P4935Coronary artery disease underlies most sports-related sudden cardiac arrest in the general population

Abstract Background Knowledge about causes of sports-related sudden cardiac arrest (SrSCA) may influence national strategies to prevent such events. Purpose We established a prospective registry on SrSCA to estimate the incidence and in particular describe the etiologies of SrSCA in the general population in Germany. Methods The registration of SrSCA based upon 4 pillars: a) a web-based platform to record SrSCA cases in competitive and recreational athletes, b) media-monitoring and c) a cooperation with the German Resuscitation Registry as well as d) 15 institutes of forensic medicine. Results After an observation period of 6 years, a total of 349 cases was recorded (mean age 48.0±12.7 years) of which 109 subjects survived. Most of the cases occurred during non-elite competitive or recreational sports. Bystander cardiopulmonary resuscitation (CPR) was initiated in 262 cases (75%), however rhythm analysis and defibrillation (if indicated) was mainly performed by medical service. In subjects ≤35 years, premature coronary artery disease (CAD) and sudden arrhythmic death syndrome (SADS) prevailed, followed by myocarditis. In athletes ≥35 years, CAD predominated. Conclusion The prevalence of cardiac pathologies in young athletes seems to vary across different countries. CAD represents the most common cause of SrSCA in the general population of Germany, highlighting the need for a targeted cardiovascular risk evaluation including young athletes. Public education on basic life support including the appropriate use of an automated external defibrillator (AED) may further decrease the burden of sudden cardiac death. Acknowledgement/Funding Funding from the German Heart Foundation

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Coronary artery disease underlies most sports-related sudden cardiac arrest in the general population

Archives of Cardiovascular Diseases Supplements ◽

10.1016/j.acvdsp.2017.11.187 ◽

2018 ◽

Vol 10 (1) ◽

pp. 123-124

Author(s):

A. Sharifzadehgan ◽

N. Karam ◽

W. Bougouin ◽

V. Waldmann ◽

F. Dumas ◽

...

Keyword(s):

Coronary Artery Disease ◽

Cardiac Arrest ◽

Coronary Artery ◽

General Population ◽

Sudden Cardiac Arrest ◽

Artery Disease

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Contacts to the healthcare system prior to out-of-hospital cardiac arrests

European Heart Journal ◽

10.1093/ehjci/ehaa946.0766 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

N Zylyftari ◽

S.G Moller ◽

M Wissenberg ◽

F Folke ◽

C.A Barcella ◽

...

Keyword(s):

Cardiac Arrest ◽

General Population ◽

Healthcare System ◽

Early Identification ◽

Sudden Cardiac Arrest ◽

Funding Source ◽

Horizon 2020 ◽

One Year ◽

Public Grant ◽

Hospital Cardiac Arrest

Abstract Background Patients who suffer a sudden out-of-hospital cardiac arrest (OHCA) may be preceded by warning symptoms and healthcare system contact. Though, is currently difficult early identification of sudden cardiac arrest patients. Purpose We aimed to examine contacts with the healthcare system up to two weeks and one year before OHCA. Methods OHCA patients were identified from the Danish Cardiac Arrest Registry (2001–2014). The pattern of healthcare contacts (with either general practitioner (GP) or hospital) within the year prior to OHCA of OHCA patients was compared with that of 9 sex- and age-matched controls from the background general population. Additionally, we evaluated characteristics of OHCA patients according to the type of healthcare contact (GP/hospital/both/no-contact) and the including characteristics of contacts, within two weeks prior their OHCA event. Results Out of 28,955 OHCA patients (median age of 72 (62–81) years and with 67% male) of presumed cardiac cause, 16,735 (57.8%) contacted the healthcare system (GP and hospital) within two weeks prior to OHCA. From one year before OHCA, the weekly percentages of contacts to GP were relatively constant (26%) until within 2 weeks prior to OHCA where they markedly increased (54%). In comparison, 14% of the general population contacted the GP during the same period (Figure). The weekly percentages of contacts with hospitals gradually increased in OHCA patients from 3.5% to 6.5% within 6 months, peaking at the second week (6.8%), prior to OHCA. In comparison, only 2% of the general population had a hospital contact in that period (Figure). Within 2 weeks of OHCA, patients contacted GP mainly by telephone (71.6%). Hospital diagnoses were heterogenous, where ischemic heart disease (8%) and heart failure (4.5%) were the most frequent. Conclusions There is an increase in healthcare contacts prior to “sudden” OHCA and overall, 54% of OHCA-patients had contacted GP within 2 weeks before the event. This could have implications for developing future strategies for early identification of patients prior to their cardiac arrest. Figure 1. The weekly percentages of contacts to GP (red) and hospital (blue) within one year before OHCA comparing the OHCA cases to the age- and sex-matched control population (N cases = 28,955; N controls = 260,595). Funding Acknowledgement Type of funding source: Public grant(s) – EU funding. Main funding source(s): European Union's Horizon 2020

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Recurrent Sudden Cardiac Arrest in the General Population

SSRN Electronic Journal ◽

10.2139/ssrn.3916663 ◽

2021 ◽

Author(s):

Elizabeth Paver Held ◽

Kyndaron Reinier ◽

Harpriya Chugh ◽

Audrey Uy-Evanado ◽

Jonathan Jui ◽

...

