scholarly journals Short- and long-term reproducibility of the 1-h 50-g glucose challenge test

1996 ◽  
Vol 42 (2) ◽  
pp. 255-257 ◽  
Author(s):  
G Phillipov
Keyword(s):  
Pregnant Women ◽  
Challenge Test ◽  
Total Sample ◽  
Oral Glucose ◽  
True Value ◽  
Glucose Challenge Test ◽  
Significant Difference ◽  
Glucose Challenge ◽  
Short And Long Term

Abstract A study was undertaken to assess the short-term (intrapregnancy) and long-term (interpregnancy) variability of the 1-h 50-g oral glucose challenge test (GCT). Two groups of pregnant women had GCTs in consecutive pregnancies, 1 (n = 77) and 2 (n = 43) years apart. Their results were compared with published results for a group (n = 53) who had GCTs on consecutive days. Robust estimates of the mean error variance (sigma2 error = sigma2 within-individual + sigma2 analytical) were calculated on log10-transformed data and were for the three groups 0.003995, 0.002603, and 0.0026249 (mg/dL)2, respectively. There was no significant difference between the group variances, establishing that the short- and long-term reliability of the GCT is comparable. Sigma2 between-individuals was estimated from the GCT values for 2695 pregnant women tested during the same period and was the main component (67.1%) of the total sample variation (sigma2 between-individuals / sigma2 population). Estimates of the population mean, sigma2 between-individuals, and sigma2 error were used to compute the probability that an observed GCT value had a true value equal to or greater than the consensus threshold of 7.8 mmol/L (140 mg/dL).

scholarly journals The Glucose Challenge Test for Screening of Gestational Diabetes

2012 ◽  
Vol 9 (2) ◽  
pp. 22-25 ◽  
Author(s):  
A Shrestha ◽  
C D Chawla
Keyword(s):  
Gestational Diabetes ◽  
Pregnant Women ◽  
Diagnostic Yield ◽  
Mode Of Delivery ◽  
Challenge Test ◽  
Tolerance Test ◽  
Modern Trend ◽  
Oral Glucose ◽  
Glucose Challenge Test ◽  
Glucose Challenge

Background The frequency of gestational diabetes mellitus (GDM) is 0.6% -15% of pregnant woman. The modern trend towards the delay starting family is the main factor responsible for increase prevalence of GDM. This condition is associated with the adverse effect on mother and fetus, so it is important to find out the GDM by screening of all the pregnant women. Objective To observe the feasibility of using the 50g GCT for all pregnant women attending Dhulikhel Hospital, Obstetric OPD. To determine the incidence of gestational diabetes in the population and to observe the maternal and fetal outcome among those having an elevated GCT level and gestational diabetes. Methods A prospective and analytical study of 1598 pregnant women booked and delivered between June 2009and August 2010. Glucose challenge test (GCT) performed by using 50gm glucose and diagnosis of gestational diabetes performed by using the Carpenter Coustan Criteria. Pregnancy outcomes were assessed by the gestation and mode of delivery. Similarly, neonatal outcomes assessed in terms of birth weights, APGAR scores, congenital abnormalities, hyperbilirubinaemia, hypoglycaemia or respiratory distress syndrome. Results The detected incidence of gestational diabetes was 0.75%. With the threshold plasma glucose level at140 mg/ dl, 198 women needed to undergo the 100g oral glucose tolerance test and 12 women had gestational diabetes. The diagnostic yield was 6.06%. Perinatal outcome was similar to the rest of the women with normal glucose challenge test. Conclusions The 50g GCT is feasible and also helps to find out GDM. It is easy, user friendly, cheap and convenient for screening purpose. DOI: http://dx.doi.org/10.3126/kumj.v9i2.6282  Kathmandu Univ Med J 2011;9(2):22-25

Comparison of Obstetric and Neonatal Outcomes According to Oral Glucose Challenge Test in Korean Pregnant Women

2013 ◽  
Vol 24 (3) ◽  
pp. 180 ◽  
Author(s):  
Sung Hyun Yun ◽  
Sang Won Han ◽  
San Hui Lee ◽  
Yong Wook Jung ◽  
Euy Hyuk Kim
Keyword(s):  
Pregnant Women ◽  
Challenge Test ◽  
Neonatal Outcomes ◽  
Oral Glucose ◽  
Glucose Challenge Test ◽  
Glucose Challenge

Maternal hypoglycemia on 50 g glucose challenge test: outcomes are influenced by fetal gender

2016 ◽  
Vol 44 (4) ◽  
Author(s):  
Hasan Onur Topçu ◽  
Can Tekin İskender ◽  
Şevki Çelen ◽  
Aslı Oskovi ◽  
Dilek Uygur ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Challenge Test ◽  
Perinatal Outcomes ◽  
Maternal Plasma ◽  
Control Group ◽  
Oral Glucose ◽  
Second Trimester ◽  
Retrospective Case ◽  
Glucose Challenge Test ◽  
Glucose Challenge

