scholarly journals P1378 Impact of maternal diabetes on fetal left atrial function

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
F Pathan ◽  
P Lam ◽  
S Sivapathan ◽  
S Orde ◽  
K Negishi ◽  
...  
Keyword(s):  
Image Quality ◽  
Left Atrial ◽  
Fetal Heart ◽  
Maternal Diabetes ◽  
Atrial Function ◽  
Left Atrial Function ◽  
Healthy Controls ◽  
Chamber View ◽  
Risk Pregnancy ◽  
The Impact

Abstract Background/Introduction: Diabetes impacts 12- 14% of pregnancies. Evaluating the impact of maternal diabetes on the fetal heart is challenging due to variable image quality and limited time for structural changes to manifest. Left atrial reservoir strain (ER) is a sensitive marker of early left atrial dysfunction which may elucidate fetal atrial dysfunction resulting from maternal diabetes. Purpose We sought to evaluate if fetal ER can detect impairment of left atrial function in the fetal heart as a result of maternal diabetes. Methods We performed a prospective observational study evaluating patients who were referred to the high risk pregnancy service as a result of maternal diabetes (pre-existing or gestational) and healthy controls. Patients were excluded if adequate imaging of the fetal myocardium was not possible. Baseline characteristics of the mother and cardio-metabolic risk factors were recorded. The fetal echocardiogram focused on the 4 chamber view. We used the 4 chamber view with closure of the mitral valve as the zero reference point (R-R) gating. The strain curves from 6 atrial segments were averaged. Normality of the data was assessed using the Shapiro-Wilk test. The Mann-Whitney U test was used to compare ER between fetuses, whose mothers had diabetes versus those fetuses whose mothers were healthy controls. Results A total of 120 fetal scans were performed. 5 were excluded due to poor image quality, which prevented strain analysis. 115 fetal scans were analysed (87 with maternal diabetes and 27 healthy controls). The diabetic subjects and controls did not defer significantly in age Mean ± SD (31± 5 vs 30± 5, p= 0.81). The mothers with diabetes had a higher body mass index than controls (Median [IQR]) (30.5 kg/m2 [25.1, 35.3] vs 24.6 kg/m2 [22.1, 28.6] p < 0.001). The presence of maternal diabetes resulted in lower fetal ER (28.5% [22.1, 36.2] vs 33.4% [26.6, 41.6] P = 0.01). Figure 1 illustrates the Box-Whisker plot comparing Fetal ER between fetuses exposed to maternal diabetes and fetuses where mothers were healthy controls. Conclusion The presence of maternal diabetes results in impaired fetal left atrial function as measured by fetal left atrial strain (ER). Abstract P1378 Figure 1

The Impact of Atrial Fibrillation Ablation on Left Atrial Function: Association with Baseline Left Atrial Function

2011 ◽  
Vol 35 (3) ◽  
pp. 327-334 ◽  
Author(s):  
MASAHARU MASUDA ◽  
KOICHI INOUE ◽  
KATSUOMI IWAKURA ◽  
ATSUNORI OKAMURA ◽  
YASUSHI KOYAMA ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrial ◽  
Atrial Function ◽  
Left Atrial Function ◽  
Atrial Fibrillation Ablation ◽  
The Impact

scholarly journals The impact of atrial fibrillation paroxysms on left atrial function measured by strain imaging

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P5605-P5605
Author(s):  
K. G. Adamyan ◽  
L. G. Tunyan ◽  
A. L. Chilingaryan ◽  
S. V. Grigoryan
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrial ◽  
Strain Imaging ◽  
Atrial Function ◽  
Left Atrial Function ◽  
The Impact

The Impact of Mitral Stenosis on Left Atrial Function Assessed by Two-Dimensional Speckle Tracking Echocardiography

2012 ◽  
Vol 29 (9) ◽  
pp. 1064-1070 ◽  
Author(s):  
Sait Demirkol ◽  
Ugur Kucuk ◽  
Oben Baysan ◽  
Sevket Balta ◽  
Turgay Celik ◽  
...  
Keyword(s):  
Mitral Stenosis ◽  
Left Atrial ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Atrial Function ◽  
Left Atrial Function ◽  
Two Dimensional ◽  
The Impact

Evaluation of Left Atrial Function by Real-time 3-D Echocardiography in Patients with Systemic Lupus Erythematosus

