Influence of intermediate-density lipoproteins on the accuracy of the Friedewald formula

1991 ◽  
Vol 37 (8) ◽  
pp. 1394-1397 ◽  
Author(s):  
M Sentí ◽  
J Pedro-Botet ◽  
X Nogués ◽  
J Rubiés-Prat
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Percentage Error ◽  
Control Group ◽  
Low Density ◽  
The Mean ◽  
Friedewald Formula ◽  
Intermediate Density

Abstract Values of low-density lipoprotein (LDL) cholesterol (C) according to the Friedewald formula (Clin Chem 1972;18:499-502) were compared with those obtained by lipoprotein fractionation in 98 healthy subjects (control group), 135 specimens from patients with peripheral vascular and cerebrovascular disease (atherosclerotic group), and 45 with chronic renal failure on hemodialysis (CRF group). All had concentrations of total cholesterol between 3.23 and 7.76 mmol/L (1.25-3.00 g/L) and triglycerides less than 3.39 mmol/L (less than 3.00 g/L). The percentage error of calculated LDL-C was 4% in controls with a cholesterol/triglycerides (C/TG) ratio for very-low-density lipoprotein (VLDL) of 0.20, but greater than 60% in those with a (C/TG)VLDL ratio of 0.40. The percentage of error in sera of patients with atherosclerosis and chronic renal failure was higher than in controls with a similar mean (C/TG)VLDL ratio. The percentage of error of calculated LDL-C increases progressively with the increase in the C/TG intermediate-density lipoprotein (IDL) ratio, both in controls and in the atherosclerotic and CRF groups. Similar findings are observed when the mean percentage of error of measured LDL-C is evaluated. The percentage of error from calculated LDL-C in the atherosclerotic and CRF groups is significantly lower than that obtained by comparison of LDL-C separated by ultracentrifugation when the "broad cut" LDL (IDL plus LDL, both by ultracentrifugation) was used. The high percentage of errors found in the groups of patients studied underlines the need for caution when assessing the reliability of the Friedewald formula, particularly in cases in which disturbances in IDL composition are suspected.

scholarly journals Effect of Whole Quail (Coturnix japonica) Egg Consumption on some Reproductive Parameters and Lipid Profile of Male Albino Rat (Rattus norvegicus)

2017 ◽  
Vol 9 (3) ◽  
pp. 315-320 ◽  
Author(s):  
Chidozie N. OKOYE ◽  
Samuel O. EKERE ◽  
Onyinyechukwu A. AGINA ◽  
Ikechukwu J. UDEANI ◽  
Chukwunonso K. EZEASOR
Keyword(s):  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Low Density ◽  
Epididymal Sperm ◽  
Treatment Groups ◽  
Egg Consumption ◽  
Group A ◽  
The Mean

The present study evaluated the effect of whole egg consumption on the liver, testes, cauda epididymal sperm reserve and lipid profile of male rats. These evaluations were carried out on adult twenty (20) male albino rats, which were randomly selected into four groups of 5 rats each, designated groups A, B, C and D. Group A was the control group and received only equivalent volume of distilled water, while groups B, C and D received 0.25mg/kg, 0.5mg/kg; and 1.0mg/kg body weight of the quail egg respectively. Standard procedures were carried out in the tissue processing, cauda epididymal sperm reserve and in lipid profile determinations. On days 35 and 49, the mean serum total cholesterol value of group D was significantly lower than that of the control group. On day 35, the mean serum low density lipoprotein and high density lipoprotein (LDL and HDL cholesterol) values of all the treatment groups were significantly lower and higher than that of the control group, respectively. However, on days 49 and 63, the mean serum very low density lipoprotein (VLDL cholesterol) and triglyceride values of all the treatment groups were significantly higher than that of the control group. A significant increase in cadual epididymal sperm count (CESR) was recorded on day 63 at the mid and high doses. No obvious pathological lesions were observed in the histomorphology of the testes and liver when compared to the control. Therefore, whole quail egg consumption caused an increase in serum triglyceride and very low density lipoprotein concentration, and also improved fertility. In other words, prolonged consumption of quail egg should be done with caution as it may predispose one to cardiovascular disease.

scholarly journals Low-density lipoprotein clearance in patients with chronic renal failure

2009 ◽  
Vol 24 (7) ◽  
pp. 2131-2135 ◽  
Author(s):  
Helena Kastarinen ◽  
Sohvi Hörkkö ◽  
Heikki Kauma ◽  
Anna Karjalainen ◽  
Markku J. Savolainen ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density

scholarly journals Cardiovascular Disease in Women with Chronic Renal Failure

2015 ◽  
Vol 16 (1) ◽  
pp. 14-17
Author(s):  
Nwamaka Chiji Okenzere ◽  
Chukwubike Udoka Okeke
Keyword(s):  
Cardiovascular Disease ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Low Density Lipoprotein ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Dialysis Treatment ◽  
Female Patients

