Approaches to the development of selective inhibitors of vascular smooth muscle cell proliferation

1993 ◽  
Vol 27 (7) ◽  
pp. 1191-1198 ◽  
Author(s):  
P. L Weissberg ◽  
D. J Grainger ◽  
C. M Shanahan ◽  
J. C Metcalfe
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Smooth Muscle Cell Proliferation ◽  
Selective Inhibitors

Involvement of Cyclooxygenase- and Lipoxygenase-Mediated Conversion of Arachidonic Acid in Controlling Human Vascular Smooth Muscle Cell Proliferation

1990 ◽  
Vol 63 (02) ◽  
pp. 291-297 ◽  
Author(s):  
Herm-Jan M Brinkman ◽  
Marijke F van Buul-Worteiboer ◽  
Jan A van Mourik
Keyword(s):  
Cell Proliferation ◽  
Arachidonic Acid ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Muscle Cells ◽  
Smooth Muscle Cell Proliferation

SummaryWe observed that the growth of human umbilical arterysmooth muscle cells was inhibited by the phospholipase A2 inhibitors p-bromophenacylbromide and mepacrine. Thesefindings suggest that fatty acid metabolism might be integrated in the control mechanism of vascular smooth muscle cell proliferation. To identify eicosanoids possibly involved in this process, we studied both the metabolism of arachidonic acid of these cells in more detail and the effect of certain arachidonic acid metabolites on smooth muscle cells growth. We found no evidence for the conversion of arachidonic acid via the lipoxygenase pathway. In contrast, arachidonic acid was rapidly converted via the cyclooxy-genase pathway. The following metabolites were identified: prostaglandin E2 (PGE2), 6-keto-prostaglandin F1α (6-k-PGF1α), prostaglandin F2α (PGF2α), 12-hydroxyheptadecatrienoic acid (12-HHT) and 11-hydroxyeicosatetetraenoic acid (11-HETE). PGE2 was the major metabolite detected. Arachidonic acid metabolites were only found in the culture medium, not in the cell. After synthesis, 11-HETE was cleared from the culture medium. We have previously reported that PGE2 inhibits the serum-induced [3H]-thymidine incorporation of growth-arrested human umbilical artery smooth muscle cells. Here we show that also 11-HETEexerts this inhibitory property. Thus, our data suggeststhat human umbilical artery smooth muscle cells convert arachidonic acid only via the cyclooxygenase pathway. Certain metabolites produced by this pathway, including PGE2 and 11-HETE, may inhibit vascular smooth muscle cell proliferation.

Influence of Endothelium on Cultured Vascular Smooth Muscle Cell Proliferation

Hypertension ◽  
1995 ◽  
Vol 25 (4) ◽  
pp. 748-751 ◽  
Author(s):  
Concepción Peiró ◽  
Juliana Redondo ◽  
M. Angeles Rodríguez-Martínez ◽  
Javier Angulo ◽  
Jesús Marín ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Smooth Muscle Cell Proliferation

Nebivolol inhibits vascular smooth muscle cell proliferation by mechanisms involving nitric oxide but not cyclic GMP

Nitric Oxide ◽  
2002 ◽  
Vol 7 (2) ◽  
pp. 83-90 ◽  
Author(s):  
Louis J Ignarro ◽  
Manisha Sisodia ◽  
Kim Trinh ◽  
Sahar Bedrood ◽  
Guoyao Wu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Proliferation ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Cyclic Gmp ◽  
Smooth Muscle Cell Proliferation

Exploring the molecular mechanisms of OSU-03012 on vascular smooth muscle cell proliferation

2010 ◽  
Vol 344 (1-2) ◽  
pp. 81-89 ◽  
Author(s):  
Wei-Wen Kuo ◽  
Jing-Ru Weng ◽  
Chih-Yang Huang ◽  
Chang-Hai Tsai ◽  
Wei-Hung Liu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Molecular Mechanisms ◽  
Smooth Muscle Cell Proliferation
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