P1836 Common carotid artery intima-media thickness correlates with the epicardial fat thickness in patients with ischemic stroke

Abstract The relationship between epicardial fat thickness and coronary atherosclerosis is well known, but the value of the increased epicardial fat thickness in cerebrovascular diseases is still unclear. Purpose The aim of this study was to determine the relationship between common carotid artery intima–media thickness (CCA-IMT), the resistance index (RI) in the vertebral and carotid arteries and epicardial fat thickness (EFT) in patients with ischemic stroke. Methods 98 patients with ischemic stroke (31 females and 67 males, mean age was 68.2 ± 12.1 years) were studied. All patients had arterial hypertension (AH). Most of them (96.9%) had grade 3 hypertension according to ESH/ESC Guidelines for the management of arterial hypertension, 2018. Forty-two (43.1%) patients had coronary artery disease and 35 (35.4%) - atrial fibrillation (AF). The exclusion criteria was the presence of chronic obstructive pulmonary disease or other diseases associated with pulmonary hypertension. Patients were categorized according to National Institutes of Health Stroke Scale (NIHSS) severity in mild NIHSS (≤8) - 54 (55.1%) patients, moderate NIHSS (9–15) - 23 (23.5%) patients, and severe stroke NIHSS (≥16) - 21 (21.4%) patients. Median NIHSS score was 11.2 ± 1.7. All patients underwent a transthoracic echocardiography and a carotid ultrasound examination. Results The common carotid artery intima–media thickness correlated with EFT (r =0.78, p < 0.001), the body mass index (r = 0.7, p < 0.001) and systolic blood pressure (r = 0.25, p = 0.045). The resistance index in the vertebral and carotid arteries correlated only with EFT (r = 0.7, p < 0.001 and r = 0.78, p < 0.001, respectively) and body mass index (r = 0.58, p < 0.001 and r = 0.68, p < 0.001, respectively). A multiple regression analysis in which the CCA-IMT was a dependent variable and age, body mass index, systolic blood pressure, blood cholesterol level and epicardial fat thickness were independent variables, showed that CCA-IMT was independently correlated with blood cholesterol level (β=0.714, р<0.001) and EFT (β =0.255, р=0.002) in patients with ischemic stroke. Conclusions The common carotid artery intima–media thickness and parameters of the arterial stiffness of the extracranial vessels of the head are associated with the epicardial fat thickness and blood cholesterol level in patients with ischemic stroke. The common carotid artery intima–media thickness does not depend on age, gender, body mass index, systolic and diastolic blood pressure in patients with ischemic stroke.

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Echocardiographic association of epicardial fat with carotid intima–media thickness in patients with type 2 diabetes

Diabetes and Vascular Disease Research ◽

10.1177/1479164119827602 ◽

2019 ◽

Vol 16 (4) ◽

pp. 378-384 ◽

Cited By ~ 2

Author(s):

Saeed Yafei ◽

Fathy Elsewy ◽

Eman Youssef ◽

Mohamed Ayman ◽

Mohamed Elshafei ◽

...

Keyword(s):

