scholarly journals Leisure Time Physical Activity Is Associated with Substantial Reduction in Risk of Breast Cancer and Breast Cancer Subtypes in Nigerian Women (P16-007-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Galya Bigman ◽  
Sally Adebamowo ◽  
Clement Adebamowo ◽  
Owale Badejo ◽  
Elima Jedy-Agba ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Breast Cancer Subtypes ◽  
Luminal A ◽  
Nigerian Women ◽  
Cancer Subtypes ◽  
Physical Activity Recommendations ◽  
Activity Recommendations

Abstract Objectives To examine the association between leisure-time physical activity (LTPA) and breast cancer in Nigerian women. The hypothesis was that LTPA decreased breast cancer cases in Nigerian women. To examine the association between LTPA and estrogen receptor positive (ER+), triple negative breast cancer (TNBC+), Luminal A breast cancer in Nigerian women. The hypothesis was that LTPA decreased breast cancer subtypes in Nigerian women. Methods We enrolled 739 newly diagnosed primary invasive breast cancer and 739 age-matched controls in Nigeria from 01/2014 to 07/2016. This analysis is restricted to the 40% of cases for whom we have complete ER, TNBC, and Luminal-A data and their matched controls. We derived the average amount of time per week spent on LTPA over the past year using a modified Nurses’ Health Study II PA questionnaire. LTPA was calculated from the total metabolic equivalent (METs) assigned for each reported physical activity hour/week (i.e., walking, cycling, and dancing). We examined LTPA by comparing participants who attained the WHO physical activity recommendations of at least 150 minutes of moderate-intensity or/and 75 minutes of vigorous-intensity aerobic activity weekly with those who did not. We used conditional logistic regression to estimate the adjusted Odds Ratio (OR) of LTPA and overall as well as subtypes of breast cancer. Results The mean (SD) age of cases was 41.6 (9.1) and controls 43.9 (11.8) years. Women who attained the WHO physical activity recommendations had 43% decreased the risk of breast cancer (OR = 0.57, 95% CI:0.42–0.77) compared with those who did not, after controlling for demographic, anthropometric and fertility-related factors. LTPA was also associated with reduced risk of breast cancer subtypes by 41% for ER+, 59% for TNBC+and 59% for Luminal A. Conclusions Physical activity is associated with reduced risk of breast cancer overall and by subtypes in Nigerian women. Funding Sources Training Program in Nigeria for Non-Communicable Diseases Research (TRAPING NCD) grant number FIC/NIH D43TW009106 from the Fogarty International Centre. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Fogarty International Centre or the National Institutes of Health.

Association of leisure time physical activity with breast cancer risk and breast cancer sub-types in Nigerian women.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e13085-e13085
Author(s):  
Galya Bigman ◽  
Sally Nneoma Adebamowo ◽  
Elima Enaji Jedy-Agba ◽  
Izuchukwu Benerdin Achusi ◽  
Clement Adebayo Adebamowo
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Moderate Intensity ◽  
Luminal A ◽  
Nigerian Women ◽  
Physical Activity Recommendations ◽  
Reduced Risk ◽  
Activity Recommendations

e13085 Background: The association between physical activity and breast cancer has not been studied among Nigerian women and in particular by breast cancer sub-types. Therefore are studies aims are to examine the association between leisure time physical activity (LTPA) and breast cancer in Nigerian women and to examine the association between LTPA and estrogen receptor positive (ER+), triple negative breast cancer (TNBC+), Luminal A breast cancer in Nigerian women. Methods: We enrolled 739 newly diagnosed primary invasive breast cancer and 739 age-matched controls in Nigeria from 01/2014 to 07/2016. This analysis is restricted to the 40% of cases for whom we have complete ER, TNBC and Luminal-A data and their matched controls. We derived the average amount of time per week spent on LTPA over the past one year using a modified Nurses’ Health Study II PA questionnaire. LTPA was calculated from the total metabolic equivalent (METs) assigned for each reported physical activity hour/week (i.e. walking, cycling, and dancing). We examined LTPA by comparing participants who attained the WHO physical activity recommendations of at least 150 minutes of moderate-intensity or/and 75 minutes of vigorous-intensity aerobic activity weekly with those who did not. We used conditional logistic regression to estimate the adjusted Odds Ratio (OR) of LTPA and overall as well as subtypes of breast cancer. Results: The mean (SD) age of cases was 41.6 (9.1) and controls was 43.9 (11.8) years. Women who attained the WHO physical activity recommendations had 43% decreased risk of breast cancer (OR = 0.57 95% CI:0.42-0.77) compared with those who did not, after controlling for demographic, anthropometric and fertility related factors. LTPA was also associated with reduced risk of breast cancer subtypes by 41% for ER+, 59% for TNBC+ and 59% for Luminal A. Conclusions: Physical activity is associated with reduced risk of breast cancer overall and by subtypes in Nigerian women.

