scholarly journals Takotsubo cardiomyopathy induced during dobutamine stress echocardiography: an exhaustive review

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
A Kasongo ◽  
A Kone ◽  
D De Zuttere ◽  
P Meimoun ◽  
H Lardoux
Keyword(s):  
Takotsubo Cardiomyopathy ◽  
Stress Echocardiography ◽  
Dobutamine Stress Echocardiography ◽  
Dobutamine Stress ◽  
Left Ventricular ◽  
Rapid Recovery ◽  
Left Ventricular Ejection ◽  
Female Population ◽  
Coronary Syndrome ◽  
Central Registry

Abstract Funding Acknowledgements Type of funding sources: None. Introduction. Takotsubo cardiomyopathy (TTC) mimics an acute coronary syndrome and corresponds to an acute reversible stress-induced cardiomyopathy. Dobutamine Stress Echocardiography (DSE) has been widely used for more than 30 years and is considered as one of the gold standard non-invasive test to detect myocardial ischemia. DSE responsible for a TTC is a rare clinical entity. Purpose. Dobutamine induced takotsubo Cardiomyopathy (TTC-DSE) is an exceptional situation. We systematically search for TTC-DSE observations to analyse the specific characteristics of such a cohort. Methods and Results.  We conducted an extensive search in Medline, and the Cochrane Central Registry of Controlled Trials, using the key words "acute cardiomyopathy, takotsubo syndrome and DSE". File selection was based on the following criteria : (a) occurrence of TTC during DSE, (b) Mayo Clinic criteria (1) associating transient left ventricular systolic dysfunction, absence of significant coronary stenosis, ST-T abnormalities on EKG, moderate troponin elevation, and absence of pheochromocytoma or myocarditis. We identified 30 clinical observations of TTC-DSE published between 2006 and 2019, mostly from USA and Europe publications. Symptoms appear at high dobutamine dosages (30 or 40 gammas/kg/min: 24/30), rarely during recovery (4/30). These patients have the typical features of TTC : (1) strong predominance of a female population (26 women; 86.7%), aged over 50 years (24; 93.3%); (2) depression and/or anxiety (8 pts; 26.7%);  (3) ECG: ST elevation (21 pts; 70 %), ST depression (2 pts), no ST change (4 pts), and left conduction block (3 pts); (4) emergency coronary angiography without significant coronary lesion; (5) angiographic left ventricular ejection fraction (LVEF), calculated in 18/30pts : < 40% for 14/18 pts; (6) segmental LV impairment (echo or angio): apical n = 17 (77.3%); mid-ventricular n = 3 (13.6%); reverse n = 2 (9%) and unspecified (8 pts); (7) low peak of Troponin: 2.65 ± 2.04 ng/ml; (8) one death from an acute heart failure (old lady 86 years age, with intra ventricular gradient), and rapid recovery of LVEF in other patients (29 pts). Despite the heterogeinity in TTC-DSE patients and large cohort of patients in the TTC publications, TTC-DSE and TTC patients have comparable caracteristics. Conclusion. TTC-DSE is an exceptional, but severe complication of DSE. It provides a unique opportunity to observe TTC in the acute phase. These observational studies show a similar profile between TTC-DSE and TTC patients. Mortality remains low in TTC-DSE cohort, probably because of prompt interruption of the test. Rapid recovery of LV function is consistent. High level of sympathetic stimulation secondary to dobutamine infusion, and frequent anxiety associated with DSE, are probably the major determinants of TTC-DSE. However, the rarity of the TTC-DSE, compared to the widespread daily practice of DSE in echo-laboratories, remains unexplained.

scholarly journals Utility of dobutamine stress echocardiography in aortic valve regurgitation and reduced left ventricular function

2021 ◽  
Author(s):  
Chihiro Saito ◽  
Kotaro Arai ◽  
Kyomi Ashihara ◽  
Hiroshi Niinami ◽  
Nobuhisa Hagiwara
Keyword(s):  
Aortic Valve ◽  
Stress Echocardiography ◽  
Dobutamine Stress Echocardiography ◽  
Dobutamine Stress ◽  
Left Ventricular ◽  
Valve Surgery ◽  
Left Ventricular Ejection ◽  
Reverse Remodeling ◽  
Aortic Valve Surgery ◽  
Ventricular Ejection Fraction