Type 2 Diabetes ◽

Body Mass Index ◽

Body Mass ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Epicardial Fat ◽

Epicardial Fat Thickness ◽

Media Thickness ◽

Fat Thickness

Background: Epicardial fat is recognized as active endocrine organ and as emerging risk factor for cardio-metabolic diseases. The aim of this study was to explore the relationship between epicardial fat and carotid intima–media thickness in type 2 diabetes patients. Methods: Epicardial fat thickness was measured in 76 type 2 diabetes patients without clinical atherosclerotic cardiovascular disease and 30 age- and sex-matched controls. In addition to laboratory tests, all patients underwent transthoracic echocardiography for epicardial fat thickness and ultrasonographic examination of carotid intima–media thickness. Results: Patients with diabetes had higher epicardial fat thickness and carotid intima–media thickness than those of the controls (6.23 ± 1.27 mm vs 4.6 ± 1.03 mm, p < 0.001 and 0.77 ± 0.150 mm vs 0.58 ± 0.08 mm, p < 0.001, respectively). Epicardial fat thickness was correlated significantly with age, duration of type 2 diabetes, body mass index, waist circumference, HbA1c, carotid intima–media thickness, Homeostasis Model Assessment Index for insulin resistance and lipid profile in the type 2 diabetic patients. Stepwise regression analysis showed that carotid intima–media thickness, duration of diabetes, triglyceride and body mass index were the independent predictors of epicardial fat thickness, with carotid intima–media thickness the most important predictor ( β = 3.078, t = 4.058, p < 0.001). Receiver operating characteristic curve analysis was done and cut-off high-risk epicardial fat thickness value of 6.1 mm was determined with a sensitivity and specificity of 71.4% and 72%, respectively. Conclusion: Patients with type 2 diabetes have higher carotid intima–media thickness and epicardial fat thickness. Epicardial fat thickness was found to be a strong predictor of subclinical atherosclerosis.

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Epicardial fat thickness correlates with ApoB/ApoA1 ratio, coronary calcium and carotid intima media thickness in asymptomatic subjects

International Journal of Cardiology ◽

10.1016/j.ijcard.2011.06.045 ◽

2011 ◽

Vol 151 (2) ◽

pp. 234-236 ◽

Cited By ~ 16

Author(s):

Julio Oscar Cabrera Rego ◽

Gianluca Iacobellis ◽

Julio C. Gandarilla Sarmientos ◽

Juan Valiente Mustelier ◽

Eddy W. Olivares Aquiles ◽

...

Keyword(s):

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Coronary Calcium ◽

Epicardial Fat ◽

Epicardial Fat Thickness ◽

Media Thickness ◽

Fat Thickness ◽

Asymptomatic Subjects

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Novel markers of endothelial dysfunction and inflammation in Behçet’s disease patients with ocular involvement: epicardial fat thickness, carotid intima media thickness, serum ADMA level, and neutrophil-to-lymphocyte ratio

Clinical Rheumatology ◽

10.1007/s10067-015-2907-0 ◽

2015 ◽

Vol 35 (3) ◽

pp. 701-708 ◽

Cited By ~ 20

Author(s):

Murat Yuksel ◽

Abdulkadir Yildiz ◽

Mustafa Oylumlu ◽

Fatih Mehmet Turkcu ◽

Mehmet Zihni Bilik ◽

...

Keyword(s):

Endothelial Dysfunction ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Epicardial Fat ◽

Ocular Involvement ◽

Adma Level ◽

Epicardial Fat Thickness ◽

Lymphocyte Ratio ◽

Media Thickness ◽

Fat Thickness

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The Evaluation of Epicardial Fat Thickness and Carotid Intima-Media Thickness in the Patients with Subclinical and Overt Hypothyroidism

Journal of Contemporary Medicine ◽

10.16899/jcm.577187 ◽

2019 ◽

Author(s):

Abdullah Doğan

Keyword(s):

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Epicardial Fat ◽

Overt Hypothyroidism ◽

Epicardial Fat Thickness ◽

Media Thickness ◽

Fat Thickness

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Correlation between epicardial fat thickness with intima–media thickness and ankle–brachial index in patients with metabolic syndrome

The National Medical Journal of India ◽

10.25259/nmji_182_18 ◽

2021 ◽

Vol 34 ◽

pp. 151-153

Author(s):

KARLA C. ARANA-PAZOS ◽

JORGE L. NARVAEZRIVERA ◽

ALBERTO MACEDA-SERRANO ◽

DANIEL R. BENITEZ-MALDONADO ◽

ALBERTO FRANCISCO RUBIO-GUERRA

Keyword(s):

Metabolic Syndrome ◽

Cardiovascular Risk ◽

Ankle Brachial Index ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Epicardial Fat ◽