scholarly journals Leisure-time physical activity among older adults in Brazil: results from the Brazilian National Health Survey – 2013

2021 ◽  
Author(s):  
Vítor Häfele ◽  
César Augusto Häfele ◽  
Jeferson Santos Jerônimo ◽  
Rodrigo Wiltgen Ferreira ◽  
Steve Anthony Maravillo ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
National Health ◽  
Health Survey ◽  
Leisure Time ◽  
Healthy Aging ◽  
Leisure Time Physical Activity ◽  
National Health Survey ◽  
Physical Activity Recommendations ◽  
Activity Recommendations

Introduction: Health behaviors are fundamental for healthy aging. In this sense, the practice of physical activity is one of the most beneficial factors for the health of individuals. Objective: To describe the prevalence of leisure-time physical activity among the older adults and analyze in terms of sociodemographic characteristics, national regions, Federative Units of Brazil, and types of physical activity practiced. Methods: Study utilizing data from the Brazilian National Health Survey - 2013. Leisure-time physical activity was analyzed with two distinct cutoff points: 1) Some physical activity - 10 or more minutes/week; 2) Meeting recommended 150 minutes/week of physical activity. Results: Nearly 21% of the older adults completed some physical activity, and 13.2% reached the physical activity recommendations. There was no difference in the prevalence of physical activity between men and women. Individuals aged 60-69 years and those with higher income were more active than their peers. As for the national regions, the North had the lowest prevalence of physically active older adults. Among all regions, walking was the most frequent form of physical activity practiced. Conclusion: The prevalence of older adults who practiced some physical activity and reached the physical activity recommendations was low, with walking being the most common form of physical activity. Older adults with higher age, low socioeconomic status and from the Northern Brazilian regions were the least active.

scholarly journals Physical Activity and Its Related Factors during the First COVID-19 Lockdown in Germany

2021 ◽  
Vol 13 (10) ◽  
pp. 5711
Author(s):  
Eszter Füzéki ◽  
Jan Schröder ◽  
David A. Groneberg ◽  
Winfried Banzer
Keyword(s):  
Physical Activity ◽  
Regression Analysis ◽  
Fixed Effects ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Binary Logistic Regression Analysis ◽  
Paired Data ◽  
Muscle Strengthening ◽  
Physical Activity Recommendations ◽  
Activity Recommendations

Lockdown measures including the closure of physical activity facilities were installed against the spread of the novel coronavirus in March 2020. The aim of the current online survey was to assess the lockdown effects on physical activity in German adults. We assessed physical activity using the European Health Interview Survey (EHIS) questionnaire. Pre-lockdown vs. lockdown differences were tested with the Χ2 test and the Student’s t-test for paired data. Predictor variables to explain compliance with physical activity recommendations were identified using a fixed effects binary logistic regression analysis. Data of 979 respondents were analyzed. Transport related and leisure time physical activity decreased (p < 0.001, d = 0.16; p < 0.001, d = 0.22, respectively). Compliance with physical activity recommendations decreased from 38.1% to 30.4% (chi2 [1, 1958] = 12.754, p < 0.001, V = 0.08). In the regression analysis, BMI (OR 0.944, 95% CI 0.909–0.981; p = 0.003), education (OR 1.111, 95% CI 1.021–1.208; p = 0.015), transport related (OR 1.000, 95% CI 1.000–1.000; p = 0.008) and leisure time physical activity (OR 1.004, 95% CI 1.003–1.004; p < 0.001), muscle strengthening (OR 5.206, 95% CI 4.433–6.114; p < 0.001), as well as the ‘lockdown vs. normal’ categorical variable (OR 0.583, 95% CI 0.424–0.802; p = 0.001) showed a contribution, while sex (p = 0.152), age (p = 0.266), work related physical activity (p = 0.133), and remote working (p = 0.684) did not. Physical activity declined in German adults, and should also be promoted in light of the emerging evidence on its protective effects of against COVID-19. Special attention should be given to muscle strengthening activities and groups with lower educational attainment.

