scholarly journals Antioxidative enzyme activities in human erythrocytes

1997 ◽  
Vol 43 (4) ◽  
pp. 562-568 ◽  
Author(s):  
Helle Raun Andersen ◽  
Jesper B Nielsen ◽  
Flemming Nielsen ◽  
Philippe Grandjean
Keyword(s):  
Enzyme Activities ◽  
Tobacco Consumption ◽  
Human Erythrocytes ◽  
Copper Zinc Superoxide Dismutase ◽  
Zinc Superoxide Dismutase ◽  
Age Related ◽  
Antioxidative Enzyme Activities ◽  
Copper Zinc ◽  
High Degree ◽  
Age Related Changes

Abstract Reliable and standardized methods are necessary to determine the expression of antioxidative enzymes and their role in maintaining health. In addition, the variability of the enzyme activities within the general population caused by age, gender, and life-style factors must be described. This study describes methodological conditions that are suitable for analyzing copper–zinc superoxide dismutase (CuZn-SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and glutathione reductase (GR) in human erythrocytes with a high degree of reproducibility. Intervals for the enzyme activities have been established in a randomly selected population of 220 individuals between 20 and 89 years of age. An age-related decrease was observed in CuZn-SOD and GR activities, whereas no age-related changes were demonstrated for GSH-Px and CAT. The GSH-Px activity was positively associated with the intake of dietary supplements and negatively correlated with tobacco consumption. These factors probably account for the fact that women tended to have higher GSH-Px activity.

Age-Correlated Modifications of Copper-Zinc Superoxide Dismutase and Glutathione-Related Enzyme Activities in Human Erythrocytes

1992 ◽  
Vol 38 (1) ◽  
pp. 66-70 ◽  
Author(s):  
Iréne Ceballos-Picot ◽  
Jean-Marc Trivier ◽  
Annie Nicole ◽  
Pierre-Marie Sinet ◽  
Marc Thevenin
Keyword(s):  
Superoxide Dismutase ◽  
Enzyme Activities ◽  
Human Erythrocytes ◽  
Copper Zinc Superoxide Dismutase ◽  
Zinc Superoxide Dismutase ◽  
Age Related ◽  
Copper Zinc ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

Abstract To obtain a comprehensive profile of the erythrocyte antioxidant defense potential during aging, we investigated copper-zinc superoxide dismutase (CuZn-SOD), seleno-dependent glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-RD), and glutathione-S-transferase (GSH-S-T) activities in human erythrocytes from 167 apparently healthy subjects, ages one month to 63 years (102 females, 65 males). We found a negative correlation between age and activities of CuZn-SOD (r = 0.362, P less than 0.001), GSSG-RD (r = 0.549, P less than 0.001), and GSH-S-T (r = 0.575, P less than 0.001). In contrast, we found a positive correlation between age and GSH-Px activity (r = 0.401, P less than 0.001). To evaluate aging changes, we divided the subjects into five groups: Group 1 (newborn-age one year), Group 2 (1-11 years), Group 3 (11-25 years), Group 4 (25-40 years), and Group 5 (40-63 years). Significant age-related modifications in erythrocyte enzyme activities appeared in Group 3 for CuZn-SOD, GSSG-RD, and GSH-Px activity, whereas for GSH-S-T activity age-related modifications appeared in Group 2. We found no sex-related differences in erythrocyte CuZn-SOD, GSSG-RD, GSH-Px, and GSH-S-T activities.

scholarly journals Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Kenji Watanabe ◽  
Shuichi Shibuya ◽  
Yusuke Ozawa ◽  
Hidetoshi Nojiri ◽  
Naotaka Izuo ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Oxidative Damage ◽  
Molecular Mechanisms ◽  
The Body ◽  
Copper Zinc Superoxide Dismutase ◽  
Zinc Superoxide Dismutase ◽  
Age Related ◽  
Tissue Changes ◽  
Copper Zinc

Aging is characterized by increased oxidative stress, chronic inflammation, and organ dysfunction, which occur in a progressive and irreversible manner. Superoxide dismutase (SOD) serves as a major antioxidant and neutralizes superoxide radicals throughout the body.In vivostudies have demonstrated that copper/zinc superoxide dismutase-deficient (Sod1−/−) mice show various aging-like pathologies, accompanied by augmentation of oxidative damage in organs. We found that antioxidant treatment significantly attenuated the age-related tissue changes and oxidative damage-associated p53 upregulation inSod1−/−mice. This review will focus on various age-related pathologies caused by the loss ofSod1and will discuss the molecular mechanisms underlying the pathogenesis inSod1−/−mice.

Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase

1999 ◽  
Vol 20 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Sandra L McFadden ◽  
Dalian Ding ◽  
Andrew G Reaume ◽  
Dorothy G Flood ◽  
Richard J Salvi
Keyword(s):  
Superoxide Dismutase ◽  
Hair Cell ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Copper Zinc Superoxide Dismutase ◽  
Cochlear Hair Cell ◽  
Zinc Superoxide Dismutase ◽  
Age Related ◽  
Copper Zinc

Effect of Copper-Zinc Superoxide Dismutase on Endothelium-Dependent Vasodilation in Patients With Essential Hypertension

Hypertension ◽  
1995 ◽  
Vol 26 (6) ◽  
pp. 863-868 ◽  
Author(s):  
Carlos E. García ◽  
Crescence M. Kilcoyne ◽  
Carmine Cardillo ◽  
Richard O. Cannon ◽  
Arshed A. Quyyumi ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Essential Hypertension ◽  
Copper Zinc Superoxide Dismutase ◽  
Zinc Superoxide Dismutase ◽  
Copper Zinc ◽  
Effect Of Copper
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