Q- AND C-BAND CHROMOSOME MARKERS IN INBRED STRAINS OF MUS MUSCULUS

ABSTRACT Differences in the number of chromosomes with secondary constrictions and in the size of the C-band region on certain chromosomes have been observed among the following inbred strains of Mus musculus: C57BL/10J, C57BR/cdJ, DBA/1J, CBA/J, BALB/cJ, and AKR. These differences are useful as indicators of the location of rRNA genes and as normal chromosome markers. The size of each C-band region appears to remain constant over many generations. Only one probable change in the size of a C-band region was found.

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CHROMOSOME MARKERS IN MUS MUSCULUS: STRAIN DIFFERENCES IN C-BANDING

Genetics ◽

10.1093/genetics/75.4.663 ◽

1973 ◽

Vol 75 (4) ◽

pp. 663-670

Author(s):

V G Dev ◽

D A Miller ◽

O J Miller

Keyword(s):

Mus Musculus ◽

Strain Differences ◽

Inbred Strains ◽

F1 Hybrids ◽

Centromeric Heterochromatin ◽

Mitotic Chromosomes ◽

Homologous Chromosomes ◽

Chromosome Markers ◽

C Banding ◽

Inbred Strains Of Mice

ABSTRACT The mitotic chromosomes of several inbred strains of mice and a series of F1 hybrids have been analyzed by quinacrine staining and further characterized by the centromeric heterochromatin banding (C-banding). Inbred strains had the same amount of C-banding material on homologous chromosomes but showed variation in the amount on different chromosomes. F1 hybrids showed characteristics of each parent and it appears that the amount of C-banding on each chromosome is a simple inherited polymorphism. In this study 12 different chromosomes could be distinguished by their C-banding, and these can be used as normal chromosome markers.

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Insights into mammalian biology from the wild house mouse Mus musculus

eLife ◽

10.7554/elife.05959 ◽

2015 ◽

Vol 4 ◽

Cited By ~ 45

Author(s):

Megan Phifer-Rixey ◽

Michael W Nachman

Keyword(s):

House Mouse ◽

Mus Musculus ◽

Genetic Model ◽

Inbred Strains ◽

Mendelian Inheritance ◽

Model Organisms ◽

House Mice ◽

Small Subset ◽

Wild Mice ◽

Wide Range

The house mouse, Mus musculus, was established in the early 1900s as one of the first genetic model organisms owing to its short generation time, comparatively large litters, ease of husbandry, and visible phenotypic variants. For these reasons and because they are mammals, house mice are well suited to serve as models for human phenotypes and disease. House mice in the wild consist of at least three distinct subspecies and harbor extensive genetic and phenotypic variation both within and between these subspecies. Wild mice have been used to study a wide range of biological processes, including immunity, cancer, male sterility, adaptive evolution, and non-Mendelian inheritance. Despite the extensive variation that exists among wild mice, classical laboratory strains are derived from a limited set of founders and thus contain only a small subset of this variation. Continued efforts to study wild house mice and to create new inbred strains from wild populations have the potential to strengthen house mice as a model system.

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Serum prealbumin in inbred strains of Mus musculus

Biochemical Genetics ◽

10.1007/bf00485767 ◽

1974 ◽

Vol 11 (2) ◽

pp. 97-102 ◽

Cited By ~ 1

Author(s):

Larry Claxton ◽

H. V. Malling ◽

H. E. Walburg

Keyword(s):

Mus Musculus ◽

Inbred Strains

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Electrophoretic Variation of α-Amylase in Two Inbred Strains of Mus musculus

Journal of Heredity ◽

10.1093/oxfordjournals.jhered.a108374 ◽

1973 ◽

Vol 64 (3) ◽

pp. 155-157 ◽

Cited By ~ 27

Author(s):

RICHARD D. KAPLAN ◽

VERNE CHAPMAN ◽

FRANK H. RUDDLE

Keyword(s):

Mus Musculus ◽

Inbred Strains ◽

Electrophoretic Variation

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A correlation between hexobarbitone and pentobarbitone sleeping times in fifteen different inbred strains of mice (Mus musculus)

General Pharmacology The Vascular System ◽

10.1016/0306-3623(78)90018-6 ◽

1978 ◽

Vol 9 (3) ◽

pp. 167-170 ◽

Cited By ~ 8

Author(s):