Leisure-Time Walking and Compliance With ACSM/AHA Aerobic-Related Physical Activity Recommendations: 1999–2004 NHANES

2009 ◽  
Vol 6 (4) ◽  
pp. 393-402 ◽  
Author(s):  
Eugene C. Fitzhugh ◽  
Dixie L. Thompson
Keyword(s):  
Physical Activity ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Walking Behavior ◽  
Active Subject ◽  
Physical Activity Recommendations ◽  
The U.S ◽  
Activity Recommendations

Background:Adults integrate walking into their leisure-time (LT) in a variety of ways, including the use of walking as their only outlet for leisure-time physical activity (LTPA). The purpose of this study was to examine how LT walking relates to compliance with the 2007 ACSM/AHA guidelines for aerobic-related physical activity (PA).Methods:The study sample (N = 14,470 adults, 20+ years of age) came from the 1999 to 2004 NHANES. PA Interviews (past month) allowed each LT active subject to be classified by walking behavior (LTPA Active-No Walking, Walking-Only, Walking-Plus other LTPA). Walking prevalence, frequency (bouts per week), duration (minutes per bout), and compliance with ACSM/AHA recommendations were examined in SUDAAN.Results:Overall, 34.4% of adults in the U.S. walk in their LT. Among these active LT walkers, 34.8% were Walking-Only and 65.2% were Walking-Plus adults. Related to compliance with PA recommendations, Walking-Only (29.4%; 95% CI = 26.3 to 32.5) adults were significantly less likely than Walking-Plus (74.6%; 95% CI = 72.6 to 76.7) adults to be compliant with guidelines. The frequency of LTPA explains this difference in compliance (3.4 vs. 7.6 bouts/week, respectively).Conclusions:Walking-Only adults should be targeted for increased compliance with PA recommendations by promoting walking frequency and added variety among LTPAs.

Compliance with leisure-time physical activity recommendations in pregnant women

2011 ◽  
pp. no-no ◽  
Author(s):  
CARMEN AMEZCUA-PRIETO ◽  
PABLO LARDELLI-CLARET ◽  
ROCÍO OLMEDO-REQUENA ◽  
JUAN MOZAS-MORENO ◽  
AURORA BUENO-CAVANILLAS ◽  
...  
Keyword(s):  
Physical Activity ◽  
Pregnant Women ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Physical Activity Recommendations ◽  
Activity Recommendations

Occupational and leisure time physical activity and the risk of breast cancer

1999 ◽  
Vol 35 (5) ◽  
pp. 775-778 ◽  
Author(s):  
F Levi ◽  
C Pasche ◽  
F Lucchini ◽  
C La Vecchia
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Leisure Time ◽  
Leisure Time Physical Activity

scholarly journals Questionnaire survey assessing the leisure-time physical activity of hospital doctors and awareness of UK physical activity recommendations

2019 ◽  
Vol 5 (1) ◽  
pp. e000534 ◽  
Author(s):  
Jennifer A Cuthill ◽  
Martin Shaw
Keyword(s):  
Physical Activity ◽  
Leisure Time Physical Activity ◽  
Teaching Hospitals ◽  
Muscle Strengthening ◽  
Scottish Population ◽  
Physical Activity Recommendations ◽  
Hospital Doctors ◽  
Type Of Exercise ◽  
The Uk ◽  
Activity Recommendations

