scholarly journals P637 MMP-2 and -8 degraded and citrullinated-vimentin (VICM) correlates to disease activity in inflammatory bowel diseases

2019 ◽  
Vol 13 (Supplement_1) ◽  
pp. S436-S437
Author(s):  
L Godskesen ◽  
M Lindholm ◽  
J Høg Mortensen ◽  
A Krag ◽  
T Manon-Jensen ◽  
...  
Keyword(s):  
Disease Activity ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Citrullinated Vimentin ◽  
Inflammatory Bowel

scholarly journals Mo1831 – Mmp-2 and -8 Degraded and Citrullinated-Vimentin (VICM) Correlates to Disease Activity in Inflammatory Bowel Diseases

2019 ◽  
Vol 156 (6) ◽  
pp. S-854
Author(s):  
Line E. Godskesen ◽  
Majken Lindholm ◽  
Joachim Høg Mortensen ◽  
Aleksander Krag ◽  
Tina Manon-Jensen ◽  
...  
Keyword(s):  
Disease Activity ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Citrullinated Vimentin ◽  
Inflammatory Bowel

Implications of Dietary Impact on Hepatic Steatosis and IBD

2020 ◽  
Vol 27 (1) ◽  
pp. 10-11
Author(s):  
Yejoo Jeon ◽  
Berkeley N Limketkai
Keyword(s):  
Disease Activity ◽  
Hepatic Steatosis ◽  
Mediterranean Diet ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
The Mediterranean

The Mediterranean diet was recently shown to benefit hepatic steatosis and disease activity in inflammatory bowel diseases. These findings advance our knowledge on dietary approaches for IBD and motivate inquiry on the role of obesity in IBD pathogenesis.

IRF5 Acts as a Potential Therapeutic Marker in Inflammatory Bowel Diseases

2020 ◽  
Author(s):  
Yonghong Yang ◽  
Cui Zhang ◽  
Dehuai Jing ◽  
Heng He ◽  
Xiaoyu Li ◽  
...  
Keyword(s):  
T Cells ◽  
Disease Activity ◽  
Inflammatory Bowel Diseases ◽  
Peripheral Blood ◽  
Cd4 T Cells ◽  
Mononuclear Cells ◽  
Orphan Receptor ◽  
Peripheral Blood Mononuclear ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Abstract Background Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn’s disease (CD), are chronic inflammatory disorders. As is well known, interferon regulatory factor (IRF) 5 is closely associated with the pathogenesis of various inflammatory diseases. But the exact role of IRF5 in IBD remains unclear. Methods In this study, we detected IRF5 expression in peripheral blood mononuclear cells (PBMCs) and inflamed mucosa from IBD patients by immunohistochemistry, western blot, and quantitative real-time polymerase chain reaction. Peripheral blood CD4+ T cells were stimulated with inflammatory cytokines and transfected by lentivirus. Results In active IBD patients, the expression of IRF5 in PBMCs and inflamed colonic tissues was obviously increased and significantly associated with disease activity. Ectopic overexpression of IRF5 could promote the differentiation of IBD CD4+ T cells into Th1 and Th17 cells by regulating T-bet and RAR related orphan receptor C, whereas knockdown of IRF5 had the opposite effects. Tumor necrosis factor (TNF)-α upregulated expression of IRF5 in CD4+ T cells, but anti-TNF treatment with infliximab could markedly reduce IRF5 expression in CD4+ T cells and intestinal mucosa of CD patients. Conclusion Our study reveals a novel mechanism that IRF5 levels are correlated with disease activity in IBD and might function as a possible marker for the management of IBD via regulating Th1 and Th17 immune responses and cytokine production.

Is ischemia modified albumin a disease activity marker for inflammatory bowel diseases?

2016 ◽  
Vol 31 (6) ◽  
pp. 1120-1125 ◽  
Author(s):  
Mustafa Kaplan ◽  
Mahmut Yuksel ◽  
Ihsan Ates ◽  
Zeki Mesut Yalın Kilic ◽  
Hasan Kilic ◽  
...  
Keyword(s):  
Disease Activity ◽  
Inflammatory Bowel Diseases ◽  
Ischemia Modified Albumin ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Activity Marker

scholarly journals Paternal Disease Activity Is Associated With Difficulty in Conception Among Men With Inflammatory Bowel Diseases

2019 ◽  
Vol 17 (1) ◽  
pp. 203-204
Author(s):  
Ashwin N. Ananthakrishnan ◽  
Christopher Martin ◽  
Sunanda Kane ◽  
Robert S. Sandler ◽  
Millie D. Long
Keyword(s):  
Disease Activity ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel
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