Epicardial Fat Thickness ◽

Media Thickness ◽

Fat Thickness ◽

Relationship Of

Background An increase in epicardial fat thickness (EFT) has been associated with increased cardiovascular risk and the development of atherosclerosis. Transthoracic echo-cardiography provides a reliable measurement of EFT. We evaluated the relationship of EFT with carotid intima–media thickness (CIMT) and ankle–brachial index (ABI), in patients with metabolic syndrome. Methods We assessed 80 patients with metabolic syndrome who underwent echocardiography; EFT was measured by two cardiologists. The CIMT (B-mode colour imaging of extracranial carotid arteries using high-resolution ultrasound) was also measured by a certified ultrasonographer, and ABI was measured by the main researcher. Results We did not find any correlation between ABI with EFT (r=0.0103, p=0.93) or with CIMT (r=–0.1625, p=0.15). However, we found a significant correlation between EFT and CIMT (r=0.2718, r2=0.074, p=0.015). When we evaluated the risk for a CIMT >0.9 mm in patients with an EFT >3 mm, we found a statistically significant association (p=0.039). Interestingly, only 1 patient with an EFT <3 mm had a CIMT >0.9 mm. Conclusion We found that the EFT correlates with CIMT in patients with metabolic syndrome, which explains, at least in part, the higher risk of atherosclerosis in them. Measurement of EFT should be part of the cardiovascular risk evaluation in patients with metabolic syndrome.

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Remnant Cholesterol and Common Carotid Artery Intima-Media Thickness in Patients With Ischemic Stroke

Circulation Cardiovascular Imaging ◽

10.1161/circimaging.120.010953 ◽

2021 ◽

Author(s):

Sifan Qian ◽

Shoujiang You ◽

Yaming Sun ◽

Qiuyi Wu ◽

Xianhui Wang ◽

...

Keyword(s):

Ischemic Stroke ◽

Carotid Artery ◽

Common Carotid Artery ◽

Ldl Cholesterol ◽

Density Lipoprotein ◽

Intima Media Thickness ◽

Lipoprotein Cholesterol ◽

Media Thickness ◽

Cholesterol Levels ◽

Remnant Cholesterol

Background: Remnant cholesterol makes great contribution to residual risk of cardiovascular disease, but population-based evidence on the relationship between remnant cholesterol and atherosclerosis is rare. Common carotid artery intima-media thickness (cIMT) is an imaging marker of subclinical atherosclerosis. We aimed to explore the association between remnant cholesterol levels and cIMT in patients with ischemic stroke. Methods: One thousand four hundred ninety-six ischemic stroke patients with baseline serum lipids and carotid artery imaging data were included in this analysis. Fasting remnant cholesterol was calculated as total cholesterol minus HDL (high-density lipoprotein) cholesterol minus LDL (low-density lipoprotein) cholesterol. Abnormal cIMT was defined as mean cIMT and maximum cIMT value ≥1 mm. Logistic regression and restricted cubic spline models were used to assess the relationships between remnant cholesterol levels and abnormal cIMT. Results: The multivariable-adjusted odds ratios (95% CIs) for the highest versus lowest quartile of remnant cholesterol were 2.06 (1.46–2.91) for abnormal mean cIMT and 1.70 (1.23–2.35) for abnormal maximum cIMT. There were linear associations between remnant cholesterol levels and both abnormal mean cIMT ( P for linearity, <0.001) and abnormal maximum cIMT ( P for linearity, 0.003). Moreover, the remnant cholesterol–cIMT association remained significant in the subsample of patients with optimal LDL cholesterol levels (n=179). Conclusions: Elevated fasting remnant cholesterol levels were positively associated with mean cIMT and maximum cIMT in patients with ischemic stroke, even in patients with optimal LDL cholesterol levels. Future prospective studies are needed to verify our findings and to assess the effect of remnant cholesterol–lowering interventions in patients with ischemic stroke.

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