Keyword(s):

Cardiac Arrest ◽

General Population ◽

Sudden Cardiac Arrest

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P2514Cocaine-related sudden cardiac arrest in the general population

European Heart Journal ◽

10.1093/eurheartj/ehy565.p2514 ◽

2018 ◽

Vol 39 (suppl_1) ◽

Author(s):

A Sharifzadehgan ◽

W Bougouin ◽

V Waldmann ◽

N Karam ◽

B Gaye ◽

...

Keyword(s):

Cardiac Arrest ◽

General Population ◽

Sudden Cardiac Arrest

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Possible GoLytely-Associated Cardiac Arrest: A Case Report and Literature Review

Journal of Pharmacy Practice ◽

10.1177/0897190019825965 ◽

2019 ◽

Vol 33 (3) ◽

pp. 364-367 ◽

Cited By ~ 2

Author(s):

Yoonsun Mo ◽

Shiv Gandhi ◽

Jose Orsini

Keyword(s):

Cardiac Arrest ◽

Abdominal Pain ◽

Sudden Cardiac Arrest ◽

Lower Abdominal Pain ◽

The Past ◽

Life Threatening ◽

History Of ◽

Artery Disease ◽

Possible Cause

Purpose: To report a case of sudden cardiac arrest possibly associated with the administration of GoLytely® (polyethylene glycol 3350 and electrolytes). Summary: A 60-year-old male with a history of hypertension, hyperlipidemia, type 2 diabetes, and coronary artery disease presented to the emergency department with complaints of constipation and lower abdominal pain over the past week, and the inability to urinate over the past day. The patient had received GoLytely as treatment to alleviate symptoms of constipation and abdominal pain. However, several hours after administration of the bowel prep solution, the patient suffered an episode of cardiac arrest. After ruling out other possible etiologies, GoLytely was suspected as a possible cause of cardiac arrest. The patient had suffered an anoxic brain injury and remained intubated and unconscious until he eventually expired, 20 days after the event. Conclusion: Although GoLytely appears to be a safe agent with fewer side effects, clinicians need to be mindful of potential life-threatening adverse events following GoLytely administration and monitor patients closely during and after administration.

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Familial clustering of cardiac conditions in patients with anomalous aortic origin of a coronary artery and myocardial bridges

Cardiology in the Young ◽

10.1017/s1047951118000835 ◽

2018 ◽

Vol 28 (9) ◽

pp. 1099-1105 ◽

Cited By ~ 1

Author(s):

Hitesh Agrawal ◽

Carlos M. Mery ◽

S. Kristen Sexson Tejtel ◽

Charles D. Fraser ◽

E. Dean McKenzie ◽

...

Keyword(s):

Coronary Artery Disease ◽

Cardiac Arrest ◽

Coronary Artery ◽

Family History ◽

Positive Family History ◽

Sudden Cardiac Arrest ◽

Coronary Anomalies ◽

Myocardial Bridge ◽

Familial Clustering ◽

Artery Disease

AbstractBackgroundAnomalous aortic origin of a coronary artery is the second leading cause of sudden cardiac arrest/death in young athletes in the United States of America. Limited data are available regarding family history in this patient population.MethodsPatients were evaluated prospectively from 12/2012 to 02/2017 in the Coronary Anomalies Program at Texas Children’s Hospital. Relevant family history included the presence of CHD, sudden cardiac arrest/death, arrhythmia/pacemaker use, cardiomyopathy, and atherosclerotic coronary artery disease before the age of 50 years. The presence of one or more of these in 1st- or 2nd-degree relatives was considered significant.ResultsOf 168 unrelated probands (171 patients total) included, 36 (21%) had significant family history involving 19 (53%) 1st-degree and 17 (47%) 2nd-degree relatives. Positive family history led to cardiology referral in nine (5%) patients and the presence of abnormal tests/symptoms in the remaining patients. Coronary anomalies in probands with positive family history were anomalous right (27), anomalous left (five), single right coronary artery (two), myocardial bridge (one), and anomalous circumflex coronary artery (one). Conditions present in their family members included sudden cardiac arrest/death (15, 42%), atherosclerotic coronary artery disease (14, 39%), cardiomyopathy (12, 33%), CHD (11, 31%), coronary anomalies (3, 8%), myocardial bridge (1, 3%), long-QT syndrome (2, 6%), and Wolff–Parkinson–White (1, 3%).ConclusionIn patients with anomalous aortic origin of a coronary artery and/or myocardial bridges, there appears to be familial clustering of cardiac diseases in approximately 20% of patients, half of these with early occurrence of sudden cardiac arrest/death in the family.

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