Liquid-chromatographic determination of p-aminobenzoic acid in plasma to evaluate exocrine pancreatic function.

1985 ◽  
Vol 31 (6) ◽  
pp. 1073-1075 ◽  
Author(s):  
N Lawson ◽  
J D Berg ◽  
I Chesner
Keyword(s):  
Chromatographic Determination ◽  
Exocrine Pancreatic Function ◽  
Pancreatic Function ◽  
Aminobenzoic Acid ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Liquid Chromatographic Determination of Flucytosine in Capsules

1986 ◽  
Vol 69 (5) ◽  
pp. 825-826
Author(s):  
Donald Shostak ◽  
Clifford Klein
Keyword(s):  
Mobile Phase ◽  
Internal Standard ◽  
Chromatographic Determination ◽  
Aminobenzoic Acid ◽  
Reverse Phase ◽  
Acid Sodium Salt ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Abstract A liquid chromatographic method has been developed for determination of flucytosine in capsules. Flucytosine and p-aminobenzoic acid, the internal standard, are separated on a C18 reverse phase column using water-methanol-acetic acid mobile phase containing 1-octanesulfonic acid sodium salt. Compounds are detected photometrically at 285 nm. Mean assay results for 250 and 500 mg commercial capsules were 101.5% (n = 5) and 100.2% (n = 5) of declared, respectively. Mean recovery of flucytosine added to commercial capsules was 99.3 %.

Gas-Liquid Chromatographic Determination of Residues of Methane sulfonate of m-Aminobenzoic Acid Ethyl Ester in Fish

1977 ◽  
Vol 60 (4) ◽  
pp. 961-962
Author(s):  
Joe B Sills ◽  
Charles W Luhning
Keyword(s):  
Ethyl Ester ◽  
Acid Ethyl Ester ◽  
Chromatographic Determination ◽  
Fish Muscle ◽  
Aminobenzoic Acid ◽  
Flame Ionization ◽  
Chromatographic Procedure ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Abstract In this gas-liquid chromatographic procedure for determining residues of methanesulfonate of m-aminobenzoic acid ethyl ester (MS-222) in fish muscle, homogenized tissue is extracted with distilled water, and proteins are removed by coagulation with trichloroacetic acid, centrifugation, and filtration. After careful pH adjustment of the filtrate, MS-222 is partitioned into benzene-ethyl ether and measured by alkali flame ionization gas chromatography. Tissues with known additions of 1–19 μg MS-222/ g were analyzed, with recoveries of 84–95%.

Simultaneous Liquid Chromatographic Determination of Selected Tricyclic Antidepressants and Co-Administered Benzodiazepines

2016 ◽  
Vol 12 (6) ◽  
pp. 560-567
Author(s):  
Marwa F. Mansour ◽  
Ehab F. El-Kady ◽  
Mona M. Abd El-Moety ◽  
Nabawia M. El-Guindi ◽  
Ann Van Schepdael ◽  
...  
Keyword(s):  
Tricyclic Antidepressants ◽  
Chromatographic Determination ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Gas-Liquid Chromatographic Determination of Technical Chlordane Residues in Food Crops: Interpretation of Analytical Data

1975 ◽  
Vol 58 (5) ◽  
pp. 1051-1061
Author(s):  
William P Cochrane ◽  
James F Lawrence ◽  
Young W Lee ◽  
Ronald B Maybury ◽  
Brian P Wilson
Keyword(s):  
Field Experiments ◽  
Stationary Phases ◽  
Analytical Data ◽  
Chromatographic Determination ◽  
Electron Capture Detection ◽  
Food Crops ◽  
Liquid Chromatographic Determination ◽  
Consistent Method ◽  
Liquid Chromatographic

Abstract An interlaboratory investigation of technical chlordane residues in food crops was carried out to determine the most practical and consistent method of reporting results. Using a technical chlordane reference standard, 8 gas chromatographic stationary phases were studied for their resolution capabilities. The best separations were obtained with SE-30 and its OV-1 equivalent. Using these columns and electron capture detection, potatoes and carrots from supervised field experiments were analyzed in duplicate and quantitated by using 4 methods of calculation. The data were statistically treated to determine the precision and bias for each method. Also, 1 sample was analyzed in duplicate on 2 different occasions by 6 laboratories to substantiate the initial conclusions. Based on the criterion of high precision it is suggested that a comparison of total area under the chromatogram of the sample with total area of a standard technical chlordane be the method of quantitation. Only peaks which are common to both standard and sample have any significance in this type of calculation.

Liquid Chromatographic Determination of Amiodarone Hydrochloride and Related Compounds in Raw Materials and Tablets

1994 ◽  
Vol 77 (6) ◽  
pp. 1447-1453 ◽  
Author(s):  
Pauline M Lacrok ◽  
Norman M Curran ◽  
Wing-Wah Sy ◽  
Dennis K J Goreck ◽  
Pierre Thibault ◽  
...  
Keyword(s):  
Raw Materials ◽  
Chromatographic Determination ◽  
Raw Material ◽  
Liquid Chromatographic Method ◽  
Limit Of Quantitation ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic ◽  
Amiodarone Hydrochloride ◽  
Related Compounds

Abstract A liquid chromatographic method for the determination of amiodarone hydrochloride and 10 related compounds in drug raw material and for assay of drug in tablets was developed. The method specifies a 3 jxm Hypersil nitrile column (150 × 4.6 mm), a mobile phase of 1 + 1 acetonitrile–ammonium acetate buffer (0.1 M adjusted to pH 6.0 with 0.1 M acetic acid), a flow rate of 1 mL/min, and detection at 240 nm. The lower limit of quantitation of the related compounds is 0.02% or less. Drug contents in 2 raw material samples were 100.1 and 99.9% and ranged from 98.2 to 99.4% in 3 tablet formulations. Impurity levels in 2 samples of raw material from different manufacturers were ca 0.4%. The presence of 3 of the known related compounds in these samples was confirmed by liquid chromatographymass spectrometry. The method applied to raw materials was evaluated by a second laboratory and found to be satisfactory.

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