The association between acute-to-chronic glycemic ratio and outcome in acute heart failure

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
I Teraguchi ◽  
T Imanishi ◽  
K Komukai ◽  
T Tamaki ◽  
S Imamura ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Glucose ◽  
Acute Heart Failure ◽  
Independent Predictor ◽  
Elevated Blood ◽  
Glucose Levels ◽  
Elevated Blood Glucose ◽  
Elevated Blood Glucose Level ◽  
Multiple Variable ◽  
The Relationship

Abstract Introduction Elevated blood glucose level on admission worsen outcome in acute heart failure (AHF). The admission blood glucose (ABG)/ the estimated average glucose (eAG) ratio which combines both acute and chronic glucose levels is attracting attention as a newly introduced glycemic index. It may be accepted as indicating the true acute glycemic rise in critically in all patients. Purpose The aim of this study was to assess the association between acute-to-chronic glycemic ratio and outcome in AHF. Methods This study assessed consecutive patients with AHF. The ABG/ eAG ratio was determined as ABG divided by eAG. We examined the relationship between ABG/ eAG ratio and all-cause mortality and readmission for heart failure within 30 days. Results A total of 249 patients with AHF (mean age; 81 years, 50% male and 37% DM) were studied. 31 (12.4%) patients had events within 30 days [18 (7.2%) died and 13 (5.2%) readmitted for HF]. We divided into three tertiles [T1 (<0.93), T2 (0.93–1.21) and T3 (>1.21)] based on the ABG/ eAG ratio. There was a stepwise worsening of the 30 days outcome [1 patient (0.4%) vs 7 patients (2.8%) vs 23 patients (9.2%), p<0.0001]. In multiple variable analysis, ABG/ eAG ratio was an independent predictor of the events (p=0.002). A cut-off value of the ABG/ eAG ratio <1.11 had a sensitivity of 94% and specificity of 67% for the increase of events within 30 days. In full model, the ABG/ eAG ratio was independent predictor of 30 days outcome in AHF (odds ratio: 11.7; 95% confidence interval: 3.65–37.5; p<0.0001). Conclusion ABG/ eAG ratio was one of the strong predictors 30 days outcome in AHF. Elevated blood glucose in the acute phase evaluated using the ABG/ eAG ratiocan enhance affect outcome and it could be a potential therapeutic target in patients of AHF. Funding Acknowledgement Type of funding source: None

scholarly journals Association Between Elevated Blood Glucose and Outcome in Acute Heart Failure

2013 ◽  
Vol 61 (8) ◽  
pp. 820-829 ◽  
Author(s):  
Alexandre Mebazaa ◽  
Etienne Gayat ◽  
Johan Lassus ◽  
Taly Meas ◽  
Christian Mueller ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Glucose ◽  
Acute Heart Failure ◽  
Elevated Blood ◽  
Elevated Blood Glucose

scholarly journals Foods for Specialized Health Use (FOSHU) in Treating Postprandial Elevated Blood Glucose Level

2008 ◽  
Vol 5 (2) ◽  
pp. 123-134 ◽  
Author(s):  
Hirotaka HAYASHI ◽  
Satoshi OHNO ◽  
Takanari ARAI ◽  
Masuo NAKAI ◽  
Yoshio KATO ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Elevated Blood ◽  
Elevated Blood Glucose ◽  
Elevated Blood Glucose Level

scholarly journals Uji efek ekstrak buah okra (Abelmoschus esculentus) terhadap kadar glukosa darah pada tikus wistar (Rattus norvegicus) yang diinduksi aloksan

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Leonardus B.A. Prakoso ◽  
Christi Mambo ◽  
Mona P. Wowor
Keyword(s):  
Blood Glucose ◽  
Wistar Rats ◽  
Negative Control Group ◽  
Negative Control ◽  
Abelmoschus Esculentus ◽  
Control Group ◽  
Elevated Blood ◽  
Glucose Levels ◽  
Elevated Blood Glucose ◽  
Blood Glucose Levels

