scholarly journals 5117Lacking treatment effect of ICD in heart failure patients lacking ischemic heart disease and age? A meta-analysis and meta-regression focusing on moderators and the DANISH trial

2017 ◽  
Vol 38 (suppl_1) ◽  
Author(s):  
M.M. Thomsen ◽  
C. Lewinter
Keyword(s):  
Heart Failure ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Treatment Effect ◽  
Meta Analysis ◽  
Ischemic Heart ◽  
Heart Failure Patients ◽  
Meta Regression

scholarly journals Mobile Phone Technologies in the Management of Ischemic Heart Disease, Heart Failure, and Hypertension: Systematic Review and Meta-Analysis

10.2196/16695 ◽  
2020 ◽  
Vol 8 (7) ◽  
pp. e16695 ◽  
Author(s):  
Praveen Indraratna ◽  
Daniel Tardo ◽  
Jennifer Yu ◽  
Kim Delbaere ◽  
Matthew Brodie ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Mobile Phone ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Ischemic Heart ◽  
Valuable Adjunct

Background Cardiovascular disease (CVD) remains the leading cause of death worldwide. Mobile phones have become ubiquitous in most developed societies. Smartphone apps, telemonitoring, and clinician-driven SMS allow for novel opportunities and methods in managing chronic CVD, such as ischemic heart disease, heart failure, and hypertension, and in the conduct and support of cardiac rehabilitation. Objective A systematic review was conducted using seven electronic databases, identifying all relevant randomized control trials (RCTs) featuring a mobile phone intervention (MPI) used in the management of chronic CVD. Outcomes assessed included mortality, hospitalizations, blood pressure (BP), and BMI. Methods Electronic data searches were performed using seven databases from January 2000 to June 2019. Relevant articles were reviewed and analyzed. Meta-analysis was performed using standard techniques. The odds ratio (OR) was used as a summary statistic for dichotomous variables. A random effect model was used. Results A total of 26 RCTs including 6713 patients were identified and are described in this review, and 12 RCTs were included in the meta-analysis. In patients with heart failure, MPIs were associated with a significantly lower rate of hospitalizations (244/792, 30.8% vs 287/803, 35.7%; n=1595; OR 0.77, 95% CI 0.62 to 0.97; P=.03; I2=0%). In patients with hypertension, patients exposed to MPIs had a significantly lower systolic BP (mean difference 4.3 mm Hg; 95% CI −7.8 to −0.78 mm Hg; n=2023; P=.02). Conclusions The available data suggest that MPIs may have a role as a valuable adjunct in the management of chronic CVD.

scholarly journals Mobile Phone Technologies in the Management of Ischemic Heart Disease, Heart Failure, and Hypertension: Systematic Review and Meta-Analysis (Preprint)

2019 ◽  
Author(s):  
Praveen Indraratna ◽  
Daniel Tardo ◽  
Jennifer Yu ◽  
Kim Delbaere ◽  
Matthew Brodie ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Mobile Phone ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Ischemic Heart ◽  
Valuable Adjunct

BACKGROUND Cardiovascular disease (CVD) remains the leading cause of death worldwide. Mobile phones have become ubiquitous in most developed societies. Smartphone apps, telemonitoring, and clinician-driven SMS allow for novel opportunities and methods in managing chronic CVD, such as ischemic heart disease, heart failure, and hypertension, and in the conduct and support of cardiac rehabilitation. OBJECTIVE A systematic review was conducted using seven electronic databases, identifying all relevant randomized control trials (RCTs) featuring a mobile phone intervention (MPI) used in the management of chronic CVD. Outcomes assessed included mortality, hospitalizations, blood pressure (BP), and BMI. METHODS Electronic data searches were performed using seven databases from January 2000 to June 2019. Relevant articles were reviewed and analyzed. Meta-analysis was performed using standard techniques. The odds ratio (OR) was used as a summary statistic for dichotomous variables. A random effect model was used. RESULTS A total of 26 RCTs including 6713 patients were identified and are described in this review, and 12 RCTs were included in the meta-analysis. In patients with heart failure, MPIs were associated with a significantly lower rate of hospitalizations (244/792, 30.8% vs 287/803, 35.7%; n=1595; OR 0.77, 95% CI 0.62 to 0.97; <i>P</i>=.03; I<sup>2</sup>=0%). In patients with hypertension, patients exposed to MPIs had a significantly lower systolic BP (mean difference 4.3 mm Hg; 95% CI −7.8 to −0.78 mm Hg; n=2023; <i>P</i>=.02). CONCLUSIONS The available data suggest that MPIs may have a role as a valuable adjunct in the management of chronic CVD.

scholarly journals Difference in Angiotensinogen Haplotype Frequencies Between Chronic Heart Failure and Advanced Atherosclerosis Patients – New Prognostic Factor?

2011 ◽  
pp. 55-64 ◽  
Author(s):  
M. PÁVKOVÁ GOLDBERGOVÁ ◽  
L. ŠPINAROVÁ ◽  
J. ŠPINAR ◽  
J. PAŘENICA ◽  
L. ŠIŠKOVÁ ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Disease ◽  
Chronic Heart Failure ◽  
Ischemic Heart Disease ◽  
Genetic Variants ◽  
Association Studies ◽  
Ischemic Heart ◽  
Heart Failure Patients ◽  
Triple Vessel Disease

Numerous association studies have been involved in studying the angiotensinogen (AGT) variants, AGT plasma levels and relations to cardiovascular diseases, such as hypertension, myocardial infarction, coronary heart disease. To investigate a role of AGT G(-6)A and M235T genetic variants for chronic heart failure (CHF) and advanced atherosclerosis (AA), a total of 240 patients with CHF and 200 patients with AA of the Czech origin were evaluated for the study. The study shows the role of polymorphism AGT G(-6)A in genetic background among advanced atherosclerosis patients and chronic heart failure patients (Pg=0.001). This difference was also observed in comparison of AA patients with subgroup of CHF with dilated cardiomyopathy (Pg=0.02; Pa=0.009), and ischemic heart disease (Pg=0.007). The greatest difference between triple-vessel disease and chronic heart failure groups was observed in frequency of GT haplotype (P<0.001) and GGMT associated genotype (P<0.001). Retrospectively, we found the same trend when the subgroups of CHF were compared to AA group (AA vs. IHD with CHF P<0.001; AA vs. DCM P<0.001). These results suggest AGT genetic variants as a risk factor for chronic heart failure compared to advanced atherosclerosis disease without heart failure, with a strong difference between IHD patients and chronic heart failure patients with ischemic heart disease, especially in haplotypes and associated genotypes.

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