scholarly journals Spatiotemporal trends and prognosis of end-stage renal disease patients with biopsy-proven immunoglobulin A nephropathy in France from 2010 to 2014

2020 ◽  
Author(s):  
Thomas Robert ◽  
Rodolphe Jantzen ◽  
Alexandra Cambier ◽  
Matthieu Jamme ◽  
Cecile Couchoud ◽  
...  

Abstract Background Although end-stage renal disease (ESRD) is frequently used as an outcome marker for primary immunoglobulin A nephropathy (IgAN), the clinical course after reaching ESRD is not well documented. This study examined patients’ characteristics and survival in ESRD-related biopsy-proven IgAN in France. Methods French Renal Epidemiology and Information Network Registry data from 2010 to 2014 were used to analyse patients’ survival and outcome in incident ESRD patients >16 years of age with biopsy-proven primary IgAN, in comparison with other primary and secondary glomerulonephritis (GN), adult polycystic kidney disease (ADPKD) or diabetes. Multivariable survival analysis was adjusted for age, sex, time on dialysis and comorbidities. Results Among 17 138 incident dialysis patients with ESRD, IgAN (242.8/10 000 dialysis initiation) represents the most common GN related to ESRD during 2010. IgAN patients were the youngest, and had the fewest comorbidities and the highest use of peritoneal dialysis (PD) (17%). In comparison with the haemodialysis group, hazard ratios for death were not different in the preemptive transplantation group [0.46, 95% confidence interval (CI) 0.17–1.28] and in the PD group (0.77, 95% CI 0.44–1.33). Mortality rates in IgAN patients with preemptive transplantation and in those receiving dialysis waiting for transplantation were 2.9% (95% CI 0.0–5.6) and 6.7% (95% CI 0.9–12.3). Mortality rates of ADPKD patients receiving dialysis waiting for transplantation were higher (18%, 95% CI 3.1–30.6). Conclusion IgAN has the best prognosis among primary and secondary GN. IgAN patients receiving dialysis waiting transplantation seem to have a more favourable prognosis than ADPKD patients, who usually comprise the reference population. The underlying reasons for the difference in access treatment modalities should be investigated to improve survival with respect to renal disease.

2017 ◽  
Vol 33 (6) ◽  
pp. 963-971 ◽  
Author(s):  
Shigeru Tanaka ◽  
Toshiharu Ninomiya ◽  
Ritsuko Katafuchi ◽  
Kosuke Masutani ◽  
Akihiro Tsuchimoto ◽  
...  

2020 ◽  
Vol 38 (5) ◽  
pp. 925-935
Author(s):  
Elisa Russo ◽  
Daniela Verzola ◽  
Gennaro Salvidio ◽  
Barbara Bonino ◽  
Daniela Picciotto ◽  
...  

2010 ◽  
Vol 31 (9) ◽  
pp. 1230-1249
Author(s):  
Emily F. Shortridge ◽  
Cara V. James

African Americans are disproportionately represented among patients with end-stage renal disease (ESRD). ESRD is managed with a strict routine that might include regular dialysis as well as dietary, fluid intake, and other lifestyle changes. In a disease such as this, with such disruptive treatment modalities, marriage, specifically, and its ties to well-being have the potential to significantly affect adherence to medical treatment and lifestyle recommendations as well as downstream health outcomes such as disease progression and mortality. The authors used data from the Dialysis Morbidity and Mortality Study, Wave 2, of the U.S. Renal Data System Database, a prospective study of 4,000 ESRD patients selected from a random sample of 25% U.S. dialysis facilities, to investigate these research questions. They found that married African American ESRD patients had marginally better outcomes on several clinical and psychosocial measures, which they hypothesize may be attributable to the instrumental and emotional support conferred by marriage.


1984 ◽  
Vol 13 (4) ◽  
pp. 327-343 ◽  
Author(s):  
Gerald M. Devins ◽  
Yitzchak M. Binik ◽  
Tom A. Hutchinson ◽  
David J. Hollomby ◽  
Paul E. Barré ◽  
...  

The emotional impact of the intrusiveness of illness and patients' reduced control over several aspects of life were examined in the context of end-stage renal disease. A sample of thirty-five hemodialysis, ten continuous ambulatory peritoneal dialysis (CAPD), and twenty-five posttransplant patients participated in a standardized interview in which a series of eight self-report measures of positive and negative mood, life happiness, self-esteem, depression, and somatic symptoms of distress were obtained. Attending staff also completed a depression rating scale for each participant. Data reduction via principal-components analysis yielded two factors, corresponding to negative and positive mood, and these were submitted to covariance analyses in which age, general nonrenal health, and defensiveness were controlled statistically. Patients' perceptions of increased intrusiveness, and their perceptions of limited control over eleven life dimensions, each correlated significantly and uniquely with increased negative and decreased positive mood, suggesting that each of these two factors contributes importantly and independently to patients' distress. An “objective” continuum of intrusiveness, constructed by ranking the various treatment modalities represented in the sample, also related significantly to positive (but not to negative) mood levels.


2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i328-i328
Author(s):  
Nicholas C Chesnaye ◽  
Franz Schaefer ◽  
Marjolein Bonthuis ◽  
Rebecca Holman ◽  
Sergey Baiko ◽  
...  

2017 ◽  
Vol 66 (4) ◽  
pp. 991-996 ◽  
Author(s):  
Nathan L. Liang ◽  
Theodore H. Yuo ◽  
Georges E. Al-Khoury ◽  
Eric S. Hager ◽  
Michel S. Makaroun ◽  
...  

Author(s):  
Sullivan John D

From the establishment of nearly universal health coverage for end stage renal disease in 1972 to 2021, the primary treatment modality has been in-center hemodialysis despite significant advances in home therapies such as peritoneal dialysis and home hemodialysis. There are many theories as to why peritoneal and home hemodialysis lack so far behind in prescriptions with profitability and or a patient’s compliance or support leading the logical explanations. But 2020 was a different year with the surge in COVID-19 cases.


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