ObjectiveThe UK Government Physical Activity Recommendations suggest that adults should aim for 150 min of physical activity each week to maintain health. We assessed the total volume, frequency, intensity and type of exercise taken by hospital doctors in association with their specialty, age and knowledge of the specific components of the recommendations.MethodsAn anonymous paper-based questionnaire was distributed to doctors working in the two largest teaching hospitals in Glasgow. 332 questionnaires were analysed with a response rate of 60.3%.Results239 (72%) doctors felt they exercised regularly with 212 (63.9%) meeting the recommended volume of cardiovascular activity, similar to an age and sex-matched cohort of the general Scottish population. Only 78 (23.5%) doctors achieved the recommended muscle-strengthening activities. 108 (35.5%) doctors were aware recommendations for activity existed but only 45 (13.6%) were able to state the recommended duration of activity per week. Doctors who were aware of the recommendations were more likely to personally achieve them (OR 1.802, 95% CI 1.104 to 2.941) although other additional factors may contribute.ConclusionAlthough this was a small study in two hospitals, our results suggest that hospital doctors are as active as the general public in the UK of a similar age. Eight years after implementation, knowledge of specific components of the current physical activity recommendations remains poor. Efforts to improve this prior to graduation, combined with improving confidence and competence in counselling practices and enhancing the opportunities for doctors to exercise, could translate into improved healthcare promotion.

Comprehensive immunohistochemical analysis of RET, BCAR1, and BCAR3 expression in patients with Luminal A and B breast cancer subtypes

2022 ◽  
Author(s):  
Ana Carolina Pavanelli ◽  
Flavia Rotea Mangone ◽  
Piriya Yoganathan ◽  
Simone Aparecida Bessa ◽  
Suely Nonogaki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Immunohistochemical Analysis ◽  
Breast Cancer Subtypes ◽  
Luminal A ◽  
Cancer Subtypes

scholarly journals Identification of key genes unique to the luminal A and basal-like breast cancer subtypes via bioinformatic analysis

2020 ◽  
Author(s):  
Rong Jia ◽  
Zhongxian Li ◽  
Wei Liang ◽  
Yucheng Ji ◽  
Yujie Weng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Differentially Expressed Genes ◽  
Survival Data ◽  
Breast Cancer Subtypes ◽  
Differentially Expressed ◽  
Expression Data ◽  
Luminal A ◽  
Cancer Subtypes ◽  
Protein Protein Interaction ◽  
Basal Like Breast Cancer

Abstract Background Breast cancer subtypes are statistically associated with prognosis. The search for markers of breast tumor heterogeneity and the development of precision medicine for patients are the current focuses of the field. Methods We used a bioinformatic approach to identify key disease-causing genes unique to the luminal A and basal-like subtypes of breast cancer. First, we retrieved gene expression data for luminal A breast cancer, basal-like breast cancer, and normal breast tissue samples from The Cancer Genome Atlas database. The differentially expressed genes unique to the 2 breast cancer subtypes were identified and subjected to Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. We constructed protein–protein interaction networks of the differentially expressed genes. Finally, we analyzed the key modules of the networks, which we combined with survival data to identify the unique cancer genes associated with each breast cancer subtype. Results We identified 1,114 differentially expressed genes in luminal A breast cancer and 1,042 differentially expressed genes in basal-like breast cancer, of which the subtypes shared 500. We observed 614 and 542 differentially expressed genes unique to luminal A and basal-like breast cancer, respectively. Through enrichment analyses, protein–protein interaction network analysis, and module mining, we identified 8 key differentially expressed genes unique to each subtype. Analysis of the gene expression data in the context of the survival data revealed that high expression of NMUR1 and NCAM1 in luminal A breast cancer statistically correlated with poor prognosis, whereas the low expression levels of CDC7 , KIF18A , STIL , and CKS2 in basal-like breast cancer statistically correlated with poor prognosis. Conclusions NMUR1 and NCAM1 are novel key disease-causing genes for luminal A breast cancer, and STIL is a novel key disease-causing gene for basal-like breast cancer. These genes are potential targets for clinical treatment.

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