Random forest can accurately predict the development of end-stage renal disease in immunoglobulin a nephropathy patients

Abstract Background Although end-stage renal disease (ESRD) is frequently used as an outcome marker for primary immunoglobulin A nephropathy (IgAN), the clinical course after reaching ESRD is not well documented. This study examined patients’ characteristics and survival in ESRD-related biopsy-proven IgAN in France. Methods French Renal Epidemiology and Information Network Registry data from 2010 to 2014 were used to analyse patients’ survival and outcome in incident ESRD patients >16 years of age with biopsy-proven primary IgAN, in comparison with other primary and secondary glomerulonephritis (GN), adult polycystic kidney disease (ADPKD) or diabetes. Multivariable survival analysis was adjusted for age, sex, time on dialysis and comorbidities. Results Among 17 138 incident dialysis patients with ESRD, IgAN (242.8/10 000 dialysis initiation) represents the most common GN related to ESRD during 2010. IgAN patients were the youngest, and had the fewest comorbidities and the highest use of peritoneal dialysis (PD) (17%). In comparison with the haemodialysis group, hazard ratios for death were not different in the preemptive transplantation group [0.46, 95% confidence interval (CI) 0.17–1.28] and in the PD group (0.77, 95% CI 0.44–1.33). Mortality rates in IgAN patients with preemptive transplantation and in those receiving dialysis waiting for transplantation were 2.9% (95% CI 0.0–5.6) and 6.7% (95% CI 0.9–12.3). Mortality rates of ADPKD patients receiving dialysis waiting for transplantation were higher (18%, 95% CI 3.1–30.6). Conclusion IgAN has the best prognosis among primary and secondary GN. IgAN patients receiving dialysis waiting transplantation seem to have a more favourable prognosis than ADPKD patients, who usually comprise the reference population. The underlying reasons for the difference in access treatment modalities should be investigated to improve survival with respect to renal disease.

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Long-term blood pressure behavior and progression to end-stage renal disease in patients with immunoglobulin A nephropathy

Journal of Hypertension ◽

10.1097/hjh.0000000000002354 ◽

2020 ◽

Vol 38 (5) ◽

pp. 925-935

Author(s):

Elisa Russo ◽

Daniela Verzola ◽

Gennaro Salvidio ◽

Barbara Bonino ◽

Daniela Picciotto ◽

...

Keyword(s):

Blood Pressure ◽

Renal Disease ◽

End Stage Renal Disease ◽

Immunoglobulin A ◽

Immunoglobulin A Nephropathy ◽

Pressure Behavior ◽

Stage Renal Disease ◽

End Stage

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Overestimation of the risk of progression to end-stage renal disease in the poor prognosis’ group according to the 2002 Japanese histological classification for immunoglobulin A nephropathy

Clinical and Experimental Nephrology ◽

10.1007/s10157-013-0848-y ◽

2013 ◽

Vol 18 (3) ◽

pp. 475-480 ◽

Cited By ~ 1

Author(s):

Yoichi Miyazaki ◽

Tetsuya Kawamura ◽

Kensuke Joh ◽

Hideo Okonogi ◽

Kentaro Koike ◽

...

Keyword(s):

End Stage Renal Disease ◽

Poor Prognosis ◽

Immunoglobulin A ◽

Histological Classification ◽

Immunoglobulin A Nephropathy ◽

The Poor ◽

Risk Of Progression ◽

Prognosis Group ◽

Stage Renal Disease ◽

End Stage

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Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes

Frontiers in Microbiology ◽

10.3389/fmicb.2021.752393 ◽

2021 ◽

Vol 12 ◽

Author(s):

Peng Zhang ◽

Jiali Fang ◽

Guanghui Li ◽

Lei Zhang ◽

Xingqiang Lai ◽

...

Keyword(s):

Renal Disease ◽

Intestinal Microbiota ◽

End Stage Renal Disease ◽

Immunoglobulin A ◽

Fecal Microbiota ◽

Microbiota Composition ◽

Stage Renal Disease ◽

End Stage ◽

Biochemical Indices ◽

Physiological And Biochemical

This study investigated the sex-specific differences in the correlation between intestinal microbiota and end-stage renal disease. Here, we compared the differences in the gut microbiota of male and female healthy controls (HC) and patients with end-stage renal disease (ESRD) caused by immunoglobulin A (IgA) nephropathy (ESRD-IgAN) or type-2 diabetes mellitus (ESRD-T2DM) using high-throughput sequencing of the 16S rRNA gene. We also analyzed the correlation between gut microbiota and clinical immune indicators. We assigned 8, 10, 5, 7, 11, and 20 volunteers to female HC, ESRD-IgAN, and ESRD-T2DM, and male HC, ESRD-IgAN, and ESRD-T2DM, respectively. The results showed sex-specific differences in both physiological and biochemical indices and intestinal microbiota composition, as well as the correlation between them. The correlations between physiological and biochemical indices in men were significantly lower than those in women, especially for indices related to immunity, blood glucose, and cardiac color sonography. Urine output, lymphocyte ratio, serum albumin, blood calcium, dialysis status, serum urea nitrogen, urine protein, and diabetes significantly correlated with male fecal microbiota composition, whereas only creatinine and 2-h post-prandial blood glucose significantly correlated with female fecal microbiota composition. The top 50 dominant operational taxonomic units showed a stronger correlation with physiological and biochemical indices in samples obtained from females than from males. These differences highlight sex-specific differences in the effectiveness of ESRD prevention and treatments via regulating intestinal microbiota.

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