Disease Burden of Invasive Meningococcal Disease in the Netherlands Between June 1999 and June 2011: A Subjective Role for Serogroup and Clonal Complex

2015 ◽  
Vol 61 (8) ◽  
pp. 1281-1292 ◽  
Author(s):  
Susanne P. Stoof ◽  
Gerwin D. Rodenburg ◽  
Mirjam J. Knol ◽  
Lidewij W. Rümke ◽  
Sandra Bovenkerk ◽  
...  
Keyword(s):  
The Netherlands ◽  
Meningococcal Disease ◽  
Disease Burden ◽  
Clonal Complex ◽  
Invasive Meningococcal Disease

scholarly journals Implementation of MenACWY vaccination because of ongoing increase in serogroup W invasive meningococcal disease, the Netherlands, 2018

2018 ◽  
Vol 23 (16) ◽  
Author(s):  
Mirjam J Knol ◽  
Wilhelmina LM Ruijs ◽  
Laura Antonise-Kamp ◽  
Hester E de Melker ◽  
Arie van der Ende
Keyword(s):  
The Netherlands ◽  
Incidence Rate ◽  
Meningococcal Disease ◽  
Case Fatality Rate ◽  
Clonal Complex ◽  
Case Fatality ◽  
Annual Incidence ◽  
Invasive Meningococcal Disease ◽  
Fatality Rate ◽  
Annual Incidence Rate

The annual incidence rate of serogroup W invasive meningococcal disease in the Netherlands increased from < 0.05/100,000 (n < 10) before 2015 to 0.5/100,000 (n = 80) in 2017. Most isolates (94%) belong to clonal complex 11. The incidence rate is highest among  < 5 year-olds and 15–24 year-olds. The case fatality rate was 12% (17/138) in 2015–2017. From May 2018, MenACWY vaccination replaces MenC vaccination at age 14 months and from October 2018, 13–14 year-olds are offered MenACWY vaccination.

scholarly journals Characterization of Serogroup ANeisseria meningitidisfrom Invasive Meningococcal Disease Cases in Canada Between 1979 and 2006: Epidemiological Links to Returning Travellers

2008 ◽  
Vol 19 (3) ◽  
pp. 227-232 ◽  
Author(s):  
Angela M Sloan ◽  
Averil M Henderson ◽  
Raymond SW Tsang
Keyword(s):  
Meningococcal Disease ◽  
Clonal Complex ◽  
Disease Incidence ◽  
Developing Nations ◽  
Invasive Meningococcal Disease ◽  
Protein Antigens ◽  
Genes Encoding ◽  
Returning Travellers ◽  
The 1960S

INTRODUCTION: Serogroup ANeisseria meningitidishas repeatedly caused epidemics of invasive meningococcal disease (IMD) in developing nations since the 1960s. The present study is the first detailed study of serogroup A bacteria isolated in Canada.METHODS: Thirty-four serogroup A meningococcal isolates collected from individuals with IMD in Canada between 1979 and 2006 were characterized by serology and multilocus sequence typing of seven housekeeping enzyme genes and genes encoding three outer membrane protein antigens.RESULTS: Isolates were assigned to either the sequence type (ST)-1 or the ST-5 clonal complex. Clones within the ST-1 complex were recovered between 1979 and 1992, while clones of the ST-5 complex were isolated between 1987 and 2006; respectively, they accounted for 70.6% and 29.4% of all isolates studied. Isolates of the ST-1 complex were characterized by serosubtype antigen P1.3 or P1.3,6 with PorB allele 60 (serotype 4) and FetA sequence F5-1, while isolates of the ST-5 complex were characterized by serosubtype antigen P1.9 with PorB allele 47 (also serotype 4) and FetA sequence F3-1.CONCLUSIONS: The Canadian serogroup A IMD isolates likely originated in travellers returning from hyperendemic or epidemic areas of the globe where serogroup A bacteria circulate. Although the Canadian cases of serogroup A IMD were caused by clones known to have caused epidemics in developing countries, disease incidence remained low in Canada.

scholarly journals Genome Sequence of a Neisseria meningitidis Capsule Null Locus Strain from the Clonal Complex of Sequence Type 198

2012 ◽  
Vol 194 (18) ◽  
pp. 5144-5145 ◽  
Author(s):  
Sabine Schork ◽  
Andreas Schlüter ◽  
Jochen Blom ◽  
Susanne Schneiker-Bekel ◽  
Alfred Pühler ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Genome Sequence ◽  
Meningococcal Disease ◽  
Clonal Complex ◽  
Sequence Type ◽  
Invasive Meningococcal Disease ◽  
Content Type ◽  
Polysaccharide Capsules

ABSTRACTNeisseria meningitidisis a commensal and accidental pathogen exclusively of humans. Although the production of polysaccharide capsules is considered to be essential for meningococcal virulence, there have been reports of constitutively unencapsulated strains causing invasive meningococcal disease (IMD). Here we report the genome sequence of a capsule null locus (cnl) strain of sequence type 198 (ST-198), which is found in half of the reported cases of IMD caused bycnlmeningococcal strains.