Objective: Predictors for post-operative reverse remodeling in patients with severe aortic regurgitation (AR) and reduced left ventricular ejection fraction (LVEF) are unknown. We performed low-dose dobutamine stress echocardiography (DSE) in patients with severe AR and reduced LVEF to evaluate the relationship between contractile reserve (CR) and reverse remodeling after surgery. Methods: In 31 patients with chronic severe AR and reduced LVEF (LVEF < 50%), we performed pre-operative DSE, assessed CR and examined whether changes in preoperative DSE were associated with improvement of post-operative LVEF after aortic valve surgery. Results: The pre-operative echocardiographic findings were as follows: left ventricular (LV) end-diastolic dimension: 67 ± 10 mm, LV end-systolic dimension: 52 ± 13 mm and LVEF: 42% ± 8%. All patients underwent aortic valve surgery. Patients with pre-operative LVEF of >45% exhibited a significant increase in LVEF; however, patients with pre-operative LVEF of <45% showed no significant change. When we examined the results of DSE performed in patients with pre-operative LVEF of <45%, ΔLVEF of ≥6% (with CR) during DSE was related to an improvement in post-operative LVEF; ΔLVEF of ≥6% during DSE predicted an improvement in post-operative LVEF, with a sensitivity and specificity of 80% and 85%, respectively. Conclusions: DSE may be a helpful tool for predicting post-operative reverse remodeling in patients with severe AR and moderately reduced LVEF.

scholarly journals Dobutamine Stress Echocardiography with B-Mode Speckle Tracking in Patients after Acute Coronary Syndromes: Diagnostic and Prognostic Value

2020 ◽  
pp. 28-37
Author(s):  
S. V. Potashev ◽  
S. V. Salo ◽  
A. Y. Gavrylyshyn ◽  
S. A. Rudenko ◽  
O. M. Holtvian
Keyword(s):  
Coronary Artery ◽  
Myocardial Viability ◽  
Speckle Tracking ◽  
Stress Echocardiography ◽  
Dobutamine Stress Echocardiography ◽  
Dobutamine Stress ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Low Grade ◽  
Coronary Reserve

  Background. Speckle tracking echocardiography (STE) provides valuable data on myocardial function. STE during dobutamine stress echocardiography (DSE) allows reliable myocardial ischemia diagnosis. Aim. To evaluate STE during DSE in patients with coronary artery disease (CAD) after acute coronary syndrome (ACS) and its accuracy in ischemia diagnosis, assessment of myocardial viability and coronary reserve. Methods. We examined 58 patients (55 [94,8 %] men and 3 [5,2 %] women) men) with CAD after ACS admitted to our Institute for defining indications for coronary interventions. All the patients underwent DSE with STE for longitudinal strain quantification. Results. Mean left ventricular ejection fraction (LVEF) was 52.4±5.8%. Significant CAD according to coronary angiography (CAG) prior to DSE was proved in 38 (65.5%) patients. All the patients had a history of ACS up to 12 years before the examination (38 [65.5%] patients after percutaneous coronary intervention (PCI), including 18 [31.0%] primary PCI; 9 [15.5%] patients after coronary artery bypass grafting (CABG); 3 [5.2%] after graft PCI, 1 [1.72%] patient after aortic valve replacement (AVR) with dilated cardiomyopathy (DCM) phenotype). There were no significant complications during DSE: 5 (8.6%) cases of relatively low grade transient arrhythmia with no need for intervention. As per DSE results, we performed 35 (60.3%) revascularization interventions: 31 (58.6%) PCI’s and 4 (6.9%) CABG procedures with good outcomes. It was shown that DSE with STE sensitivity and specificity were 89.7% and 94.7% (AUC 0.92), respectively, with positive and negative predictive values of 97.2% and 81.8%, respectively, with extremely high OR 157.5, p<0.0001. Combined quantification of ΔGLS and ΔWMSI showed insignificantly lower sensitivity (86.3% [p=0.57]) and specificity (87.8% [p=0.19]) vs. integral semiquantitative ischemia markers with significantly lower overall method accuracy (AUC 0.79, p=0.047). Conclusions. DSE with STE as a visualization method is a safe and optimal method for ischemia diagnosis, as well as for myocardial viability and coronary reserve assessment in patients with CAD after ACS with the aim of risk stratification and defining indications for interventions and myocardial revascularization.

Sign in / Sign up

Export Citation Format

Share Document