AbstractTo assess the perinatal outcomes in pregnant women with maternal hypoglycemia following a second trimester oral glucose challenge test (GCT).This retrospective case control study consisted of 2091 pregnant women with hypoglycemia (glucose levels >88 mg/dL 1 h following a 50 g GCT in the second trimester of pregnancy) and a control group of 2091 pregnant women with a GCT result between 88 and 130 mg/dL. Perinatal and neonatal characteristics obtained from electronic medical records were compared between groups.The rates of pregnancy complications were similar in both groups, with the exception of a lower incidence of polyhydramnios and a higher rate of deliveries before the 34A low maternal plasma glucose level on the GCT is associated with favorable outcomes, such as decreased rates of birth trauma and neonatal hypoglycemia. In addition, male infants have a higher risk of being SGA than female infants when maternal GCT results were <88 mg/dL.

scholarly journals The application of 50g oral glucose challenge test in screening for gestational diabetes mellitus in patients attending antenatal care OPD

2017 ◽  
Vol 6 (5) ◽  
pp. 1952
Author(s):  
Disha Andhiwal Rajput ◽  
Jaya Kundan Gedam
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Plasma Glucose ◽  
Gestational Hypertension ◽  
Challenge Test ◽  
Oral Glucose ◽  
Average Risk ◽  
Glucose Challenge Test ◽  
Glucose Challenge

Background: To screen patients at average risk for Gestational Diabetes using 50g Glucose Challenge test, to ascertain the prevalence of Gestational diabetes through further diagnostic testing and to prevent and manage complications. Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance of variable severity with onset or first recognition during pregnancy. Women with GDM are at risk for maternal and foetal complications, so it is important to screen all the pregnant woman.Methods: This study was conducted in 198 patients between 24 and 28 weeks of gestation, attending the Antenatal clinic. 50g oral glucose is administered irrespective of time of the last meal and plasma glucose is measured one hour later. Patients with plasma glucose levels more than 140 mg/dl were subjected to a 100g oral glucose tolerance test, patients with two or more abnormal reading were labelled as GDM and managed accordingly.Results: Prevalence of GDM in our study was 9.59%. Maternal complications like gestational hypertension, vaginal infections and foetal complications were much higher in GDM patients as compare to non GDM group.Conclusions: GDM is a disease which adversely affects both mother as well as foetus. It is concluded that 50 gm glucose challenge test at 24-28 weeks of gestation with a cut-off value of 140 mg/dl is a reliable screening test for GDM. This test offers the best combination of ease and economy of use and reproducibility in screening for gestational diabetes mellitus in average risk patients.

scholarly journals One step oral glucose challenge test as screening and diagnostic test for Gestational Diabetes Mellitus

2019 ◽  
Vol 14 (2) ◽  
pp. 42-45
Author(s):  
Manisha Yadav ◽  
Gehanath Baral
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Diagnostic Test ◽  
Challenge Test ◽  
Single Step ◽  
Oral Glucose ◽  
Fasting State ◽  
Glucose Challenge Test ◽  
Glucose Challenge

Aim: The Diabetes in Pregnancy Study Group of India (DIPSI, 2010) guidelines recommend the non-fasting 75-g oral glucose challenge test (OGCT) as a single-step screening and diagnostic test for gestational diabetes mellitus (GDM). The aim of this study was to assess the validity of DIPSI criteria by comparing with the World Health Organization (WHO) 1999 criteria of diagnosing GDM. Methods: This study was a hospital based prospective comparative study conducted among 282 pregnant women, of gestational age of 24-28 weeks attending antenatal OPD of Patan hospital. The OGCT was performed on them irrespective of fasting state and without any dietary preparation and they were again asked to come after 3 days of unrestricted carbohydrate diet in fasting state for WHO 2-hour oral glucose tolerance test (OGTT) with 75 gram of glucose load. The value of OGCT >140 mg/dl is diagnostic of GDM (DIPSI 2010). For the reliability of this test, it was compared with WHO 2-hour OGTT. Results: Among the study population, the mean age and BMI was 26.04±4.50 and 24.08±3.30 respectively. Out of 282 patients, 8 cases (2.83%) were found to have abnormal non-fasting 75-g OGCT and 4 cases (1.41%) had abnormal WHO 2-hour OGTT. Paired t test was employed to examine the difference of blood glucose level of the tests. There was statistically significant difference (p<0.001) between the tests. The Sensitivity, specificity, positive predictive value and negative predictive value of oral glucose challenge test was 25%, 97.48%, 12.5% and 98.90% respectively. The non- fasting 75-g OGCT was able to detect only 25% of the cases. Conclusions: Though the non-fasting 75-g OGCT test is cost effective and more compliant to pregnant women, the present report suggests that it cannot be used as a single step screening and diagnostic test because of its low sensitivity. However, it is an adequate alternative for screening test in resources limited areas.

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