Epidemiology of invasive meningococcal disease in the Netherlands, 1960–2012: an analysis of national surveillance data

2014 ◽  
Vol 14 (9) ◽  
pp. 805-812 ◽  
Author(s):  
Merijn W Bijlsma ◽  
Vincent Bekker ◽  
Matthijs C Brouwer ◽  
Lodewijk Spanjaard ◽  
Diederik van de Beek ◽  
...  
Keyword(s):  
The Netherlands ◽  
Meningococcal Disease ◽  
Surveillance Data ◽  
Invasive Meningococcal Disease ◽  
National Surveillance

scholarly journals Community outbreak of serogroup B invasive meningococcal disease in Beaujolais, France, February to June 2016: from alert to targeted vaccination

2018 ◽  
Vol 23 (28) ◽  
Author(s):  
Alexandra Thabuis ◽  
Karim Tararbit ◽  
Muhamed-Kheir Taha ◽  
Dominique Dejour-Salamanca ◽  
Vincent Ronin ◽  
...  
Keyword(s):  
Meningococcal Disease ◽  
Clonal Complex ◽  
Vaccination Campaign ◽  
Age Groups ◽  
Invasive Meningococcal Disease ◽  
Epidemic Threshold ◽  
Epidemic Area ◽  
Area North ◽  
Meningococcal Strain ◽  
Microbiological Surveillance

In February and March 2016, four cases of serogroup B invasive meningococcal disease (IMD) occurred over 3 weeks in a small area north of Lyon in the Auvergne-Rhône-Alpes region, France. There were no deaths but two cases had sequelae. This community outbreak was caused by a rare meningococcal strain of the clonal complex ST-32, covered by the 4CMenB/Bexsero vaccine. The incidence rate for serogroup B IMD in this area was 22.5 per 100,000 inhabitants, which is above the epidemic threshold (10/100,000). The number of cases observed was significantly higher than expected in the age group of 0–24 year-olds (standardised incidence ratio: 96). These results suggested the potential emergence of this invasive strain in this sub-population. In accordance with French recommendations, it was decided to vaccinate the population aged between 2 months and 24 years, living, working or studying in the epidemic area. The vaccination campaign took place from April to September 2016. Vaccination coverage was estimated at 47% for one dose and 40% for two doses. The lowest coverage estimations were observed for the age groups younger than 3 and 15–19 years. Enhanced epidemiological and microbiological surveillance reported a fifth case in June 2016, outside the epidemic area.

scholarly journals The Clinical Picture and Severity of Invasive Meningococcal Disease Serogroup W Compared With Other Serogroups in the Netherlands, 2015–2018

2019 ◽  
Vol 70 (10) ◽  
pp. 2036-2044 ◽  
Author(s):  
Anna D Loenenbach ◽  
Arie van der Ende ◽  
Hester E de Melker ◽  
Elisabeth A M Sanders ◽  
Mirjam J Knol
Keyword(s):  
The Netherlands ◽  
Meningococcal Disease ◽  
Clinical Picture ◽  
Disease Onset ◽  
Clinical Manifestations ◽  
Case Fatality ◽  
Invasive Meningococcal Disease ◽  
Almost All ◽  
Specific Symptoms ◽  
Host Characteristics

Abstract Background An increase in invasive meningococcal disease (IMD) serogroup W (IMD-W) cases caused by sequence type-11 clonal complex (cc11) was observed from October 2015 in the Netherlands. We compared the clinical picture and disease outcome of IMD-W cases with other serogroups, adjusting for host characteristics. Methods We included IMD cases reported from January 2015 to June 2018 in the Netherlands and assessed clinical manifestation and symptoms at disease onset and calculated case fatality rates (CFRs). We used logistic regression to compare clinical manifestations and mortality of IMD-W with IMD caused by meningococci serogroup B, Y, or C, adjusting for age, gender, and comorbidities. Results A total of 565 IMD cases were reported, of which 204 were IMD-W, 270 IMD-B, 63 IMD-Y, and 26 IMD-C. Most IMD-W isolates belonged to cc11 (93%; 175/188). Compared with other serogroups, IMD-W patients were diagnosed more often with septicemia (46%) or pneumonia (12%) and less often with meningitis (17%, P &lt; .001). IMD-W cases presented more often with respiratory symptoms (45%, P &lt; .001); 16% of IMD-W patients presented with diarrhea without IMD-specific symptoms (P = .061). The CFR for IMD-W was 16% (32/199, P &lt; .001). The differences between IMD-W and other serogroups remained after adjusting for age, gender, and comorbidities. Conclusions The atypical presentation and severe outcome among IMD-W cases could not be explained by age, gender, and comorbidities. Almost all our IMD-W cases were caused by cc11. More research is needed to identify the bacterial factors involved in clinical presentation and severity of IMD-W cc11.

