been ‘the forgotten ion’ for many years. Over the past decade, however, the role of magnesium in essential physiological functions and several illness conditions have been elucidated. Nevertheless, the investigation of magnesium in cats with chronic kidney disease (CKD) and nephrolithiasis is yet to be determined. The purpose of this study was to investigate whether CKD cats with nephrolithiasis have changes in total serum magnesium concentrations, and whether magnesium disorders may be associated with other electrolyte disturbances, as well as with prognosis. We also aimed to evaluate whether total serum magnesium concentration differs between CKD cats with and without nephrolithiasis.MethodsTotal serum magnesium concentrations were assessed in 42 cats with CKD with stage 1–4 nephrolithiasis. The correlation between magnesium and other electrolytes, as well as Kaplan–Meier survival analysis, were performed. We also selected 14 control cats with CKD without nephrolithiasis age-matched with 14 cats with CKD with nephrolithiasis.ResultsHypermagnesemia was observed in 16/42 (38.1%) and hypomagnesemia in 6/42 (14.3%) cats. Serum magnesium abnormalities were observed in cats of all stages, and marked hypermagnesemia was noted in cats with stage 4 CKD with nephrolithiasis ( P <0.001). There was a negative correlation between total serum magnesium and ionized calcium ( r = −0.64; P <0.01), and a positive correlation between total serum magnesium and serum phosphorus ( r = 0.58, P = 0.01). Cats with CKD with nephrolithiasis and hypomagnesemia or hypermagnesemia had higher mortality than those with normal total serum magnesium concentration ( P <0.01), regardless of CKD stage. There was no difference in total serum magnesium concentration between CKD cats with and without nephrolithiasis.Conclusions and relevanceCats with CKD with nephrolithiasis have magnesium abnormalities. Hypomagnesemia and hypermagnesemia were associated with an increase in mortality, and thus total serum magnesium abnormalities may be used as prognostic factors in these cases.

scholarly journals Circulating Ionized Magnesium as a Measure of Supplement Bioavailability: Results from a Pilot Study for Randomized Clinical Trial

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1245 ◽  
Author(s):  
Jiada Zhan ◽  
Taylor C. Wallace ◽  
Sarah J. Butts ◽  
Sisi Cao ◽  
Velarie Ansu ◽  
...  
Keyword(s):  
Pilot Study ◽  
Whole Blood ◽  
Area Under The Curve ◽  
Oral Intake ◽  
Magnesium Content ◽  
Magnesium Concentration ◽  
Rank Test ◽  
Ionized Magnesium ◽  
Signed Rank Test ◽  
Total Magnesium

Oral supplementation may improve the dietary intake of magnesium, which has been identified as a shortfall nutrient. We conducted a pilot study to evaluate appropriate methods for assessing responses to the ingestion of oral magnesium supplements, including ionized magnesium in whole blood (iMg2+) concentration, serum total magnesium concentration, and total urinary magnesium content. In a single-blinded crossover study, 17 healthy adults were randomly assigned to consume 300 mg of magnesium from MgCl2 (ReMag®, a picosized magnesium formulation) or placebo, while having a low-magnesium breakfast. Blood and urine samples were obtained for the measurement of iMg2+, serum total magnesium, and total urine magnesium, during 24 h following the magnesium supplement or placebo dosing. Bioavailability was assessed using area-under-the-curve (AUC) as well as maximum (Cmax) and time-to-maximum (Tmax) concentration. Depending on normality, data were expressed as the mean ± standard deviation or median (range), and differences between responses to MgCl2 or placebo were measured using the paired t-test or Wilcoxon signed-rank test. Following MgCl2 administration versus placebo administration, we observed significantly greater increases in iMg2+ concentrations (AUC = 1.51 ± 0.96 vs. 0.84 ± 0.82 mg/dL•24h; Cmax = 1.38 ± 0.13 vs. 1.32 ± 0.07 mg/dL, respectively; both p < 0.05) but not in serum total magnesium (AUC = 27.00 [0, 172.93] vs. 14.55 [0, 91.18] mg/dL•24h; Cmax = 2.38 [1.97, 4.01] vs. 2.24 [1.98, 4.31] mg/dL) or in urinary magnesium (AUC = 201.74 ± 161.63 vs. 139.30 ± 92.84 mg•24h; Cmax = 26.12 [12.91, 88.63] vs. 24.38 [13.51, 81.51] mg/dL; p > 0.05). Whole blood iMg2+ may be a more sensitive measure of acute oral intake of magnesium compared to serum and urinary magnesium and may be preferred for assessing supplement bioavailability.

scholarly journals Serum Magnesium Concentration Is Inversely Associated with Albuminuria and Retinopathy among Patients with Diabetes

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Jun Lu ◽  
Yuying Gu ◽  
Meixiang Guo ◽  
Peihong Chen ◽  
Hongtao Wang ◽  
...  
Keyword(s):  
Microvascular Complications ◽  
Serum Magnesium ◽  
Multiple Logistic Regression Analysis ◽  
Albumin Excretion Rate ◽  
Normal Serum ◽  
Fundus Photography ◽  
Magnesium Concentration ◽  
Serum Magnesium Concentration ◽  
Patients With Diabetes ◽  
Diabetic Microvascular Complications

Aim. To investigate the association between serum magnesium levels and microvascular complications among patients with diabetes.Methods. Patients with diabetes were recruited between April 2012 and January 2015. All patients received an assay of serum magnesium concentration, were screened for 24 h albumin excretion rate, and underwent nonmydriatic fundus photography. Albuminuria and retinopathy were defined accordingly. A total of 3,100 patients with normal serum magnesium levels were included in this study.Results. Patients with albuminuria and/or retinopathy had lower levels of serum magnesium than patients without these complications (P<0.001). The prevalence of isolated albuminuria, isolated retinopathy, and combined albuminuria and retinopathy decreased as the concentration of serum magnesium increased. Multiple logistic regression analysis indicated that the odds ratio for isolated albuminuria, isolated retinopathy, and concomitant albuminuria and retinopathy decreased by approximately 20% for every 0.1 mmol/L increase in serum magnesium concentration.Conclusion. Serum magnesium levels were negatively associated with the risk of diabetic microvascular complications among patients with serum magnesium levels within the normal range.

Mononuclear blood cell magnesium content and serum magnesium concentration in critically ill hypomagnesemic patients after replacement therapy

Nutrition ◽  
1997 ◽  
Vol 13 (4) ◽  
pp. 303-308
Author(s):  
Gordon S. Sacks ◽  
Rex O. Brown ◽  
Roland N. Dickerson ◽  
Syamal Bhattacharya ◽  
Phuong-Dung Lee ◽  
...  
Keyword(s):  
Blood Cell ◽  
Replacement Therapy ◽  
Critically Ill ◽  
Serum Magnesium ◽  
Magnesium Content ◽  
Magnesium Concentration ◽  
Serum Magnesium Concentration
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