Abstract: Okra (Abelmoschus esculentus) is one of many herbal medicine that have been used worldwide to prevent and treat diabetes mellitus. This research aimed to evaluate the effect of garlic bulbs extract administration on elevated blood glucose levels on Wistar rats (R. norvegicus) induced by alloxan. The subject in this research were male Wistar rats with total of 15 samples divided into 5 groups, consisting of one negative control group, one positive control group who were induce by 130 mg/kgBW of alloxan that cause the Rats in conditions of hyperglycemic, and three groups of Rats were given okra extract with dose of 0.375 ml/100 gBW of rat, 0.75 ml/100 gBW of rat , and 1.5 ml/100 gBW of rat. Blood glucose levels was measured on day zero, day one and day two every thirty minutes on 0, 30, 60, 90, 120, and every six hours on 0, 6, 12, 18, and 24. Data from the measurement showed that 0.375 ml/100 gBW, 0.75 ml/100 gBW , and 1.5 ml/100 gBW of okra extract can’t reduce elevated blood glucose levels on Wistar rats.Keywords: Abelmoschus esculentus, okra, blood glucose levels, alloxan Abstrak: Buah Okra (Abelmoschus esculentus) diyakini masyarakat sebagai salah satu tanaman obat yang mampu mencegah dan mengobati penyakit diabetes. Penelitian ini bertujuan untuk menguji apakah pemberian ekstrak buah okra dapat menurunkan kadar glukosa darah tikus Wistar (R. norvegicus) yang diinduksi aloksan. Subjek penelitian berupa tikus Wistar berjumlah 15 ekor yang dibagi dalam 5 kelompok, terdiri atas satu kelompok kontrol negatif, satu kelompok kontrol positif yang diberi aloksan dengan dosis 130 mg/kgBB yang menyebabkan tikus Wistar dalam keadaan hiperglikemik yang kemudian diinsuksi insulin, dan tiga kelompok Tikus hiperglikemik diberi ekstrak buah okra dengan dosis 0,375 ml/100 gBB tikus, 0,75 ml/100 gBB tikus, dan 1,5 ml/100 gBB tikus. Data diperoleh dari pemeriksaan kadar glukosa darah pada semua kelompok tikus Wistar pada hari ke nol, pertama, dan kedua pada menit ke-0, 30, 60, 90, 120 dan jam ke-0, 6, 12, 18, dan 24. Hasil penelitian menunjukkan bahwa pemberian ekstrak buah okra dengan dosis 0,375 ml/100 gBB tikus, 0,75 ml/100 gBB tikus, dan 1,5 ml/100 gBB tikus tidak mempunyai efek menurunkan kadar glukosa darah tikus Wistar. Kata kunci: abelmoschus esculentus, buah okra, kadar glukosa darah, aloksan

scholarly journals Association between elevated blood glucose level and non-valvular atrial fibrillation: a report from the Guangzhou heart study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Lu Fu ◽  
Hai Deng ◽  
Wei-dong Lin ◽  
Shang-fei He ◽  
Fang-zhou Liu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Rural Areas ◽  
Elevated Blood ◽  
Sample Collection ◽  
Elevated Blood Glucose ◽  
Elevated Blood Glucose Level ◽  
Heart Study

Abstract Background To estimate the prevalence of elevated blood glucose level (EBG, including type 2 diabetes mellitus and impaired fasting glucose), and its association with non-valvular atrial fibrillation (NVAF) in Guangzhou, China. Methods The population-based follow-up Guangzhou Heart Study collected baseline data from July 2015 to August 2017 among 12,013 permanent residents aged > 35 from 4 Guangzhou districts. Two streets (Dadong and Baiyun) in the Yuexiu District, and one street (Xiaoguwei) and two towns (Xinzao and Nancun) in the Panyu District were chosen as representative of urban and rural areas, respectively. Each participant completed a comprehensive questionnaire, and underwent physical examination, blood sample collection for laboratory testing, electrocardiography, and other evaluations. Multivariable logistic regression analyses were used to estimate the independent association between hyperglycemia and NVAF prevalence. Results The prevalence of EBG in overall study population was 29.9%. Compared with residents without EBG, the odds ratio (OR) for AF among residents with EBG was significantly higher (1.94, 95% confidence interval [CI]: 1.40–2.70, P <  0.001), even after multivariate adjustment for metabolic abnormalities (OR = 1.60, 95% CI: 1.14–2.25, P = 0.007), and driven by women (OR = 1.80, 95% CI: 1.12–2.91, P = 0.016). Conclusions In Guangzhou, China, prevalence of EBG is high among residents aged > 35 years and associated with a multivariate adjusted increase in prevalence of NVAF overall and in women.

Sign in / Sign up

Export Citation Format

Share Document