Predicted coverage by 4CMenB vaccine against invasive meningococcal disease cases in the Netherlands

Vaccine ◽  
2020 ◽  
Vol 38 (49) ◽  
pp. 7850-7857
Author(s):  
W. Freudenburg-de Graaf ◽  
M.J. Knol ◽  
A. van der Ende
Keyword(s):  
The Netherlands ◽  
Meningococcal Disease ◽  
Invasive Meningococcal Disease ◽  
4Cmenb Vaccine

scholarly journals Evaluation of the surveillance system for invasive meningococcal disease (IMD) in the Netherlands, 2004 – 2016

2019 ◽  
Author(s):  
Diederik A.H. Brandwagt ◽  
Arie van der Ende ◽  
Helma (W.) L.M. Ruijs ◽  
Hester E. de Melker ◽  
Mirjam J. Knol
Keyword(s):  
Public Health ◽  
The Netherlands ◽  
Meningococcal Disease ◽  
Surveillance System ◽  
National Level ◽  
Vaccination Status ◽  
Invasive Meningococcal Disease ◽  
Reference Laboratory ◽  
Public Health Response ◽  
Notification Data

Abstract Background Enhanced surveillance for confirmed cases of invasive meningococcal disease (IMD) was introduced in the Netherlands in 2003, in which reference laboratory data (NRLBM) are linked with notification data (OSIRIS). The quality of surveillance information is important for public health decision making. Our objective was to describe the system and evaluate it for data completeness and timeliness.
Methods
Cases reported in the surveillance system from 2004 to 2016 were included. For the notification data, we used information on serogroup, vaccination status, mortality, and country of infection as indicators for record completeness. Notification times to regional and national level were calculated using the reported dates available in the notification database. 
Results
A total of 2,123 cases were reported in the years 2004-2016, of which 1.968 (93%) were reported by the reference laboratory and 1.995 (94%) in the notification system. Of all cases, 1.840 cases (87%) were reported in both systems and could be linked. The serogroup was known in 86% of the notified cases, and was significantly higher (94%) in the years 2013-2016. Information on vaccination status, mortality and country of infection was available in 88%, 99% and 97% of notified cases, respectively. Regional notification of cases occurred within one working day for 86% of cases and 98% were notified nationally within three days. 
Conclusions
A well performing IMD surveillance system was demonstrated and serogroup completeness has improved over the years. Underlining the need for reporting to both the clinical and laboratory surveillance system remains important to further improve the overall performance in supporting public health response and vaccination policy.

scholarly journals Serogroup C invasive meningococcal disease among men who have sex with men and in gay-oriented social venues in the Paris region: July 2013 to December 2014

2015 ◽  
Vol 20 (3) ◽  
Author(s):  
L Aubert ◽  
M K Taha ◽  
N Boo ◽  
Y Le Strat ◽  
A E Deghmane ◽  
...  
Keyword(s):  
Public Health ◽  
Meningococcal Disease ◽  
Clonal Complex ◽  
Invasive Meningococcal Disease ◽  
Gay Community ◽  
Health Authorities ◽  
Public Health Authorities ◽  
Paris Region ◽  
Sex With Men

In November 2014, French public health authorities renewed the recommendation to target for vaccination against invasive meningococcal disease men who have sex with men (MSM) and all individuals ≥25 years attending social venues associated with the gay community. This policy was extended beyond the Paris region as a reaction to the continuing spread of serogroup C isolates belonging to a new lineage within clonal complex cc11 since the recommendation was first issued in July 2013.

Antigenic and genetic characterization of serogroup C meningococci isolated from invasive meningococcal disease cases in Canada from 1999 to 2003

2005 ◽  
Vol 51 (7) ◽  
pp. 523-530 ◽  
Author(s):  
Dennis K.S Law ◽  
Jan Stoltz ◽  
Averil M Henderson ◽  
Raymond S.W Tsang
Keyword(s):  
Membrane Protein ◽  
Key Words ◽  
Outer Membrane Protein ◽  
Meningococcal Disease ◽  
Clonal Complex ◽  
Genetic Characterization ◽  
Hot Spot ◽  
Invasive Meningococcal Disease ◽  
Vaccination Campaigns

Four hundred and forty-two serogroup C Neisseria meningitidis isolates from individual invasive meningococcal disease (IMD) patients in Canada during the period 1999 to 2003 were analyzed. The majority (84%) of the serogroup C meningococci were characterized by the serotype antigen 2a and belonged to the clonal complex of electrophoretic type ET-15. However, after more than a decade of endemic disease as well as a number of outbreaks and many vaccination campaigns, both genetic and antigenic variants of the serogroup C serotype 2a meningococci were noted. Such variants include strains characterized as C:2a:P1.5 and C:2a:P1.7,1 as well as a non-serotypeable phenotype due to a mutational hot spot on the serotype 2a PorB outer-membrane protein. Meningococci characterized by the antigen formula B:2a:P1.5,2 and B:2a:P1.7,1 have also been found, which suggests capsule switching. Besides the clonal group of ET-15/ET-37, small numbers of serogroup C isolates were found to belong to the clonal complexes of ST-8 (Cluster A4), ST-41/44 (Lineage 3), ST-35, and ST-269.Key words: serogroup C, meningococci, genetic, antigenic, variants.

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