Objective: Patients with chronic renal failure have high burden of cardiovascular morbidity and mortality. This study was carried out to investigate the development of cardiovascular disease in chronic renal failure among female patients on dialysis treatment in Nigeria. Materials and Methods: A total of 40 adult female subjects participated in this study. 20 of them were apparently healthy and served as control group while the rest 20 were female patients with chronic renal failure (CRF) on dialysis treatment. Fasting blood samples were collected and their lipid profile, Total Cholesterol (TC), Triglyceride (TG), High Density Lipoprotein –Cholesterol (HDL-C), Low Density Lipoprotein –Cholesterol (LDL-C), and Very Low Density Lipoprotein –Cholesterol (VLDL-C) were estimated using enzymatic methods. The percentages of these parameters in circulation were obtained. The cardiovascular risk ratios (TC/HDL-C and LDL-C/HDL-C) were calculated. Result: The lipid profile of the chronic renal failure patients (TC 5.70±0.80mmol/l, TG 1.46±0.40mmol/l, LDL-C 3.50±0.2mmol/l, and VLDL-C 0.67±0.2mmol/l) were significantly higher (p<0.05) than that of control group (TC 4.03±0.13mmol/l, TG 1.10± 0.3mmol/l , LDL-C 1.85±0.5mmol/l, and VLDL-C 0.50± 0.01mmol/l) except HDL-C. HDL-C of the CRF patients (1.40±0.2mmol/l) was significantly lower (p<0.05) than that of healthy women (HDL-C 1.70± 0.04mmol/l). These depict no difference in the percentage of VLDL-C & TG in circulation between the control (VLDL –C 5% and TG 45%) and chronic renal failure patients (VLDL –C 5% and TG 44%). In CRF group, it was observed that 28% of the total plasma lipid (12.73mmol/l) was LDL-C but in healthy women, percentage of LDL-C in circulation (out of 9.18mmol/l) was 20%. It was also observed that 11% of the total plasma lipid (12.73mmol/l) in CRF patients was HDL-C but in healthy subjects, the percentage of HDL-C in circulation (out of 9.18mmol/l) was 19%. The cardiovascular risk indices (TC/HDL-C and LDL-C/HDL-C) of the CRF patients (TC/HDL-C 3.91±0.24 and LDL-C/HDL-C 2.50±0.01) were significantly higher (p<0.05) than those of the healthy subjects (TC/HDL-C 2.40±0.09, LDL-C/HDL-C 1.10±0.08). Conclusion: These results indicate that chronic renal failure is a risk factor to development of cardiovascular disease in female patients on dialysis.DOI: http://dx.doi.org/10.3329/jom.v16i1.22382 J MEDICINE 2015; 16 : 14-17

Compositional Lipoprotein Changes and Low-Density Lipoprotein Susceptibility to Oxidation in Chronic Renal Failure Patients with Heavy Proteinuria

2004 ◽  
Vol 95 (3) ◽  
pp. c77-c83 ◽  
Author(s):  
Sonia Athena Karabina ◽  
Haralampos Pappas ◽  
George Miltiadous ◽  
Eleni Bairaktari ◽  
Dimitris Christides ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Heavy Proteinuria

scholarly journals Lipid Profile in Preeclampsia Patients as Compared to Normal Patient

2020 ◽  
Vol 22 (4) ◽  
pp. 238-242
Author(s):  
Sanita Kayastha ◽  
B Tiwari ◽  
R Subedi
Keyword(s):  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
College Teaching ◽  
Test Group ◽  
Control Group ◽  
Low Density ◽  
Medical College ◽  
The Mean ◽  
Severity Of The Disease

The main objective of the study was to see the association of dyslipidemia in preeclampsia (PET) as compare to normotensive (NT) patients. It was a descriptive study done in Nepal Medical College Teaching Hospital Department of Obstetrics and Gynecology from April 2019 from April 2020. A total of 75 PET (test group) and 75 NT (control group) in their third trimester were included. Their fasting lipid profile was studied. It was found that triglyceride (TG) and very low density lipoprotein (VLDL) was significantly high among PET group as compared to that of NT patients. The mean TG of PET group was 266.11± 98.61 and the NT group was 187±58.56 (p=0.00) and the mean VLDL of PET group was 46.00±15.31 and NT group was 37.88±12.85 (p=0.001). On the other hand, the total cholesterol (TC), low density lipoprotein (LDL) and high density lipoprotein (HDL) were not significantly different in both the groups. It was also found that with the severity of the disease (Preeclampsia), the level of TG and VLDL increased significantly. Therefore, among the investigation done for PET, we should include lipid profile, especially the TG and VLDL. Furthermore, TG and VLDL should be measured serially (at least once a week) so as to predict the progress of PET and manage the patient accordingly.

scholarly journals Decreased clearance of low-density lipoprotein in patients with chronic renal failure

1994 ◽  
Vol 45 (2) ◽  
pp. 561-570 ◽  
Author(s):  
Sohvi Hörkkö ◽  
Kaisa Huttunen ◽  
Taina Korhonen ◽  
Y. Antero Kesäniemi
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density
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