Ian E. Lush ◽

David Lovell

Keyword(s):

Mus Musculus ◽

Inbred Strains ◽

Inbred Strains Of Mice

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Evidence of the occurrence of structural chromosome changes at the initial diploid diversification of the autopolyploid Turnera sidoides L. (Passifloraceae) complex

Genome ◽

10.1139/gen-2015-0096 ◽

2016 ◽

Vol 59 (2) ◽

pp. 127-136

Author(s):

Juan M. Roggero Luque ◽

E.M. Sara Moreno ◽

I. Evelin Kovalsky ◽

J. Guillermo Seijo ◽

Viviana G. Solís Neffa

Keyword(s):

5S Rdna ◽

Chromosome Analysis ◽

Dapi Staining ◽

Chromosome Markers ◽

Rdna Loci ◽

Structural Chromosome ◽

Turnera Sidoides ◽

Perennial Herbs ◽

Diploid Level ◽

Secondary Constrictions

Turnera sidoides is an autopolyploid complex of obligate outcrossing perennial herbs. It includes five subspecies and five morphotypes in which diploid to octoploid cytotypes were found. Based on phenetic analyses of the complex and karyotype data of polyploid cytotypes, it has been hypothesized that morphological and chromosome differentiation of T. sidoides occurred at the diploid level. To test this hypothesis, we present the first detailed chromosome analysis of diploid populations of three subspecies and four morphotypes. CMA+/DAPI− bands were restricted to secondary constrictions (except in the andino morphotype) and varied in number and position among taxa. By contrast, DAPI staining was uniform in all the materials investigated. The number and position of 45S rDNA loci were coincident with the CMA+/DAPI− bands associated with secondary constrictions. Only one pair of 5S rDNA loci was detected in all the taxa (except in subsp. holosericea), but its position was variable. The identified chromosome markers varied among the three subspecies analyzed, but they were more conserved among the morphotypes of subsp. pinnatifida. Cluster analysis of these chromosome markers supports the current taxonomic arrangement of diploids and demonstrates that structural chromosome changes would have led or accompanied the initial differentiation of T. sidoides at the diploid level.

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Chromosome markers in 12 inbred strains of the Norway rat, Rattus norvegicus

Cytogenetic and Genome Research ◽

10.1159/000131333 ◽

1979 ◽

Vol 23 (4) ◽

pp. 231-240 ◽

Cited By ~ 10

Author(s):

M. Sasaki ◽

Y. Kodama ◽

I. Hayata ◽

M.C. Yoshida

Keyword(s):

Inbred Strains ◽

Norway Rat ◽

Chromosome Markers

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GENETICS OF ALDEHYDE DEHYDROGENASE ISOZYMES IN THE MOUSE: EVIDENCE FOR MULTIPLE LOCI AND LOCALIZATION OF Ahd-2 ON CHROMOSOME 19

Genetics ◽

10.1093/genetics/97.2.327 ◽

1981 ◽

Vol 97 (2) ◽

pp. 327-336

Author(s):

Glenn P Timms ◽

Roger S Holmes

Keyword(s):

Aldehyde Dehydrogenase ◽

Mus Musculus ◽

Microsomal Fraction ◽

Inbred Strains ◽

Single Locus ◽

Linkage Data ◽

Chromosome 4 ◽

Chromosome 19 ◽

Multiple Loci ◽

Liver Microsomal Fraction

ABSTRACT Electrophoretic and activity variation of the cytoplasmic isozyme of aldehyde dehydrogenase (designated AHD-B4) was observed among inbred strains and Harwell linkage-testing stocks of Mus musculus. The phenotypes are inherited in a normal Mendelian fashion, with two alleles showing co-dominant expression at a single locus (Ahd-2). The locus was shown to segregate independently of Ahd-1 (encoding the mitochondrial AHD-A2 isozymes on chromosome 4; Holmes 1978). Linkage data of Ahd-2 with ep (pale ears), ru (ruby eyes) and bm (brachymorphic) suggest that it is localized near the centromeric end of chromosome 19. Electrophoretic evidence for a third AHD isozyme (designated AHD-Cy), which is predominantly localized in the liver microsomal fraction, is also presented.

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