2014 ◽  
Vol 42 (2) ◽  
pp. 196-201 ◽  
Author(s):  
Kulin Li ◽  
Ruxing Wang ◽  
Min Dai ◽  
Juan Lu ◽  
Yaohong Zou ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Real Time ◽  
Lupus Erythematosus ◽  
Left Atrial ◽  
Left Atrial Volume ◽  
Atrial Function ◽  
Left Atrial Function ◽  
Healthy Controls ◽  
Systemic Lupus ◽  
Atrial Volume

Objective.Left atrial function plays a key role in maintaining an optimal cardiac output. Left ventricular diastolic dysfunction has been reported in systemic lupus erythematosus (SLE), but its effect on left atrial function has been largely overlooked. Our aim was to assess left atrial performance using real-time 3-D echocardiography (RT3DE) technology in patients with SLE.Methods.Our study included 102 patients with SLE without any cardiac symptoms, and 32 healthy controls. According to the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), all subjects were classified into 3 groups: healthy controls, patients with an SDI = 0, and patients with an SDI ≥ 1.Results.Left atrial volume indexed to body surface area was dilated in subjects with SLE, whereas the left atrial passive emptying fraction (EF) was lower. Left atrial active EF was significantly higher in the SDI = 0 group than in controls (46.4 ± 9.1% vs 30.0 ± 10.3%, p < 0.05); however, it was significantly lower in the SDI ≥ 1 group than in the SDI = 0 group (41.2 ± 9.8% vs 46.4 ± 9.1%, p < 0.05). By multivariate linear analysis, the SDI was independently and positively associated with left atrial volume index and inversely associated with left atrial total function.Conclusion.Our study demonstrated that left atrial mechanical function and volume are impaired in SLE, particularly in patients with an SDI ≥ 1 and disease activity. RT3DE may have better diagnostic value than traditional echo indexes in detecting subclinical cardiac dysfunction in patients with SLE.

scholarly journals Assessment of left atrial function in dilated cardiomyopathy patients using speckle-tracking echocardiography

2020 ◽  
Vol 2 (1) ◽  
pp. 27-32
Author(s):  
Taher Said Abdelkarim ◽  
Mohamed Abd El-Hafez Fouly ◽  
Ashraf Zahrah
Keyword(s):  
Ejection Fraction ◽  
Dilated Cardiomyopathy ◽  
Left Atrial ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Atrial Function ◽  
Left Atrial Function ◽  
Strain Rates ◽  
Healthy Controls ◽  
Maximum Volume

Background: The available methods to assess left atrial function (LAF) have some limitations as angle dependence and opposite distortion. The objective of the current study was to evaluate LAF in dilated cardiomyopathy (DCM) of ischemic (IDCM) and non-ischemic etiologies (NIDCM) using speckle tracking echocardiography (STE). Methods: 52 patients with systolic heart failure were included in our study; 27 with IDCM and 25 with NIDCM along with 15 healthy controls. All patients underwent conventional echocardiography, tissue doppler imaging, and speckle tracking echocardiography. The later modality was used to compare left atrial function in IDCM and NIDCM groups. Results: We found the left atrial maximum volume and the left atrial total emptying volume to be higher in patients with dilated cardiomyopathy compared to healthy patients (52.19 ± 6.01 vs.  21.87 ± 1.69 cm3/m2; p <0.001 and 28.67 ± 4.34 vs. 15.67 ± 2.02 cm3/m2, respectively). Conversely, left atrial emptying index and left atrial active ejection fraction were lower in patients with DCM compared to healthy controls (9.60 ± 2.29 vs. 8.27 ± 3.01 cm3/m2; p< 0.001 and 23 ± 2.56 vs. 37.47 ± 3.54 %; p<0.001, respectively). When comparing the IDCM group with NIDCM patients, we found no significant difference in left atrial maximum volume and left atrial active emptying volume. However, the NIDCM patients had significantly lower left atrial total emptying volume, and left atrial active ejection fraction (8.93 ± 1.86 vs. 9.60 ± 2.29 cm3/m2 and 23 ± 2.56 vs. 31.19 ± 1.66 %; p<0.001). on comparing strain function, DCM patients had lower systolic (28.22 ± 3.84 vs. 60.87 ± 3.07 %, p<0.001), and left atrial systolic strain rate (-2.66 ± 0.45 vs. -3.81 ± 0.35; p = 0.003) compared to healthy controls. All strains and strain rates were significantly lower in NIDCM patients compared to IDCM patients.   Conclusion: STE is a promising method for evaluating LAF in DCM patients. Patients with DCM had significantly lower left atrial systolic and late diastolic strains and strain rates compared to healthy patients. Moreover, NIDCM could be differentiated from IDCM by having more impairment in the LA dynamic reservoir and booster pump function.

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